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精神疾患患者の精神的予後改善に向けた生活習慣の影響解明と新規介入法開発

Research Project

Project/Area Number 22K17844
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionHokkaido University

Principal Investigator

大久保 亮  北海道大学, 病院 精神科, 医員 (00803470)

Project Period (FY) 2022-04-01 – 2026-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2024: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生活習慣 / 社会認知機能 / 心理的苦痛 / 腸内細菌 / 新型コロナウイルス / 運動習慣 / 脳機能 / 精神症状 / 認知機能
Outline of Research at the Start

食・栄養・喫煙・飲酒・身体活動・運動習慣・居住環境などの生活習慣が脳機能、精神症状に影響を及ぼすことが近年盛んに研究されているが、精神疾患患者において、生活習慣の実態や精神的予後(不安症状、抑うつ症状、精神病症状、認知機能障害など)との関連を調べた研究はほとんどない。
本研究の目的は、1)生活習慣に関する実態と課題の同定、2)生活習慣が精神的予後に与える影響の検証である。そのために、精神疾患患者を対象とした疾患コホート研究に加えて、一般住民調査資料の分析を行う。上記を明らかにして精神疾患患者の予後を改善する新規介入法を開発することを目指す。

Outline of Annual Research Achievements

本研究の目的は、1)精神疾患患者の生活習慣に関する実態と課題の同定、2)生活習慣が精神的予後に与える影響の検証である。

2022年度と同様、2023年度は、国民生活基礎調査などの統計法に基づく調査試料や、日本人の一般住民3万人のインターネット縦断調査であるJACSIS研究など、一般住民調査資料 を用いた分析研究を主に進めた。それに加えて、社会認知機能が、神経認知機能と社会機能を媒介することをうつ病患者、統合失調症患者で示すとともに、日本の臨床現場で利用可能な社会認知機能検査について示す論文を出版した。上記論文化に、図書などの消耗品を要した。また精神疾患患者のコホート研究において、生活習慣と精神的予後の関連を見る目的で、統合失調症患者約90名と健常者50名の食習慣、腸内細菌組成、神経・社会認知機能、メンタルヘルス指標の測定を完了し、解析を現在行っている。測定・解析のために、研究代表者本人、研究協力者への旅費の支出を要した。

今後も国民生活基礎調査などの統計法に基づく調査試料や、日本人の一般住民3万人のインターネット縦断調査であるJACSIS研究など、一般住民調査資料を用いた分析研究を進めると同時に、各種コホート研究など、利用可能なデータを用いて解析を進める。また、2022年度に集積した統合失調症患者約90名と健常者50名の腸内細菌組成のデータについて、解析・論文化を進めていく。特に統合失調症患者の腸内細菌組成と、神経・社会認知機能検査の関連については世界で初めての検討となる。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

研究代表者の所属機関異動があり、研究体制構築に時間を要した。

Strategy for Future Research Activity

今後も国民生活基礎調査などの統計法に基づく調査試料や、日本人の一般住民3万人のインターネット縦断調査であるJACSIS研究など、一般住民調査資料を用いた分析研究を進めると同時に、各種コホート研究など、利用可能なデータを用いて解析を進める。
また、2022年度に集積した統合失調症患者約90名と健常者50名の腸内細菌組成のデータについて、解析・論文化を進めていく。特に統合失調症患者の腸内細菌組成と、神経・社会認知機能検査の関連については世界で初めての検討となる。

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (26 results)

All 2024 2023 2022

All Journal Article (25 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 24 results,  Open Access: 7 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The association of positive emotions with absenteeism and presenteeism in Japanese workers2024

    • Author(s)
      Chen Chong、Okubo Ryo、Hagiwara Kosuke、Mizumoto Tomohiro、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 344 Pages: 319-324

    • DOI

      10.1016/j.jad.2023.10.091

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determining the optimal cutoff point for the Japanese Mother-to-Infant Bonding Scale: A data-driven approach2024

    • Author(s)
      Chen Chong、Mochizuki Yasuhiro、Asai Yoshiyuki、Okawa Sumiyo、Okubo Ryo、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 91 Pages: 103874-103874

    • DOI

      10.1016/j.ajp.2023.103874

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for persistent versus episodic mother-to-infant bonding difficulties in postpartum women in a nationwide Japanese longitudinal study2024

    • Author(s)
      Chen Chong、Okawa Sumiyo、Okubo Ryo、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 349 Pages: 370-376

    • DOI

      10.1016/j.jad.2024.01.001

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mother-to-infant bonding difficulties are associated with future maternal depression and child-maltreatment behaviors: A Japanese nationwide longitudinal study2024

    • Author(s)
      Chen Chong、Okawa Sumiyo、Okubo Ryo、Hagiwara Kosuke、Mizumoto Tomohiro、Higuchi Naoko、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Psychiatry Research

      Volume: 334 Pages: 115814-115814

    • DOI

      10.1016/j.psychres.2024.115814

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] The evaluation study for social cognition measures in Japan: Psychometric properties, relationships with social function, and recommendations2024

    • Author(s)
      Akiyama Hisashi、Okubo Ryo、Toyomaki Atsuhito、Miyazaki Akane、Hattori Sachiko、Nohara Mariko、Sasaki Yohei、Kubota Ryotaro、Okano Hiroki、Takahashi Kanami、Hasegawa Yumi、Wada Izumi、Uchino Takashi、Takeda Kazuyoshi、Ikezawa Satoru、Nemoto Takahiro、Ito Yoichi M.、Hashimoto Naoki
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 95 Pages: 104003-104003

    • DOI

      10.1016/j.ajp.2024.104003

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders2023

    • Author(s)
      Uchino Takashi、Okubo Ryo、Takubo Youji、Aoki Akiko、Wada Izumi、Hashimoto Naoki、Ikezawa Satoru、Nemoto Takahiro
    • Journal Title

      Journal of Personalized Medicine

      Volume: 13 Issue: 4 Pages: 683-683

    • DOI

      10.3390/jpm13040683

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of loneliness on suicidal ideation during the COVID-19 pandemic: findings from a cross-sectional online survey in Japan2023

    • Author(s)
      Tachikawa Hirokazu、Matsushima Midori、Midorikawa Haruhiko、Aiba Miyuki、Okubo Ryo、Tabuchi Takahiro
    • Journal Title

      BMJ Open

      Volume: 13 Issue: 5 Pages: e063363-e063363

    • DOI

      10.1136/bmjopen-2022-063363

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The diagnostic accuracy of the Edinburgh Postnatal Depression Scale without the self-harm item2023

    • Author(s)
      Chen Chong、Okubo Ryo、Okawa Sumiyo、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Journal of Psychiatric Research

      Volume: 165 Pages: 70-76

    • DOI

      10.1016/j.jpsychires.2023.07.015

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Broad impact of adverse childhood experiences on postpartum maternal mental health, child‐rearing behaviors, and child development in Japan2023

    • Author(s)
      Chen Chong、Okubo Ryo、Okawa Sumiyo、Hagiwara Kosuke、Mizumoto Tomohiro、Higuchi Naoko、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 77 Issue: 10 Pages: 569-571

    • DOI

      10.1111/pcn.13581

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Are patients with mental disorders more vulnerable to loneliness and social isolation during the COVID-19 pandemic? ? Findings from the Japan COVID-19 and Society Internet Survey2023

    • Author(s)
      Goh Keng Wee、Ishikawa Shuhei、Okubo Ryo、Kusumi Ichiro、Tabuchi Takahiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 340 Pages: 72-79

    • DOI

      10.1016/j.jad.2023.08.035

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for mother-to-infant bonding difficulties and maternal anger/rejection towards the infant in a Japanese longitudinal study2023

    • Author(s)
      Chen Chong、Okawa Sumiyo、Okubo Ryo、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 89 Pages: 103778-103778

    • DOI

      10.1016/j.ajp.2023.103778

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for abnormal glucose metabolism during antipsychotic treatment: A prospective cohort study2023

    • Author(s)
      Miyakoshi Takashi、Ishikawa Shuhei、Okubo Ryo、Hashimoto Naoki、Sato Norihiro、Kusumi Ichiro、Ito Yoichi M.
    • Journal Title

      Journal of Psychiatric Research

      Volume: 168 Pages: 149-156

    • DOI

      10.1016/j.jpsychires.2023.10.055

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between health anxiety dimensions and preventive behaviors during the COVID-19 pandemic among Japanese healthcare workers2023

    • Author(s)
      Nagao Kentaro、Yoshiike Takuya、Okubo Ryo、Matsui Kentaro、Kawamura Aoi、Izuhara Muneto、Utsumi Tomohiro、Hazumi Megumi、Shinozaki Mio、Tsuru Ayumi、Sasaki Yohei、Takeda Kazuyoshi、Komaki Hirofumi、Oi Hideki、Kim Yoshiharu、Kuriyama Kenichi、Hidehiko Takahashi、Miyama Takeshi、Nakagome Kazuyuki
    • Journal Title

      Heliyon

      Volume: 9 Issue: 11 Pages: e22176-e22176

    • DOI

      10.1016/j.heliyon.2023.e22176

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of COVID-19-related discrimination with subsequent depression and suicidal ideation in healthcare workers2023

    • Author(s)
      Narita Zui、Okubo Ryo、Sasaki Yohei、Takeda Kazuyoshi、Ohmagari Norio、Yamaguchi Koushi、Morisaki Naho、Sampei Makiko、Ishitsuka Kazue、Kojima Masayo、Nishimura Kunihiro、Inoue Manami、Yamamoto Shohei、Konishi Maki、Miyo Kengo、Mizoue Tetsuya
    • Journal Title

      Journal of Psychiatric Research

      Volume: 159 Pages: 153-158

    • DOI

      10.1016/j.jpsychires.2023.01.025

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations of parent-child exercise with family relations and parental mental health during the COVID-19 pandemic2023

    • Author(s)
      Koga Takaya、Okubo Ryo、Chen Chong、Hagiwara Kosuke、Mizumoto Tomohiro、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 324 Pages: 551-558

    • DOI

      10.1016/j.jad.2023.01.001

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The prevalence and risk factors of suicidal ideation in pregnancy and postpartum under the COVID‐19 pandemic in Japan2023

    • Author(s)
      Chen Chong、Okubo Ryo、Okawa Sumiyo、Higuchi Naoko、Nakagawa Shin、Tabuchi Takahiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: - Issue: 5 Pages: 300-301

    • DOI

      10.1111/pcn.13538

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mental health care use and related factors in adolescents and young adults with cancer2023

    • Author(s)
      Hirayama Takatoshi、Ikezawa Satoru、Okubo Ryo、Mizuta Tomoko、Iwata Shintaro、Suzuki Tatsuya
    • Journal Title

      Supportive Care in Cancer

      Volume: 31 Issue: 4

    • DOI

      10.1007/s00520-023-07708-4

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spillover effect of psychological distress from distressed to non-distressed spouse: A cohort study for midlife married couples in Japan2022

    • Author(s)
      Miyata Jun、Okubo Ryo、Tabuchi Takahiro、Iso Hiroyasu
    • Journal Title

      Journal of Affective Disorders

      Volume: 312 Pages: 252-258

    • DOI

      10.1016/j.jad.2022.06.037

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perceptions of and subjective difficulties with social cognition in schizophrenia from an internet survey: Knowledge, clinical experiences, and awareness of association with social functioning2022

    • Author(s)
      Uchino Takashi、Okubo Ryo、Takubo Youji、Aoki Akiko、Wada Izumi、Hashimoto Naoki、Ikezawa Satoru、Nemoto Takahiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 76 Issue: 9 Pages: 429-436

    • DOI

      10.1111/pcn.13435

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacological interventions for social cognitive impairments in schizophrenia: A protocol for a systematic review and network meta-analysis2022

    • Author(s)
      Yamada Yuji、Okubo Ryo、Tachimori Hisateru、Uchino Takashi、Kubota Ryotaro、Okano Hiroki、Ishikawa Shuhei、Horinouchi Toru、Takanobu Keisuke、Sawagashira Ryo、Hasegawa Yumi、Sasaki Yohei、Nishiuchi Motohiro、Kawashima Takahiro、Tomo Yui、Hashimoto Naoki、Ikezawa Satoru、Nemoto Takahiro、Watanabe Norio、Sumiyoshi Tomiki
    • Journal Title

      Frontiers in Psychology

      Volume: 13 Pages: 1-10

    • DOI

      10.3389/fpsyg.2022.878829

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID‐19‐related discrimination, PTSD symptoms, and psychological distress in healthcare workers2022

    • Author(s)
      Narita Zui、Okubo Ryo、Sasaki Yohei、Takeda Kazuyoshi、Takao Masaki、Komaki Hirofumi、Oi Hideki、Mizoue Tetsuya、Miyama Takeshi、Kim Yoshiharu
    • Journal Title

      International Journal of Mental Health Nursing

      Volume: 32 Issue: 1 Pages: 139-146

    • DOI

      10.1111/inm.13069

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Burnout and its associated factors among healthcare workers and the general working population in Japan during the COVID-19 pandemic: a nationwide cross-sectional internet-based study2022

    • Author(s)
      Matsuo Takahiro、Yoshioka Takashi、Okubo Ryo、Nagasaki Kazuya、Tabuchi Takahiro
    • Journal Title

      BMJ Open

      Volume: 12 Issue: 11 Pages: e064716-e064716

    • DOI

      10.1136/bmjopen-2022-064716

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Strong ch‐hai, a Japanese ready‐to‐drink high‐alcohol‐content beverage, and hazardous alcohol use: A nationwide cross‐sectional study2022

    • Author(s)
      Yoshioka Takashi、So Ryuhei、Takayama Atsushi、Okubo Ryo、Funada Satoshi、Takada Midori、Wakabayashi Mami、Tabuchi Takahiro
    • Journal Title

      Alcohol: Clinical and Experimental Research

      Volume: 47 Issue: 2 Pages: 285-295

    • DOI

      10.1111/acer.14991

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proposed Cut-Off Score for the Japanese Version of the Fear of Coronavirus Disease 2019 Scale (FCV-19S): Evidence from a Large-Scale National Survey in Japan2022

    • Author(s)
      Midorikawa Haruhiko、Tachikawa Hirokazu、Aiba Miyuki、Shiratori Yuki、Sugawara Daichi、Kawakami Naoaki、Okubo Ryo、Tabuchi Takahiro
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 20 Issue: 1 Pages: 429-429

    • DOI

      10.3390/ijerph20010429

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食とメンタルヘルス : ω3不飽和脂肪酸を中心に2022

    • Author(s)
      大久保亮
    • Journal Title

      医学のあゆみ

      Volume: 282 Pages: 740-744

    • Related Report
      2022 Research-status Report
  • [Presentation] Does the association between short-chain fatty acids and depressive symptoms vary with age? A large population-based study2024

    • Author(s)
      Ryo Okubo
    • Organizer
      32nd European Congress of Psychiatry
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research

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Published: 2022-04-19   Modified: 2024-12-25  

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