Project/Area Number |
22K19541
|
Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
|
Research Institution | The University of Tokyo |
Principal Investigator |
Cabral Horacio 東京大学, 大学院工学系研究科(工学部), 准教授 (10533911)
|
Co-Investigator(Kenkyū-buntansha) |
持田 祐希 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (60739134)
松元 亮 東京医科歯科大学, 生体材料工学研究所, 准教授 (70436541)
宮崎 拓也 地方独立行政法人神奈川県立産業技術総合研究所, 「貼るだけ人工膵臓」プロジェクト, 研究員(任期有) (80844779)
|
Project Period (FY) |
2022-06-30 – 2024-03-31
|
Project Status |
Granted (Fiscal Year 2022)
|
Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2023: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | mRNA / in vivo CAR T / nanomedicine / immunotherapy / autoimmune disease |
Outline of Research at the Start |
Herein, we will prepare mRNA-loaded micelles for generating CAR-Tregs in vivo. In the first year, we will prepare the micelles and check the ability to generate the CAR-Tregs in vitro and in vivo. In the second year, we will test the therapeutic effect of the CAR-Tregs in a mouse model of diabetes.
|