| Project/Area Number |
22K17847
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
張 シュ 国立研究開発法人国立長寿医療研究センター, 研究所 老年学・社会科学研究センター, 研究員 (00874471)
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| Project Period (FY) |
2022-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2025: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | risk factors / cognitive frailty / cohort / dietary diversity / nutritional approach |
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| Outline of Research at the Start |
This study uses interdisciplinary data to elucidate: 1) dietary factors that play important roles in preventing cognitive frailty; 2) possible mechanisms of any associations identified; and 3) risk factors modifying nutrition approaches for preventing and improving cognitive frailty.
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| Outline of Annual Research Achievements |
This study aims to elucidate: 1) dietary factors that play important roles in preventing cognitive frailty (CF) (through different pathways); 2) possible mechanisms of any associations identified; and 3) risk factors modifying nutrition approaches for preventing and improving CF.
My main task this year was to collect data on subjective cognitive decline using the Memory Complaint Questionnaire in Japanese (MAC-Q-J) in the NILS-LSA 10th wave survey. In addition, I examined the effects of various risk factors on the transition from robustness to CF using 14 years of cognitive function and frailty data. I found differences in the effects of different risk factors on the transition pathways in a multi-state model. This result suggests the need for targeted interventions for CF prevention.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The 10th survey is well underway and gathering useful information for further analysis. It provides useful data for defining CF in the future.
Based on the existing risk factor assessment data and 14 years of cognitive function and frailty data, I was able to secure a certain number of subjects and examine association between risk factors and CF development. The findings obtained will be submitted to international academic journals.
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| Strategy for Future Research Activity |
I will utilize the data collected using the MAC-Q in the new round of the NILS-LSA survey (10th) to more accurately determine the CF status of the participants. These data will be further analyzed.
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