| Project/Area Number |
22K21117
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0908:Society medicine, nursing, and related fields
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Melanoma / Melanin / Acetaldehyde / Ethanol / ALDH2 / rs671 / Melanocyte / Keratinocyte / Acetaldehyyde / MITF / Melanocytes / Keratinocytes / Alcohol / Cancer / ALM |
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| Outline of Research at the Start |
Is Acral Lentiginous Melanoma acetaldehyde-related cancer?
Is there any positive correlation between the ALDH2 rs671 polymorphism and alcohol consumption promoting ALM in humans: Acetaldehyde-induced palmoplantar melanin highly accumulates in the melanocytes due to DKK-1, which causes intracellular stress and promotes cancer initiation?
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| Outline of Final Research Achievements |
Melanoma,is influenced by genetic factors like the ALDH2rs671 polymorphism and lifestyle choices.This study examined acetaldehyde's effect on melanin synthesis and gene expression in melanocytes, particularly in ALDH2rs671 carriers.
Treatment with acetaldehyde,α-Melanocyte stimulating hormone, and ethanol increased melanin synthesis and ALDH2 and Tyrosinase gene expression, suggesting pathways involving oxidative stress. These findings highlight genetic and lifestyle risk factors for Melanoma, especially in East Asians with a high frequency of ALDH2rs671.
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| Academic Significance and Societal Importance of the Research Achievements |
The study underscores the roles of acetaldehyde, ethanol levels, and specific gene expressions in melanogenesis of Melanoma. It highlights the increased risk of melanoma and Melanoma by accumulating acetaldehyde from alcohol consumption,
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