| Project/Area Number |
22K21301
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
1002:Human informatics, applied informatics and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | RNA modeling / Cells reprogramming / Simulation / Macrophages / Immunology / multiomics / Expression estimation / ATAC-seq / RNA-seq / Macrophages polarization / Bioinformatics / Cells-reprogramming / Multiomics / RNA-velocity / Single-cell / Cell-fate |
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| Outline of Research at the Start |
By using computational techniques and genomics information, I aim to develop a computational method to analyze the differentiation processes of cells. The resulting computational methodology could be used for exploratory analysis of cell states, a key feature to improve gene therapy.
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| Outline of Final Research Achievements |
We developed a model to understand gene behavior in immune cells called macrophages. By focusing on genes that preserved a history of their changes (hysteresis genes), we created a method to predict how these genes behave during cell reprogramming. Our model accurately simulated gene activity, helping us explore how immune cells adapt. This research could improve our understanding of immune responses related to macrophages and lead to better cancer treatments.
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| Academic Significance and Societal Importance of the Research Achievements |
Our research helps us understand how immune cells called macrophages change and adapt. This knowledge can lead to better cancer treatments by improving how we predict and influence immune responses. Ultimately, it can enhance our ability to fight diseases and improve public health.
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