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Functional role of the macaque frontopolar cortex for 'thought experiment' during sleep and awake resting state

Research Project

Project/Area Number 22K18665
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Miyamoto Kentaro  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (20778047)

Co-Investigator(Kenkyū-buntansha) 山形 朋子  東邦大学, 医学部, 助教 (90584433)
Project Period (FY) 2022-06-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2023: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords思考実験 / 睡眠 / 反実仮想 / 機能的MRI / EEG / 想像 / 前頭極 / 霊長類 / メタ認知 / マカクザル
Outline of Research at the Start

私たちが寝ている時もしくは起きているが安静にしている時にはマインドワンダリングと呼ばれる、タスクの計画・実行に従事しない期間がある。ぼんやりしていると形容される状態であるが、顕著に活動が増大する脳領域も存在する。本研究は、この期間が思考実験に相当し、新しい事象に対する認知に対する認知(メタ認知・「無知の知」)に重要な、前頭極が睡眠時・安静覚醒時の経験(記憶)の再生、反実仮想、または半事実的思考に重要であり、更には睡眠時の思考実験が睡眠後の新しいタスクへの順応度を変えるというアイデアを検証する。

Outline of Final Research Achievements

Based on the results of our studies on both macaque and human subjects, we found that changes in sleep-wake states are associated with changes in activities of the frontopolar cortex, and that processes such as counterfactual thinking and hypothetical thought experiments are at work during sleep. We proposed a new model for the role of an interaction between the frontopolar cortex and anterior lateral prefrontal cortex on the mechanism of counterfactual thinking and thought experiments based on prospective metacognition (Miyamoto, Shea, Rushworth, Trends Cogn Sci, 2023).

Academic Significance and Societal Importance of the Research Achievements

前頭極は霊長類の進化の過程で、ヒトを含む霊長類でとりわけ発達した、新しい状況や問題に対処するのに重要な領域である。本研究で得られた睡眠と前頭極の機能のかかわりに関する発見により、睡眠やマインドワンダリングの機能を、単なる過去の経験の想起・記憶定着だけでなく、記憶に基づいた創造的・哲学的思考まで射程に入れて研究する新しい学術体系が生み出されると期待される。来るべきAI社会において、人間が主体性・創造性を保ちながらAIを使いこなしAIと共存するための基礎研究として、精神医療・教育等の応用分野への波及が期待される。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (19 results)

All 2024 2023 2022 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 5 results,  Invited: 11 results) Remarks (1 results)

  • [Int'l Joint Research] University of Oxford/University College London/University of London(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Neural circuits for retrospective and prospective introspection for the past present and future in macaque monkeys and humans2024

    • Author(s)
      Kentaro Miyamoto
    • Journal Title

      Neuroscience Research

      Volume: 201 Pages: 46-49

    • DOI

      10.1016/j.neures.2024.02.003

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imagining the future self through thought experiments2023

    • Author(s)
      Kentaro Miyamoto
    • Journal Title

      Trends in Cognitive Sciences

      Volume: 27 Issue: 5 Pages: 446-455

    • DOI

      10.1016/j.tics.2023.01.005

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The neural basis for metacognition-based understanding of other people's intentions and group decision-making2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      Toyota Konpon Research Institution Symposium: The role of the individual and the group in unexplored exploration
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Neural mechanisms for prediction of success by the self and others for future decision making in primates2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      The 4th International Symposium on Frontend Brain Science Yamanashi GLIA Center
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Neural Mechanisms to Anticipate Success by the Self for Future Decision Making in Humans and Macaques2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      IAS Conference on Application of New Technologies to Nonhuman Primate Models
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Macaque task fMRI: from setting up the experimental system to the publication strategy2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      5th Research Conference on New Monkey Brain Technologies
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Confidence in familiarity and novelty are merged in the posterior parietal cortices2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      JACI Brain Science Subcommittee
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Neural circuits for prediction and comparisons of the chance of success between the self and others for future decision making2024

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      Max Planck Institute for Biological Cybernetics Seminar
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cortico-subcortical dynamics during sleep-induced and sedation-induced loss/recovery of consciousness2024

    • Author(s)
      Tomoko Yamagata
    • Organizer
      ERATO UK-Japan Joint Symposium On Circadian rhythms and Sleep University of Oxford
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring the evolutionary origins of human intelligence through functional brain imaging in macaque monkeys2023

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      The 166th Conference of the Japanese Society of Veterinary Science
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Elucidating the neural circuits that predict and compare the probability of success of self and others for future decision making2023

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      NIPS symposium: Brain Mechanisms that Create Value Judgments: Can we capture the scalability of neural circuits from dots and lines?
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Investigation of the neural basis of learning and inferring others' metacognition2023

    • Author(s)
      Mingming Lin and Kentaro Miyamoto
    • Organizer
      第7回ヒト脳イメージング研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Elucidation of neural mechanisms responsible for abstract representation of objects via 'visual symbolic icons'2023

    • Author(s)
      Mika Baba and Kentaro Miyamoto
    • Organizer
      第7回ヒト脳イメージング研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 日本語版General Risk Propensity Scale(GRiPS)信頼性および妥当性の検討2023

    • Author(s)
      林 明明・宮本健太郎
    • Organizer
      日本心理学会第87回大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 霊長類の未来の成績を予測するための知覚体験に対する展望的社会メタ認知2022

    • Author(s)
      宮本 健太郎、Nadescha Trudel、Nicholas Shea、Matthew FS Rushworth
    • Organizer
      第45回日本神経科学学会大会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Prospective metacognition for subjective evaluation of future self and others in primates2022

    • Author(s)
      Kentaro Miyamoto
    • Organizer
      The 15th Annual Meeting of Chinese Neuroscience Society (CNS2022)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Where the brain weighs information for decisions

    • URL

      https://www.riken.jp/en/news_pubs/research_news/rr/20220705_1/index.html

    • Related Report
      2022 Research-status Report

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Published: 2022-07-05   Modified: 2025-01-30  

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