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Identification of chronic stress-related subregions in the hippocampus and its monitoring

Research Project

Project/Area Number 22K20697
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0704:Neuroscience, brain sciences, and related fields
Research InstitutionTokyo University of Science

Principal Investigator

Suzuki Kanzo  東京理科大学, 先進工学部生命システム工学科, 助教 (80961961)

Project Period (FY) 2022-08-31 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsうつ病 / ストレス / 海馬 / 最初期遺伝子 / 慢性ストレス / 神経科学
Outline of Research at the Start

慢性ストレスが、うつ病などの精神疾患の発症の原因になることが示唆されている。うつ病発症に海馬の関与が示唆されているが、海馬領域内で、どの小領域や細胞群が慢性ストレスに関与するか、未だ不明な点が多い。そこで、本研究では、慢性ストレスマウスモデルを用いて、慢性ストレスに関与しうる海馬内小領域や細胞群を特定することを目的とする。

Outline of Final Research Achievements

To identify key brain subregions in the hippocampus of mice that are involved in chronic stress, in this study, we chronically applied stress to mice and analyzed the expressions of neuronal activity markers immediately early genes. Initially, we provided a chronic social defeat stress mouse model. In addition, corticosterone was chronically administrated to mice since corticosterone is one of the stress hormones. We observed that chronic stressed mice shows depressive-like or anxiety-like behaviors. Based on the results of immediate early gene expression, we find that the dentate gyrus of the hippocampus is one of brain areas involved in chronic stress. These findings may uncover key mechanisms of the pathophysiology of depression.

Academic Significance and Societal Importance of the Research Achievements

うつ病を含む精神疾患の発症のメカニズムは未だ不明な点が多い。本研究で同定した海馬歯状回はヒトうつ病の病態と関りがあることが示唆されている。今後、神経回路レベルまで解析を進める、慢性ストレスにおける歯状回を中心とした神経回路基盤を理解することにより、うつ病の病態の理解や治療法の開発の一端となることが期待される。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 2022

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results)

  • [Journal Article] Ketamine: Mechanisms and Relevance to Treatment of Depression2024

    • Author(s)
      Kim Ji-Woon、Suzuki Kanzo、Kavalali Ege T.、Monteggia Lisa M.
    • Journal Title

      Annual Review of Medicine

      Volume: 75 Issue: 1 Pages: 129-143

    • DOI

      10.1146/annurev-med-051322-120608

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors2023

    • Author(s)
      Matsuura Sumire、Nishimoto Yuki、Endo Akane、Shiraki Hirono、Suzuki Kanzo、Segi-Nishida Eri
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 9 Pages: 1176-1183

    • DOI

      10.1248/bpb.b22-00729

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-09-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bridging rapid and sustained antidepressant effects of ketamine2023

    • Author(s)
      Kim Ji-Woon、Suzuki Kanzo、Kavalali Ege T.、Monteggia Lisa M.
    • Journal Title

      Trends in Molecular Medicine

      Volume: 29 Issue: 5 Pages: 364-375

    • DOI

      10.1016/j.molmed.2023.02.003

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process2023

    • Author(s)
      Kasakura Nanami、Murata Yuka、Shindo Asuka、Kitaoka Shiho、Furuyashiki Tomoyuki、Suzuki Kanzo、Segi-Nishida Eri
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17 Pages: 1178555-1178555

    • DOI

      10.3389/fnins.2023.1178555

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of adult-born and mature neurons in stress response and antidepressant action in the dentate gyrus of the hippocampus2022

    • Author(s)
      Segi-Nishida Eri、Suzuki Kanzo
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 10-15

    • DOI

      10.1016/j.neures.2022.08.010

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 慢性ストレスに関わる海馬歯状回の機能解明2023

    • Author(s)
      渡邊 琴美、鈴木 敢三、中村 健太、瀬木(西田) 恵里
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] アデノ随伴ウイルスベクター血清型 rh10 精製の試み2023

    • Author(s)
      田村 直紀、鈴木 敢三、白木 寛乃、瀬木-西田 恵里
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] コルチコステロンによるストレス応答のメカニズム解明2023

    • Author(s)
      白木 寛乃、鈴木 敢三、瀬木-西田 恵里
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ニューロトロフィン3過剰発現が海馬歯状回に与える影響の探索2023

    • Author(s)
      笠倉 奈々美、村田 優花、進藤 あす夏、北岡 志保、古屋敷 智之、鈴木 敢三、瀬木-西田 恵里
    • Organizer
      第97回日本薬理学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 海馬における抗うつ効果に関わる転写因子CREBの役割2023

    • Author(s)
      油井 清子、神田 豊、沓澤 美緒、鈴木 敢三、瀬木-西田 恵里
    • Organizer
      第97回日本薬理学会年会
    • Related Report
      2023 Annual Research Report

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Published: 2022-09-01   Modified: 2025-01-30  

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