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The steroid hormone system in primitive bilaterians through symbiotic algae

Research Project

Project/Area Number 22K19312
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionOkayama University

Principal Investigator

Sakamoto Tatsuya  岡山大学, 環境生命自然科学学域, 教授 (10294480)

Co-Investigator(Kenkyū-buntansha) 永田 晋治  東京大学, 大学院新領域創成科学研究科, 教授 (40345179)
濱田 麻友子  岡山大学, 自然科学学域, 准教授 (40378584)
坂本 浩隆  岡山大学, 自然科学学域, 准教授 (20363971)
Project Period (FY) 2022-06-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords進化
Outline of Research at the Start

ヒトなど後口動物のステロイドホルモン系の誕生における藻類の重要性に迫る。原始的な後口動物、珍無腸動物門が新設され、そのナイカイムチョウウズムシから、ステロイド受容体を我々は発見した。これこそ祖先型と思われ、脊索動物に収束している研究を変革させうる。既存にはない新奇の内因性リガンド活性も検出したが、この原料のコレステロールの共生藻による供給の可能性も示した。以上等から「後口動物の祖先は藻類を利用して『ステロイド系→視運動の制御』を獲得した」という仮説を立てた。これに、、リガンド同定等で挑む。明らかにする機能的原点は普遍性に繋がり、本系の分化の研究~内分泌学全体へインパクトがある。

Outline of Final Research Achievements

From the primitive bilaterian, the acoel, we identified for the first time in invertebrates the glucocorticoid, mineralocorticoid, progesterone, androgen receptor family. These are thought to be ancestral types. Moreover, ligand activity was observed in the crude lipid extract fraction of this worm. It is thought that a novel primitive ligand exists. While this species also possesses cholesterol for steroids, the genes necessary for its synthesis are missing. Therefore, it is possible that symbiotic algae supply the cholesterol, similar to photosynthetic products. Also from the correlation of the related gene expression, the evolution of this glucocorticoid might have arisen to integrate these. I speculate that singularities in the course of evolution have been brought about by other organisms.

Academic Significance and Societal Importance of the Research Achievements

明らかにする機能的原点は普遍性に繋がり、本系の分化の研究~内分泌学全体へインパクトがある。リガンドが共生藻由来ならば、生体制御機構の獲得全般へも新概念の提唱となろう。飼育・解析が簡便な本ウズムシは新モデルとも期待できる。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (24 results)

All 2024 2023 2022 Other

All Int'l Joint Research (4 results) Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 17 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] マサチューセッツ大/Conte Anadromous Fish Research Center(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ボローニャ大(イタリア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ロスコフ研(フランス)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ソルボンヌ大/ロスコフ研(フランス)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Structure of putative epidermal sensory receptors in an acoel flatworm, Praesagittifera naikaiensis2024

    • Author(s)
      Sakagami Tosuke、Watanabe Kaho、Hamada Mayuko、Sakamoto Tatsuya、Hatabu Toshimitsu、Ando Motonori
    • Journal Title

      Cell and Tissue Research

      Volume: 395 Issue: 3 Pages: 299-311

    • DOI

      10.1007/s00441-024-03865-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Model systems for discovering evolutionary singularity of bilaterian physiological regulation: lessons from studies on simple/primitive flatworms2024

    • Author(s)
      Mori Shunsuke、Kobayashi Aoshi、Sakamoto Hirotaka、Hamada Mayuko、Sakamoto Tatsuya、Nakamura Ryo
    • Journal Title

      Biophysics and Physicobiology

      Volume: 21 Issue: Supplemental Pages: n/a

    • DOI

      10.2142/biophysico.bppb-v21.s012

    • ISSN
      2189-4779
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Volume X-Ray Micro-Computed Tomography Analysis of the Early Cephalized Central Nervous System in a Marine Flatworm, Stylochoplana pusilla2024

    • Author(s)
      Ikenaga Takanori、Kobayashi Aoshi、Takeuchi Akihisa、Uesugi Kentaro、Maezawa Takanobu、Shibata Norito、Sakamoto Tatsuya、Sakamoto Hirotaka
    • Journal Title

      Zoological Science

      Volume: 41 Issue: 3 Pages: 1-9

    • DOI

      10.2108/zs230082

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The evolution and characterization of the RNA interference pathways in Lophotrochozoa2024

    • Author(s)
      Federico Plazzi
    • Journal Title

      Genome Biology and Evolution

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of an additional vitellogenin gene showing hepatopancreas-specific expression in the kuruma prawn Marsupenaeus japonicus2023

    • Author(s)
      El-Desoky Marwa Said、Jogatani Tetsuya、Yamane Fumihiro、Izumikawa Kouichi、Kakinuma Makoto、Sakamoto Tatsuya、Tsutsui Naoaki
    • Journal Title

      Fisheries Science

      Volume: 89 Issue: 5 Pages: 613-623

    • DOI

      10.1007/s12562-023-01705-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chronic corticosterone exposure evokes itch hypersensitivity and sexual dysfunction in male rats: relationship between the two distinct gastrin-releasing peptide systems in the spinal cord2023

    • Author(s)
      Takanami Keiko、Morishita Makoto、Sakamoto Tatsuya、Sakamoto Hirotaka
    • Journal Title

      General and Comparative Endocrinology

      Volume: - Pages: 114289-114289

    • DOI

      10.1016/j.ygcen.2023.114289

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative PCR method to detect an extremely endangered bitterling fish (Rhodeus atremius suigensis) using environmental DNA2023

    • Author(s)
      Otsuki Kanoko、Hamada Mayuko、Koizumi Noriyuki、Sakamoto Tatsuya、Nakata Kazuyoshi
    • Journal Title

      Landscape and Ecological Engineering

      Volume: 19 Issue: 1 Pages: 79-86

    • DOI

      10.1007/s11355-022-00531-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish2023

    • Author(s)
      Y. Ogino, S. Ansai, E. Watanabe, M. Yasugi, Y. Katayama, H. Sakamoto, K. Okamoto, K. Okubo, Y. Yamamoto, I. Hara, T. Yamazaki, A. Kato, Y. Kamei, K. Naruse, K. Ohta, H. Ogino, T. Sakamoto, S. Miyagawa, T. Sato, G. Yamada, M. Baker & T. Iguchi
    • Journal Title

      Nature communications

      Volume: 14 Issue: 1 Pages: 1428-1428

    • DOI

      10.1038/s41467-023-37026-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Behavioural osmoregulation during land invasion in fish: Prandial drinking and wetting of the dry skin2022

    • Author(s)
      Katayama Yukitoshi、Tsukada Takehiro、Hyodo Susumu、Sakamoto Hirotaka、Sakamoto Tatsuya
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 12 Pages: 1-14

    • DOI

      10.1371/journal.pone.0277968

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo transcriptome analysis of the centrohelid <i>Raphidocystis contractilis</i> to identify genes involved in microtubule‐based motility2022

    • Author(s)
      Ikeda Risa、Sakagami Tosuke、Hamada Mayuko、Sakamoto Tatsuya、Hatabu Toshimitsu、Saito Noboru、Ando Motonori
    • Journal Title

      Journal of Eukaryotic Microbiology

      Volume: 70 Issue: 2

    • DOI

      10.1111/jeu.12955

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Squalomix: shark and ray genome analysis consortium and its data sharing platform2022

    • Author(s)
      Nishimura Osamu、Sakamoto Tatsuya、Semba Yasuko、Yamauchi Shinya、Yamada Kazuyuki、Nishida Kiyonori、Kiyatake Itsuki、Sato Keiichi、Hyodo Susumu、Kadota Mitsutaka、Uno Yoshinobu、Kuraku Shigehiro
    • Journal Title

      F1000Research

      Volume: 11 Pages: 1077-1077

    • DOI

      10.12688/f1000research.123591.1

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Footedness for scratching itchy eyes in rodents2022

    • Author(s)
      Katayama Yukitoshi、Miura Ayane、Sakamoto Tatsuya、Takanami Keiko、Sakamoto Hirotaka
    • Journal Title

      Proceedings of the Royal Society B: Biological Sciences

      Volume: 289 Issue: 1985 Pages: 1-9

    • DOI

      10.1098/rspb.2022.1126

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and morphological investigations on the renal mechanisms enabling euryhalinity of red stingray Hemitrygon akajei2022

    • Author(s)
      Aburatani Naotaka、Takagi Wataru、Wong Marty Kwok-Shing、Kuraku Shigehiro、Tanegashima Chiharu、Kadota Mitsutaka、Saito Kazuhiro、Godo Waichiro、Sakamoto Tatsuya、Hyodo Susumu
    • Journal Title

      Frontiers in Physiology

      Volume: 13

    • DOI

      10.3389/fphys.2022.953665

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration2022

    • Author(s)
      Kashimoto Rena、Furukawa Saya、Yamamoto Sakiya、Kamei Yasuhiro、Sakamoto Joe、Nonaka Shigenori、Watanabe Tomonobu M.、Sakamoto Tatsuya、Sakamoto Hirotaka、Satoh Akira
    • Journal Title

      iScience

      Volume: 25 Issue: 7 Pages: 104524-104524

    • DOI

      10.1016/j.isci.2022.104524

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the expression of gastrin‐releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans2022

    • Author(s)
      Takanami Keiko、Oti Takumi、Kobayashi Yasuhisa、Hasegawa Koki、Ito Takashi、Tsutsui Naoaki、Ueda Yasumasa、Carstens Earl、Sakamoto Tatsuya、Sakamoto Hirotaka
    • Journal Title

      Journal of Comparative Neurology

      Volume: 530 Issue: 16 Pages: 2804-2819

    • DOI

      10.1002/cne.25376

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vasopressin-oxytocin?type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians2022

    • Author(s)
      Kobayashi Aoshi、Hamada Mayuko、Yoshida Masa-aki、Kobayashi Yasuhisa、Tsutsui Naoaki、Sekiguchi Toshio、Matsukawa Yuta、Maejima Sho、Gingell Joseph J.、Sekiguchi Shoko、Hamamoto Ayumu、Hay Debbie L.、Morris John F.、Sakamoto Tatsuya、Sakamoto Hirotaka
    • Journal Title

      Science Advances

      Volume: 8 Issue: 9 Pages: 0311-0311

    • DOI

      10.1126/sciadv.abk0331

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Observing Phylum-Level Metazoan Diversity by Environmental DNA Analysis at the Ushimado Area in the Seto Inland Sea2022

    • Author(s)
      Kawashima Takeshi、Yoshida Masa-aki、Miyazawa Hideyuki、Nakano Hiroaki、Nakano Natumi、Sakamoto Tatsuya、Hamada Mayuko
    • Journal Title

      Zoological Science

      Volume: 39 Issue: 1 Pages: 157-165

    • DOI

      10.2108/zs210073

    • NAID

      210000186961

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] UMI, FROM NOW ON2024

    • Author(s)
      坂本竜哉
    • Organizer
      ERATO深津共生進化機構プロジェクト全体会議
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Ushimado Marine Institute Okayama University2022

    • Author(s)
      Sakamoto Tatsuya
    • Organizer
      I-MaC program @Roscoff
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Itch and its Molecular/Functional Evolution2022

    • Author(s)
      Takanami Keiko
    • Organizer
      CECE&ISFE 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2022-07-05   Modified: 2025-01-30  

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