環境中多環芳香族炭化水素によるアトピー咳嗽とその予防のための新しいバイオマーカー

• Project/Area Number: 22K19686
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Kanazawa University
• Principal Investigator: 中村 裕之 金沢大学, 医学系, 教授 (30231476)
• Co-Investigator(Kenkyū-buntansha): 原 丈介 金沢大学, 医薬保健学総合研究科, 特任准教授 (30710199) ; 大倉 徳幸 金沢大学, 附属病院, 助教 (80397215) ; 早川 和一 金沢大学, 環日本海域環境研究センター, 連携研究員 (40115267) ; 原 章規 金沢大学, 医学系, 准教授 (70507045) ; 神林 康弘 岡山理科大学, 獣医学部, 教授 (20345630) ; 辻口 博聖 金沢大学, 医学系, 特任助教 (00723090)
• Project Period (FY): 2022-06-30 – 2025-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 多環芳香族炭化水素 / アトピー咳嗽 / 疫学 / 大気汚染 / 酸化ストレス

Outline of Research at the Start

アトピー咳嗽は、これまで非定型の気管支喘息が環境中化学物質の多環芳香族炭化水素（PAH）によって引き起こされることが見出されたことから、アトピー咳嗽の発症においても、環境中化学物質が大きな危険因子である可能性があると考えた。
本研究ではこれまでに10年以上の疫学実績のある石川県志賀町において大気中化学物質、特にPAHや重金属を中心にアトピー咳嗽患者、約100人を対象とした後ろ向きコホート研究および臨床研究を実施し、曝露と疾患の因果関係を明らかにする。
発症機序としての酸化ストレス、特にスーパーオキシドの産生を軸とした病態を解明し、これをバイオマーカーとしたアトピー咳嗽の予防法を提示する。

Outline of Annual Research Achievements

持続する咳嗽を主訴とするアトピー咳嗽は、近年、急速に増加している。その基本病態は病理学的には中枢から末梢気道全体の好酸球性気道炎症であり、生理学的には気道過敏性亢進と気管支平滑筋トーヌス亢進であるが、その抜本的な原因はほとんど不明である。本研究では、新しい大気汚染物質として呼吸器疾患の原因の候補物質である多環芳香族炭化水素（PAH）とそのニトロ体（NPAH）とアトピー咳嗽の関係を明らかにするために、医療機関に外来受診しているアトピー性咳嗽、咳喘息、あるいは気管支喘息の慢性咳嗽（8週間以上の持続する咳）を呈する患者98人に対して、日々の患者の呼吸器疾患に関する咳や鼻水などの症状を日記方式で調査し、一方、集団サンプリングによってPAHやNPAH金属などの環境中化学物資の曝露を評価した。この症状と曝露量との関係を一般化推定方程式によって解析した結果、TSPとPAH濃度と咳の頻度との関係をlag0-4のGEEモデルにおいて解析したところ、BaP/BghiPとIcdP/(IcdP+BghiP)が咳の頻度と有意な負の相関を示し、ベンズ[a]アントラセン（BaA）およびピレン（Pyr）が有意なあるいはその傾向を示す正の相関を認めた。このことは、ローカルな交通車両由来のPAHが咳の発症と関係することが示唆している。アトピー咳嗽の病態をさらに解明するために、アトピー性咳嗽を有さない患者との比較などの疫学を次年度以降、実施する予定である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

アトピー性咳嗽、咳喘息あるいは気管支喘息患者98人をリクルートし、症状をモニタリングし、個々のPAHごとに、咳症状のリスクを推定できたことから、「おおむね順調に進展している。」とした。

Strategy for Future Research Activity

アトピー性咳嗽、咳喘息あるいは気管支喘息患者をさらにリクルートし、アトピー性咳嗽と非アトピー性咳嗽の患者を比較可能にすることによって、アトピー性咳嗽独自の病態がさらに明らかになると考えられる。個々のPAHごとにリスクを、アトピー性咳嗽の他の症状を目的変数、アレルギー性疾患の合併の有無やBMIなどの体格あるいは生活習慣などを共変量とした一般化推定方程式によって評価する予定である。

Research Products

• [Journal Article] Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants (2023)
  • Author(s): Zannatun Nayema, Takehiro Sato, Takayuki Kannon, Hiromasa Tsujiguchi, Kazuyoshi Hosomichi, Hiroyuki Nakamura, Atsushi Tajima
  • Journal Title: Journal of Human Genetics Volume: 68 Issue: 5 Pages: 313-319
  • DOI: 10.1038/s10038-022-01111-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial (2023)
  • Author(s): Noguchi-Shinohara M, Hamaguchi T, Sakai K, Komatsu J, Iwasa K, Horimoto M, Nakamura H, Yamada M, Ono K.
  • Journal Title: Journal of Alzheimer's Disease Volume: 91 Issue: 2 Pages: 805-814
  • DOI: 10.3233/jad-220953
  • Peer Reviewed / Open Access
• [Journal Article] Relationships among Depressive Symptoms, Body Weight, and Chronic Pain: A Cross-Sectional Analysis of the Shika Study (2023)
  • Author(s): Fukushima, Shinobu, Fumihiko Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, et al.
  • Journal Title: Behavioral Sciences Volume: 13(2) Issue: 2 Pages: 86-86
  • DOI: 10.3390/bs13020086
  • Peer Reviewed / Open Access
• [Journal Article] Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study (2023)
  • Author(s): Nakai Shingo、Suzuki Fumihiko、Okamoto Shigefumi、Miyagi Sakae、Tsujiguchi Hiromasa、Hara Akinori、et al.
  • Journal Title: Healthcare Volume: 11 Issue: 3 Pages: 314-314
  • DOI: 10.3390/healthcare11030314
  • Peer Reviewed / Open Access
• [Journal Article] Higher Intake of Vegetable Protein and Lower Intake of Animal Fats Reduce the Incidence of Diabetes in Non-Drinking Males: A Prospective Epidemiological Analysis of the Shika Study (2023)
  • Author(s): Ogawa A, Tsujiguchi H, Nakamura M, Hayashi K, Hara A, Suzuki K, Miyagi S, Kannon T, Takazawa C, Zhao J, Kambayashi Y, Shimizu Y, Shibata A, Konoshita T, Suzuki F, Tsuboi H, Tajima A, Nakamura H
  • Journal Title: Nutrients Volume: 15 Issue: 4 Pages: 1040-1040
  • DOI: 10.3390/nu15041040
  • Peer Reviewed / Open Access
• [Journal Article] Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study (2023)
  • Author(s): Tsuji Yoshika、Koga Tomohiro、Nonaka Fumiaki、Nobusue Kenichi、Kawashiri Shin-ya、Yamanashi Hirotomo、Maeda Takahiro、Arima Kazuhiko、Aoyagi Kiyoshi、Takahashi Meiko、Kawaguchi Shuji、Matsuda Fumihiko、Fujii Hiroshi、Kawano Mitsuhiro、Nakamura Hiroyuki、Kawakami Atsushi、Tamai Mami
  • Journal Title: Frontiers in Immunology Volume: 14 Pages: 1124417-1124417
  • DOI: 10.3389/fimmu.2023.1124417
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in risk factors for end‐stage kidney disease and death in type 2 diabetes: A retrospective cohort study. (2023)
  • Author(s): Oshima M, Iwata Y*, Toyama T, Kitajima S, Hara A, Sakai N, Shimizu M, Furuichi K, Haneda M, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Makino H, Wada T
  • Journal Title: J Diabetes Volume: 15 Issue: 3 Pages: 246-254
  • DOI: 10.1111/1753-0407.13367
  • Peer Reviewed / Open Access
• [Journal Article] Association between vitamin intake and chronic kidney disease according to a variant located upstream of the PTGS1 gene: A cross-sectional analysis of Shika study (2022)
  • Author(s): Kim-Oanh Pham, Hiroyuki Nakamura（21人中21番目）
  • Journal Title: Nutrients Volume: 14(10) Issue: 10 Pages: 2082-2082
  • DOI: 10.3390/nu14102082
  • Peer Reviewed / Open Access
• [Journal Article] Association between serum 25-hydroxyvitamin D concentrations, CDX2 polymorphism in promoter region of vitamin D receptor gene, and chronic pain in rural Japanese residents (2022)
  • Author(s): Keita Suzuki, Hiroyuki Nakamura（19人中19番目）
  • Journal Title: Journal of Pain Research Volume: 15 Pages: 1475-1485
  • DOI: 10.2147/jpr.s356630
  • Peer Reviewed / Open Access
• [Journal Article] Association between Dietary Fat Intake and Hyperuricemia in Men with Chronic Kidney Disease (2022)
  • Author(s): Fumika Oku, Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Kim-Oanh Pham, Fumihiko Suzuki, Sakae Miyagi, et al.
  • Journal Title: Nutrients Volume: 25 Issue: 13 Pages: 2637-2637
  • DOI: 10.3390/nu14132637
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: A cross-sectional analysis of the Shika study (2022)
  • Author(s): Atsushi Asai, Hiroyuki Nakamura（21人中21番目）
  • Journal Title: Journal of Nutritional Science Volume: 11
  • DOI: 10.1017/jns.2022.37
  • Peer Reviewed / Open Access
• [Journal Article] Different Transport Behaviors between Asian Dust and Polycyclic Aromatic Hydrocarbons in Urban Areas: Monitoring in Fukuoka and Kanazawa, Japan (2022)
  • Author(s): Kim-Oanh Pham, Akinori Hara, Jiaye Zhao, Keita Suzuki, Atsushi Matsuki, Yayoi Inomata, Hiroshi Matsuzaki, Hiroshi Odajima, Kazuichi Hayakawa, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(11) Issue: 11 Pages: 5404-5404
  • DOI: 10.3390/app12115404
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of Chemical Components of Fine Particulate Matter Observed at Fukuoka, Japan, in Spring 2020 and Their Transport Paths (2022)
  • Author(s): Ayako Yoshino, Akinori Takami, Atsushi Shimizu, Kei Sato, Kazuichi Hayakawa, Ning Tang, Kim-Oanh Pham, Akinori Hara, Hiroyuki Nakamura, Hiroshi Odajima
  • Journal Title: Applied Sciences Volume: 12(22) Issue: 22 Pages: 11400-11400
  • DOI: 10.3390/app122211400
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of Mask Wearing in Preventing the Deleterious Health Effects of the Ionic Components of PM25-Possibility Seen in Allergic Patients (2022)
  • Author(s): Hiroshi Odajima, Hiroshi Matsuzaki, Yuko Akamine, Kaoru Kojima, Yoko Murakami, Ayako Yoshino, Akinori Takami, Kazuichi Hayakawa, Akinori Hara, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(21) Issue: 21 Pages: 11185-11185
  • DOI: 10.3390/app122111185
  • Peer Reviewed / Open Access
• [Journal Article] Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference (2022)
  • Author(s): Miyajima Yuna、Karashima Shigehiro、Ogai Kazuhiro、Taniguchi Kouki、Ogura Kohei、Kawakami Masaki、Nambo Hidetaka、Kometani Mitsuhiro、Aono Daisuke、Demura Masashi、Yoneda Takashi、Tsujiguchi Hiromasa、Hara Akinori、Nakamura Hiroyuki、Okamoto Shigefumi
  • Journal Title: Frontiers in Cellular and Infection Microbiology Volume: 12 Pages: 908997-908997
  • DOI: 10.3389/fcimb.2022.908997
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between vitamin intake and resilience based on sex in middle-aged and older Japanese adults: Results of the Shika study (2022)
  • Author(s): Kuniko Sato, Fumihiko Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Takayuki Kannon, Sakae Miyagi, Keita Suzuki, Masaharu Nakamura, Chie Takazawa, Aki Shibata, Hirohito Tsuboi, Yukari Shimizu, Thao Thi Thu Nguyen, Tadashi Konoshita, Yasuki Ono, Koichi Hayashi, Atsushi Tajima, Hiroyuki Nakamura
  • Journal Title: Nutrients Volume: 14(23) Issue: 23 Pages: 5042-5042
  • DOI: 10.3390/nu14235042
  • Peer Reviewed / Open Access
• [Journal Article] Bone strength of the calcaneus Is associated with dietary calcium intake in older Japanese men, but not women (2022)
  • Author(s): Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Fumihiko Suzuki, Chie Takazawa, Masaharu Nakamura, Hirohito Tsuboi, Takayuki Kannon, Atsushi Tajima, Hiroyuki Nakamura
  • Journal Title: Nutrients Volume: 14(24) Issue: 24 Pages: 5225-5225
  • DOI: 10.3390/nu14245225
  • Peer Reviewed / Open Access
• [Journal Article] Cystatin C-based eGFR predicts cardiovascular disease in patients with overweight/obesity and hyperglycemia (2022)
  • Author(s): Suzuki K, Tsujiguchi H, Hara A, Nakamura H, Kotani K, Noda M, Yamakage H, Satoh-Asahara N, Takamura T
  • Journal Title: Obes Sci Pract Volume: 9 Issue: 1 Pages: 4-14
  • DOI: 10.1002/osp4.630
  • Peer Reviewed / Open Access
• [Journal Article] Elevated ratio of serum anandamide to arachidonic acid intake in community-dwelling women with high depressive symptoms (2022)
  • Author(s): Hirohito Tsuboi, Masahiro Matsunaga, Hiromasa Tsujiguchi, Takayuki Kannon, Kazuyoshi Hosomichi, Takehiro Sato, Atsushi Tajima, Naoko Yoshida, Akinori Hara, Hiroyuki Nakamura
  • Journal Title: Neuro endocrinology letters Volume: 43(3) Pages: 145-153
  • Peer Reviewed / Open Access
• [Journal Article] Association between cough and ambient polycyclic aromatic hydrocarbons in patients with chronic cough: an observational study in two regions of Japan (2022)
  • Author(s): Akinori Hara, Hiroshi Odajima, Hiroshi Matsuzaki, Masaki Fujimura, Tomoko Toma, Taizo Wada, Noriyuki Ohkura, JiaYe Zhao, Kim-Oanh Pham, Keita Suzuki, Hiromasa Tsujiguchi, Akinori Takami, Kazuichi Hayakawa, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(24) Issue: 24 Pages: 12505-12505
  • DOI: 10.3390/app122412505
  • Peer Reviewed / Open Access
• [Journal Article] Prospective relationship between autistic traits and nutrient intakes among Japanese children: Results of the Shika study (2022)
  • Author(s): Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Kim Oanh Pham, Keita Suzuki, Thao Thi Thu Nguyen, Yasuki Ono, Yasuhiro Kambayashi, Yukari Shimizu, Haruki Nakamura, Fumihiko Suzuki, Aki Shibata, Koichi Hayashi, Hirohito Tsuboi, Hiroyuki Nakamura
  • Journal Title: Autism Volume: 27(2) Pages: 389-401
  • Peer Reviewed / Open Access
• [Journal Article] The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women (2022)
  • Author(s): Sara Kress, Akinori Hara, Claudia Wigmann, Takehiro Sato, Keita Suzuki, Kim-Oanh Pham, Qi Zhao, Ashtyn Areal, Atsushi Tajima, Holger Schwender, Hiroyuki Nakamura, Tamara Schikowski
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19(16) Issue: 16 Pages: 9869-9869
  • DOI: 10.3390/ijerph19169869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between Social Capital and Depressive Symptoms: Differences According to Resilience and Gender in the Shika Study (2022)
  • Author(s): Kuniko Sato, Hiromasa Tsujiguchi, Fumihiko Suzuki, Akinori Hara, Takayuki Kannon, Go Muto, Daisuke Hori, Sakae Miyagi, Keita Suzuki, Masaharu Nakamura, Chie Takazawa, Tomoko Kasahara, Hirohito Tsuboi, Mie Matsui, Atsushi Tajima, Hiroyuki Nakamura
  • Journal Title: Journal of Affective Disorders Reports Volume: 10 Pages: 100421-100421
  • DOI: 10.1016/j.jadr.2022.100421
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial. (2022)
  • Author(s): Takeshita Y, Honda M, Harada K, Kita Y, Takata N, Tsujiguchi H, Tanaka T, Goto H, Nakano Y, Iida N, Arai K, Yamashita T, Mizukoshi E, Nakamura H, Kaneko S, Takamura T.
  • Journal Title: Diabetes Care. Volume: 45 Issue: 9 Pages: 2064-2075
  • DOI: 10.2337/dc21-2049
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal Variability and Risk Assessment of Atmospheric Polycyclic Aromatic Hydrocarbons and Hydroxylated Polycyclic Aromatic Hydrocarbons in Kanazawa, Japan (2022)
  • Author(s): Masato Honda, Kazuichi Hayakawa, Lulu Zhang, Ning Tang, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(19) Issue: 19 Pages: 9469-9469
  • DOI: 10.3390/app12199469
  • Peer Reviewed / Open Access
• [Journal Article] The Ionic Component of PM25 May Be Associated with Respiratory Symptoms and Peak Expiratory Flow Rate (2022)
  • Author(s): Hiroshi Odajima, Hiroshi Matsuzaki, Yuko Akamine, Kaoru Kojima, Yoko Murakami, Ayako Yoshino, Akinori Takami, Kazuichi Hayakawa, Akinori Hara, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(19) Issue: 19 Pages: 10082-10082
  • DOI: 10.3390/app121910082
  • Peer Reviewed / Open Access
• [Journal Article] Hypertension and Low Body Weight Are Associated with Depressive Symptoms Only in Females: Findings from the Shika Study (2022)
  • Author(s): Toru Yanagisawa, Fumihiko Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, Keita Suzuki, Yukari Shimizu, Thao Thi Thu Nguyen, Fumika Oku, Kuniko Sato, Masaharu Nakamura, Koichiro Hayashi, Aki Shibata, Tadashi Konoshita, Yasuhiro Kambayashi, Hirohito Tsuboi, Atsushi Tajima, Hiroyuki Nakamura
  • Journal Title: Behavioral Sciences Volume: 12(11) Issue: 11 Pages: 413-413
  • DOI: 10.3390/bs12110413
  • Peer Reviewed / Open Access
• [Journal Article] Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in Japan (2022)
  • Author(s): Azumi Ishizaki, Xiuqiong Bi, Quynh Thi Nguyen, Tomomi Maeno, Akinori Hara, Hiroyuki Nakamura, Sanae Kuramoto, Koichi Nishi, Hiroyasu Ooe, Hiroshi Ichimura
  • Journal Title: PLOS ONE Volume: 17(8) Issue: 8 Pages: e0273712-e0273712
  • DOI: 10.1371/journal.pone.0273712
  • Peer Reviewed / Open Access
• [Journal Article] Acceptability of transdermal antipsychotic patches by patients who refuse oral medication and their effectiveness in preventing recurrence of delirium: a retrospective observational study (2022)
  • Author(s): Hatta Kotaro、Usui Chie、Nakamura Hiroyuki
  • Journal Title: International Clinical Psychopharmacology Volume: 38 Issue: 1 Pages: 23-27
  • DOI: 10.1097/yic.0000000000000428
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal Study on the Association between Ambient Polycyclic Aromatic Hydrocarbons and Nasal Symptoms in Adult Japanese (2022)
  • Author(s): Jiaye Zhao, Akinori Hara, Kazuichi Hayakawa, Kim-Oanh Pham, Keita Suzuki, Hiromasa Tsujiguchi, Hiroshi Matsuzaki, Hiroshi Odajima, Akinori Takami, Hiroyuki Nakamura
  • Journal Title: Applied Sciences Volume: 12(24) Issue: 24 Pages: 12544-12544
  • DOI: 10.3390/app122412544
  • Peer Reviewed / Open Access
• [Journal Article] Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat (2022)
  • Author(s): Oo Swe Mar、Oo Hein Ko、Takayama Hiroaki、Ishii Kiyo-aki、Takeshita Yumie、Goto Hisanori、Nakano Yujiro、Kohno Susumu、Takahashi Chiaki、Nakamura Hiroyuki、Saito Yoshiro、Matsushita Mami、Okamatsu-Ogura Yuko、Saito Masayuki、Takamura Toshinari
  • Journal Title: Cell Reports Volume: 38 Issue: 13 Pages: 110566-110566
  • DOI: 10.1016/j.celrep.2022.110566
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer’s Disease: The JPSC-AD Study (2022)
  • Author(s): Noguchi-Shinohara Moeko、Yuki-Nozaki Sohshi、Abe Chiemi、et al.
  • Journal Title: Journal of Alzheimer's Disease Volume: 85 Issue: 1 Pages: 235-247
  • DOI: 10.3233/jad-215153
  • Peer Reviewed / Open Access
• [Presentation] The role of polygenic susceptibility on air pollution-associated asthma between Caucasian and Asian elderly women (2022)
  • Author(s): Sara Kress, Akinori Hara, Claudia Wigmann, Keita Suzuki, Qi Zhao, Atsushi Tajima, Hiroyuki Nakamura, Tamara Schikowski
  • Organizer: 34th Annual Conferenceof the International Societyfor Environmental Epidemiology
  • Int'l Joint Research