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Endocrine Insights into Post-COVID-19 Fatigue

Research Project

Project/Area Number 22K20927
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0904:Internal medicine of the bio-information integration and related fields
Research InstitutionOkayama University

Principal Investigator

Otsuka Yuki  岡山大学, 大学病院, 助教 (20963036)

Project Period (FY) 2022-08-31 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords新型コロナウイルス感染症(COVID-19) / COVID-19 罹患後症状 / 筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS) / 全身倦怠感 / 血清フェリチン / 筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS) / 新型コロナウイルス感染症 / COVID-19 / Post COVID-19 condition
Outline of Research at the Start

新型コロナウイルス感染症(COVID-19)の罹患後に少なくとも1/3の患者が長期間持続する種々の症状(Post COVID-19 condition:PCC)に悩まされているもその病態はいまだ明らかではなく、収束の兆しが見えないCOVID-19流行下で多くの患者を苦しめ社会問題となっている。本研究ではPCCと内分泌・代謝疾患との症状の共通性に着目しその病態解明を目指す。

Outline of Final Research Achievements

The severity of fatigue, which is the most common symptom of Post COVID-19 Condition (PCC), varies among cases, with some severe cases progressing to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Identifying specific test abnormalities has been challenging, and finding objective indicators useful for evaluation and prognosis prediction has been an urgent issue in PCC treatment.
Therefore, this study conducted a comprehensive examination of patients visitting our PCC clinic. It identified elevated serum ferritin levels in PCC patients who met the criteria for ME/CFS and found a correlation with decreased quality of life. Additional endocrine investigations suggested that these changes reflect PCC-specific alterations.

Academic Significance and Societal Importance of the Research Achievements

従来のME/CFSでは鉄欠乏などの病態からフェリチンはむしろ低値であると報告されていることを考慮すると、本研究で得られた倦怠感患者におけるフェリチン高値はPCC特有の変化を反映している可能性が示唆された。
成長ホルモン分泌などとの関連も示唆され、PCC病態やそれによる倦怠感の背景に少なくとも部分的には内分泌学的機序も存在していると思われ、PCC病態解明の足掛かりになると思われた。
血清フェリチンの上昇はPCCにおけるQOLの低下とも関連しており、将来的に、臨床経過やフェリチン値の推移との関連も検討することで、診断基準・予後指標開発の糸口になると考えている。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (12 results)

All 2024 2023 2022

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Relevance of complement immunity with brain fog in patients with long COVID2024

    • Author(s)
      Hagiya Hideharu、Tokumasu Kazuki、Otsuka Yuki、Sunada Naruhiko、Nakano Yasuhiro、Honda Hiroyuki、Furukawa Masanori、Otsuka Fumio
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 30 Issue: 3 Pages: 236-241

    • DOI

      10.1016/j.jiac.2023.10.016

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID-19後遺症に伴う頭痛がQOLと内分泌機能へ与える影響2024

    • Author(s)
      藤田佳奈、大塚勇輝、砂田匠彦、本多寛之、徳増一樹、中野靖浩、櫻田泰江、松田祐依、長谷川徹、小比賀美香子、萩谷英大、大塚文男
    • Journal Title

      日本内分泌学会雑誌

      Volume: in press

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Utility of Serum Ferritin for Predicting Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Patients with Long COVID2023

    • Author(s)
      Yamamoto Yukichika、Otsuka Yuki、Tokumasu Kazuki、Sunada Naruhiko、Nakano Yasuhiro、Honda Hiroyuki、Sakurada Yasue、Hasegawa Toru、Hagiya Hideharu、Otsuka Fumio
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 14 Pages: 4737-4737

    • DOI

      10.3390/jcm12144737

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Manifestation of Headache Affecting Quality of Life in Long COVID Patients2023

    • Author(s)
      Fujita Kana、Otsuka Yuki、Sunada Naruhiko、Honda Hiroyuki、Tokumasu Kazuki、Nakano Yasuhiro、Sakurada Yasue、Obika Mikako、Hagiya Hideharu、Otsuka Fumio
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 10 Pages: 3533-3533

    • DOI

      10.3390/jcm12103533

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 内分泌視点から捉えたCOVID-19罹患後の倦怠感の機序とその解明2023

    • Author(s)
      大塚 勇輝 , 徳増 一樹 , 大塚 文男
    • Journal Title

      Medical Science Digest

      Volume: 49 Pages: 385-387

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Trends in Long COVID Symptoms in Japanese Teenage Patients2023

    • Author(s)
      Sakurada Yasue、Otsuka Yuki、Tokumasu Kazuki、Sunada Naruhiko、Honda Hiroyuki、Nakano Yasuhiro、Matsuda Yui、Hasegawa Toru、Ochi Kanako、Hagiya Hideharu、Ueda Keigo、Kataoka Hitomi、Otsuka Fumio
    • Journal Title

      Medicina

      Volume: 59 Issue: 2 Pages: 261-261

    • DOI

      10.3390/medicina59020261

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of endocrine dysfunction in post coronavirus disease 2019 (COVID-19) condition2022

    • Author(s)
      Yuki Otsuka and Fumio Otsuka
    • Journal Title

      Endocrine Journal

      Volume: 69 Issue: 11 Pages: 1357-1357

    • DOI

      10.1507/endocrj.EJ22-0459

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Possible Markers For Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Developed In Long Covid:Utility Of Serum Ferritin And Insulin-like Growth Factor-I2023

    • Author(s)
      Yukichika Yamamoto , Yuki Otsuka , Kazoki Tokumasu , Naruhiko Sunada , Yasuhiro Nakano , Hiroyuki Honda , Yasue Sakurada , Toru Hasegawa , Hideharu Hagiya , Fumio Otsuka
    • Organizer
      ENDO 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COVID-19後遺症に伴う頭痛がQOLと内分泌機能へ与える影響2023

    • Author(s)
      藤田佳奈、大塚勇輝、砂田匠彦、本多寛之、徳増一樹、中野靖浩、櫻田泰江、松田祐依、長谷川徹、小比賀美香子、萩谷英大、大塚文男
    • Organizer
      第33回臨床内分泌代謝Update
    • Related Report
      2023 Annual Research Report
  • [Presentation] COVID-19後遺症に伴う頭痛がQOLと内分泌機能へ与える影響2023

    • Author(s)
      藤田佳奈、大塚勇輝、砂田匠彦、本多寛之、徳増一樹、中野靖浩、櫻田泰江、松田祐依、長谷川徹、小比賀美香子、萩谷英大、大塚文男
    • Organizer
      第49日本神経内分泌学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] COVID-19罹患後にME/CFSに移行する症例の臨床的特徴:血清ferritinと内分泌系に注目した検討2023

    • Author(s)
      山本幸近、大塚勇輝、徳増一樹、萩谷英大、砂田匠彦、本多寛之、中野靖浩、櫻田泰江、松田祐依、長谷川徹、長谷川功、小比賀美香子、植田圭吾、片岡仁美、大塚文男
    • Organizer
      第26回日本病院総合診療医学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 慢性疲労症候群に移行しうるコロナ後遺症に見られる血清学的特徴:内分泌学的視点から2022

    • Author(s)
      山本幸近, 大塚勇輝, 徳増一樹, 萩谷英大, 砂田匠彦, 本多寛之, 中野靖浩, 櫻田泰江, 松田祐依, 長谷川徹, 長谷川功, 小比賀美香子, 植田圭吾, 片岡仁美, 大塚文男
    • Organizer
      第48回日本神経内分泌学会学術集会
    • Related Report
      2022 Research-status Report

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Published: 2022-09-01   Modified: 2025-01-30  

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