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Studying bone secreted molecules (osteokines) as a novel diabetes diagnostic tool

Research Project

Project/Area Number 22K20647
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0702:Biology at cellular to organismal levels, and related fields
Research InstitutionTohoku University

Principal Investigator

Marahleh Aseel  東北大学, 学際科学フロンティア研究所, 助教 (10963100)

Project Period (FY) 2022-08-31 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsBone / Diabetes / transcriptome / Proteome / Osteokines / Osteocytes / Transcriptome / Glut 1 / Skeleton / Obesity / Proteomics / Animal models / Skeletal regulation / Osteocyte / Energy metabolism / Skeletal Endocrinology
Outline of Research at the Start

In this project I will define the relationship between osteocytes and glucose uptake, its mechanism, its effect on metabolic disorders, and identify osteokines as tools for early prediction of diabetes

Outline of Final Research Achievements

Obesity and diabetes impact bones negatively and lead to bone fragility and diabetic osteoporosis. This is exacerbated by ageing and aggravated by modern societies sedentary lifestyle. Bone is an active tissue and can affect energy metabolism by secreting bone factors (osteokines). This research focused on elucidating the interaction between the two systems (bone and energy metabolism). The purpose is to investigate bone factors as novel targets for the early prediction, and diagnosis of diabetes and diabetic bone fragility. We studied bones at multiple stages of diabetes progression using gene and protein expression and imaging techniques. Our results demonstrate that bone exhibits distinctive structural difference at the early stage versus late stage of the disease which indicates that disease progression can be intercepted if diagnosed early using osteokines (bone factors) profiled at the early stage which also acts as a proxy for diagnosing diabetes disease progression.

Academic Significance and Societal Importance of the Research Achievements

Bone fragility is a serious complication of diabetes with substantial morbidity and increased fracture risk. Detecting the disease by developing early diagnostic tools reduces the need for operative intervention, increases patient's quality of life and alleviates diabetes- associated health burdens.

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (8 results)

All 2023

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] The Osteocyte and its Osteoclastogenic Potential2023

    • Author(s)
      Aseel Marahleh
    • Journal Title

      Frontiers in Endocrinology

      Volume: 14 Pages: 1121727-1121727

    • DOI

      10.3389/fendo.2023.1121727

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The transcriptomic landscape of hyperglycemic osteocytes.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Jiayi R, Ohori F, Noguchi T, Mizoguchi I
    • Organizer
      The 82nd Annual Meeting of the Japanese Orthodontic Society.
    • Related Report
      2023 Annual Research Report
  • [Presentation] Hyperglycemia Induces Extensive Alternative Splicing Changes In Osteocyte Enriched Cultures With Minimal Transcriptional Alterations.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Jiayi R, Ohori F, Noguchi T, Mizoguchi I
    • Organizer
      ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells. The American Society of Bone and Mineral Research
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Osteoimmunology in Orthodontics2023

    • Author(s)
      Aseel Marahleh
    • Organizer
      STOVIT online series, Universitas Airlangga,
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] High Glucose Induces Alternative Splicing Changes in Primary Osteocytes With Minimal Transcriptional Alterations.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Jiayi R, Ohori F, Noguchi T, Mizoguchi I
    • Organizer
      Cell Bio 2023. Boston Convention Center, Boston, MA, USA., The American Society for Cell Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Osteocytes Exhibit Extensive Alternative Splicing Changes in Response to Hyperglycemia.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Jiayi R, Ohori F, Noguchi T, Mizoguchi I
    • Organizer
      The 46th Annual Meeting of the Molecular Biology Society of Japan. Online.
    • Related Report
      2023 Annual Research Report
  • [Presentation] Metabolism and the Skeleton. What can our bones tell us?2023

    • Author(s)
      Aseel Marahleh
    • Organizer
      2022 CA+inD Winter Short-term Exchange Program Multimodal Global Leaders Development through Asian-Model Dentistry Consortium
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Skeletal Regulation of Energy Metabolism2023

    • Author(s)
      Aseel Marahleh
    • Organizer
      2023 TI-FRIS/FRIS Symposium
    • Related Report
      2022 Research-status Report

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Published: 2022-09-01   Modified: 2025-01-30  

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