• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of in silico nose for indoor odor evaluation

Research Project

Project/Area Number 22K18300
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 23:Architecture, building engineering, and related fields
Research InstitutionKyushu University

Principal Investigator

伊藤 一秀  九州大学, 総合理工学研究院, 教授 (20329220)

Co-Investigator(Kenkyū-buntansha) 久我 一喜  九州大学, 総合理工学研究院, 助教 (60905727)
Project Period (FY) 2022-06-30 – 2028-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2027: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2026: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2024: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2022: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords数値鼻 / 計算流体力学 / 生理的薬物動態 / 知覚臭気強度 / 知覚空気質
Outline of Research at the Start

嗅覚情報処理・数理モデル・流体解析を統合した全く新しいコンセプトの超高精度数値鼻を開発する.
特に,人間(ヒト)とビーグル犬(イヌ)の鼻腔詳細幾何形状と嗅粘液・嗅上皮・嗅覚受容体を数理的に再現した上で,ガス状臭気物質(低分子有機化合物)の鼻腔内輸送メカニズムを非定常流体解析と連成して高精度計算する手法を確立する.その上で,嗅上皮上の嗅粘液に対する低分子有機化合物吸着フラックスの時間変化と嗅覚受容体アクセス機構を数理的に記述する生理的薬物動態モデルを独自開発し,被験者実験データと統合することで,知覚臭気強度,容認度,知覚空気質を数値的に予測可能な数値鼻を開発する.

Outline of Annual Research Achievements

本研究では,被験者実験手法のみに依存している現状の臭い香り評価法に対し,室内空気環境設計段階(特に使用建材を選定した段階)で空間の臭い香り分布とその時間変化までを数値的に予測する超高精度数値鼻を開発する.研究2年目である2023年度は,研究計画に従って研究を推進し,以下の成果を得た.
(2-1)2022年度に作成した(嗅覚領域を詳細再現した)鼻腔モデルを統合した数値人体モデルに,(2022年度に作成した)アセトンの他,アセトアルデヒド,酢酸,アンモニアを対象とした粘膜上皮での生理的薬物動態(PBPK)モデルを開発しモデルパラメータを同定し,汎用CFDコードに実装した
(2-2)アセトンならびにアセトアルデヒドを対象としたOdour IntensityとAcceptabilityに関する被験者実験を実施し,in silicoモデルの解析結果を検証するための主観データを蓄積した.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

当初の研究計画に従って着実に研究を推進している.生理的薬物動態モデルを複数の化学物質に拡張すると共に,知覚臭気強度をモデル化するために必須となる被験者実験の実施とデータ整理まで着実に進めることが出来た.

Strategy for Future Research Activity

当初計画に従って研究を推進することが出来ている.被験者実験も着実に実施することが出来たことから,数値モデルとの統合を進めることで研究成果を蓄積する計画である.

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Comments on the Screening Results   Research-status Report
  • Research Products

    (8 results)

All 2023 2022 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Int'l Joint Research] 豪州RMIT際額(オーストラリア)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2023 Research-status Report
  • [Journal Article] In-silico decongested trial effects on the impaired breathing function of a bulldog suffering from severe brachycephalic obstructive airway syndrome2023

    • Author(s)
      Khoa Nguyen Dang、Phuong Nguyen Lu、Tani Kenji、Inthavong Kiao、Ito Kazuhide
    • Journal Title

      Computer Methods and Programs in Biomedicine

      Volume: 228 Pages: 107243-107243

    • DOI

      10.1016/j.cmpb.2022.107243

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational fluid-particle dynamics modeling of ultrafine to coarse particles deposition in the human respiratory system, down to the terminal bronchiole2023

    • Author(s)
      Khoa Nguyen Dang、Li Sixiao、Phuong Nguyen Lu、Kuga Kazuki、Yabuuchi Hidetake、Kan-O Keiko、Matsumoto Koichiro、Ito Kazuhide
    • Journal Title

      Computer Methods and Programs in Biomedicine

      Volume: 237 Pages: 107589-107589

    • DOI

      10.1016/j.cmpb.2023.107589

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A pilot numerical study of odorant transport to the olfactory region during sensory evaluations following ISO 16000-282023

    • Author(s)
      Kuga Kazuki、Hoshiyama Sara、Wargocki Pawel、Ito Kazuhide
    • Journal Title

      Building and Environment

      Volume: 245 Pages: 110868-110868

    • DOI

      10.1016/j.buildenv.2023.110868

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RESEARCH FOR DEVELOPMENT OF NUMERICAL MODEL FOR EVALUATING ODORANT IN INDOOR ENVIRONMENT: NUMERICAL IDENTIFICATION OF DIFFERENCES BETWEEN ORTHONASAL AND RETRONASAL PATHWAYS OF INHALED GAS-PHASE ACETONE IN A HUMAN RESPIRATORY TRACT2022

    • Author(s)
      HOSHIYAMA Sara、KUGA Kazuki、YOSHIDA Shinji、ITO Kazuhide
    • Journal Title

      Journal of Environmental Engineering (Transactions of AIJ)

      Volume: 87 Issue: 798 Pages: 541-549

    • DOI

      10.3130/aije.87.541

    • ISSN
      1348-0685, 1881-817X
    • Year and Date
      2022-08-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Formation of Acetone concentration distribution around breathing zone and transport efficiency to olfactory epithelium cells2022

    • Author(s)
      Sara Hoshiyama, Kazuki Kuga, Kazuhide Ito
    • Organizer
      COBEE 2022, Montiol, Canada, 2022,
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Remarks] 九州大学 伊藤一秀研究室

    • URL

      http://www.phe-kyudai.jp

    • Related Report
      2023 Research-status Report 2022 Research-status Report

URL: 

Published: 2022-07-05   Modified: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi