| Project/Area Number |
22K20647
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0702:Biology at cellular to organismal levels, and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
Marahleh Aseel 東北大学, 学際科学フロンティア研究所, 助教 (10963100)
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Bone / Diabetes / transcriptome / Proteome / Osteokines / Osteocytes / Transcriptome / Glut 1 / Skeleton / Obesity / Proteomics / Animal models / Skeletal regulation / Osteocyte / Energy metabolism / Skeletal Endocrinology |
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| Outline of Research at the Start |
In this project I will define the relationship between osteocytes and glucose uptake, its mechanism, its effect on metabolic disorders, and identify osteokines as tools for early prediction of diabetes
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| Outline of Final Research Achievements |
Obesity and diabetes impact bones negatively and lead to bone fragility and diabetic osteoporosis. This is exacerbated by ageing and aggravated by modern societies sedentary lifestyle. Bone is an active tissue and can affect energy metabolism by secreting bone factors (osteokines). This research focused on elucidating the interaction between the two systems (bone and energy metabolism). The purpose is to investigate bone factors as novel targets for the early prediction, and diagnosis of diabetes and diabetic bone fragility. We studied bones at multiple stages of diabetes progression using gene and protein expression and imaging techniques. Our results demonstrate that bone exhibits distinctive structural difference at the early stage versus late stage of the disease which indicates that disease progression can be intercepted if diagnosed early using osteokines (bone factors) profiled at the early stage which also acts as a proxy for diagnosing diabetes disease progression.
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| Academic Significance and Societal Importance of the Research Achievements |
Bone fragility is a serious complication of diabetes with substantial morbidity and increased fracture risk. Detecting the disease by developing early diagnostic tools reduces the need for operative intervention, increases patient's quality of life and alleviates diabetes- associated health burdens.
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