• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Label-free volumetric microscopy for visualizing intracellular motility of tumor cell culture

Research Project

Project/Area Number 22KF0058
Project/Area Number (Other) 22F22355 (2022)
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeMulti-year Fund (2023)
Single-year Grants (2022)
Section外国
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

安野 嘉晃  筑波大学, 医学医療系, 教授 (10344871)

Co-Investigator(Kenkyū-buntansha) HOSSEIN IBRAHIM  筑波大学, 医学医療系, 外国人特別研究員
Project Period (FY) 2023-03-08 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2024: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2023: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2022: ¥500,000 (Direct Cost: ¥500,000)
KeywordsDynamic OCT / Intra-tissue activity / Tumor spheroid imaging / Drug testing / Label-free oncology / Ex-vivo tissue functions / Tumor spheroid / Anti-cancer drug test / Cancer diagnosis
Outline of Research at the Start

This research project aims to develop a multifunctional Optical Coherence Tomography microscope (OCM) for anti-cancer drug development and cancer diagnosis. The basic technology is OCM and our proposed extensions, including dynamics (tissue activity) imaging, polarization imaging (for collagen and fibrous orientation visualization), and tissue mechanical properties imaging.Pre-clinical studies,including 3D cell culture (tumor spheroid) based anti-cancer drugs investigation, ex-vivo cancer biopsies and in-vivo animal tumor models assessment will be performed using the proposed OCM.

Outline of Annual Research Achievements

In FY 2023, our proposed OCT microscope was successfully used for anti-cancer drug response evaluation of the tumor spheroid. The results of two major drug response studies were published as journal papers. The first includes the evaluation of the drug-response patterns of human breast and human colon cancer spheroids, while the second paper involves drug-type dependent response pattern evaluation of human breast cancer spheroid.
Development of an integrated microscope of dynamic OCT and cell cultivation chamber has been conducted in FY2023. It allowed longitudinal time-lapse imaging over 100 hours of single tumor spheroid and successfully revealed the fine temporal and spatial responses of human breast cancer spheroids to different anti-cancer drugs. The results of this research have been presented at an international conference (Photonics West, BiOS 2024).
A close collaboration research with the members in the host laboratory was conducted. It includes evaluating the renal tubular function and morphology of mouse kidneys, developing a new dynamic OCT algorithm for quantitative assessment of intracellular activities, developing an in-vivo dynamic OCT method using hardware and software motion suppression methods, neural network-based high-speed dynamic OCT imaging and tissue density estimation. In addition, an investigation of the dynamic OCT signal properties and its relation to intracellular activities was conducted. The results of these researches were published either as co-authoring journal papers or presented at international and domestic conferences.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

So far, we believe that the project progress goes smoothly. This was confirmed by the research achievements as follows. Two journal papers demonstrating the success of the proposed OCT microscope for the anti-cancer drug response assessment of tumor spheroid were first authored by the JSPS fellow and published in FY2023. The results were also presented in several international and domestic conferences presentations.
In FY2023, the JSPS fellow also successfully developed an integrated microscopic system of OCT microscope and cultivation chamber for longitudinal tumor spheroid drug response assessment. The time-lapse drug response imaging of tumor spheroid was performed over 100 hours. The results were promising and further brings the proposed OCT microscope to practical use as a tool for tumor spheroid based anti-cancer. The results and presented in an international conference and are going to be published as a journal paper in FY2024.
In addition, several ongoing researches, including developing several functional extensions of the proposed OCT microscope, are done collaboratively with the host laboratory members. The JSPS fellow is actively involved in these researches and was included as a coauthor for several papers and conference presentations.

Strategy for Future Research Activity

In FY2024, I’m going to proceed with the development of the integrated dynamic OCT microscope and cell cultivation chamber. Several experiments and studies are going to be conducted to demonstrate the utility of this integrated system for longitudinal time-lapse evaluation of the tumor spheroid drug response. The results of this study will be published as a journal paper.
More quantitative evaluation of the tissue activity, including quantification of the tumor spheroid tissue activity alteration under anti-cancer drug administration, will be conducted using our newly proposed dynamic OCT algorithm.
We will proceed with the development of in-vivo dynamic OCT technique using a hybrid hardware and software motion suppression method and integrate it with our OCT microscope.
Tissue microstructure evaluation via polarization analysis will be integrated into our OCT microscope. An optic axis orientation algorithm, which is newly developed in the host laboratory is going to be adapted to the proposed OCT microscope. It will allow the assessment of fibrous structures and extracellular matrix abnormalities.
The above-mentioned developments will increase the tissue specificity of our proposed OCT microscope. Using the proposed microscope, we are going to perform several pre-clinical studies including longitudinal drug type- and drug concertation-dependent tumor spheroid response pattern evaluation, ex-vivo tissue biopsies investigation, and in-vivo drug response evaluation of small animal (mouse and zebrafish) tumor models will be investigated.

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Annual Research Report
  • Research Products

    (38 results)

All 2024 2023 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 22 results) Remarks (1 results)

  • [Int'l Joint Research] Damietta University(エジプト)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] National Taiwan University/Chang Gung University(その他の国・地域)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Medical University of Vienna(オーストリア)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography2024

    • Author(s)
      Abd El-Sadek Ibrahim、Morishita Rion、Mori Tomoko、Makita Shuichi、Mukherjee Pradipta、Matsusaka Satoshi、Yasuno Yoshiaki
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 3366-3366

    • DOI

      10.1038/s41598-024-53171-4

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography2023

    • Author(s)
      Abd El-Sadek Ibrahim、Shen Larina Tzu-Wei、Mori Tomoko、Makita Shuichi、Mukherjee Pradipta、Lichtenegger Antonia、Matsusaka Satoshi、Yasuno Yoshiaki
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 15377-15377

    • DOI

      10.1038/s41598-023-41846-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Label-free intratissue activity imaging of alveolar organoids with dynamic optical coherence tomography2023

    • Author(s)
      Morishita Rion、Suzuki Toshio、Mukherjee Pradipta、Abd El-Sadek Ibrahim、Lim Yiheng、Lichtenegger Antonia、Makita Shuichi、Tomita Kiriko、Yamamoto Yuki、Nagamoto Tetsuharu、Yasuno Yoshiaki
    • Journal Title

      Biomedical Optics Express

      Volume: 14 Issue: 5 Pages: 2333-2333

    • DOI

      10.1364/boe.488097

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging2023

    • Author(s)
      Tomita Kiriko、Makita Shuichi、Fukutake Naoki、Morishita Rion、Abd El-Sadek Ibrahim、Mukherjee Pradipta、Lichtenegger Antonia、Tamaoki Junya、Bian Lixuan、Kobayashi Makoto、Mori Tomoko、Matsusaka Satoshi、Yasuno Yoshiaki
    • Journal Title

      Biomedical Optics Express

      Volume: 14 Issue: 7 Pages: 3100-3100

    • DOI

      10.1364/boe.491510

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renal tubular function and morphology revealed in kidney without labeling using three-dimensional dynamic optical coherence tomography2023

    • Author(s)
      Mukherjee Pradipta、Fukuda Shinichi、Lukmanto Donny、Tran Thi Hang、Okada Kosuke、Makita Shuichi、El-Sadek Ibrahim Abd、Lim Yiheng、Yasuno Yoshiaki
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 15324-15324

    • DOI

      10.1038/s41598-023-42559-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Longitudinal drug response imaging of tumor spheroids using dynamic optical coherence tomography in conjunction with cell cultivation2024

    • Author(s)
      Ibrahim G. Abd El-Sadek, Rion Morishita, Masato Iwatsuki, Atsuko Furukawa, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Dynamics and Fluctuations in Biomedical Photonics XXI
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Longitudinal drug response imaging of tumor spheroids using dynamic optical coherence tomography in conjunction with cell cultivation2024

    • Author(s)
      Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Kosuke Okada, Thi Hang Tran, Ibrahim Abd El-Sadek, Shuichi Makita, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Dynamics and Fluctuations in Biomedical Photonics XXI
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wavelength and resolution dependency of dynamic optical coherence tomography2024

    • Author(s)
      Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Label-free Biomedical Imaging and Sensing (LBIS) 2024
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography2024

    • Author(s)
      Yu Guo, Rion Morishita, Ibrahim G. Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Photonics in Dermatology and Plastic Surgery 2024
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Deep-learning-based high-speed volumetric dynamic optical coherence tomography2024

    • Author(s)
      Yusong Liu, Ibrahim Abd El-Sadek, Shuichi Makita, Tomoko Mori, Atsuko Furukawa, Satoshi Matsusaka, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characterizing intracellular activities of dynamic optical coherence tomography: a mathematical modeling approach2024

    • Author(s)
      Yuanke Feng, Shumpei Fujimura, Yiheng Lim, Thitiya Seesan, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Label-free Biomedical Imaging and Sensing (LBIS) 2024
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vivo dynamic optical coherence tomography with hardware- and software-based motion correction2024

    • Author(s)
      Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, and Yoshiaki Yasuno
    • Organizer
      Photonics West, BiOS, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative dynamic optical coherence tomography by multi-time-window signal intensity variance2024

    • Author(s)
      Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Tanatchaya Seesan, Yiheng Lim, Tomoko Mori, Atsuko Furukawa, Satoshi Matsusaka, Shuichi Makita, and Yoshiaki Yasuno "Quantitative dynamic optical coherence tomography by multi-time-window signal intensity variance
    • Organizer
      Photonics West, BiOS, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Human-derived tumor-spheroid-based anti-cancer drugs testing using dynamic optical coherence tomography2023

    • Author(s)
      Ibrahim Abd El-Sadek, Rion Morishita, Tomoko Mori, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, and Yoshiaki Yasuno
    • Organizer
      European Conferences on Biomedical Optics, Optical Coherence Imaging Techniques and Imaging in Scattering Media
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Label-free intra-tissue activity imaging of alveolar organoid with three-dimensional dynamic optical coherence tomography2023

    • Author(s)
      Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Toshio Suzuki, Antonia Lichtenegger, YiHeng Lim, Yiqiang Zhu, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, and Yoshiaki Yasuno
    • Organizer
      European Conferences on Biomedical Optics, Optical Coherence Imaging Techniques and Imaging in Scattering Media
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] New formulation of OCT for analytical signal-to-speckle separation and volumetric differential contrast imaging2023

    • Author(s)
      Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, and Yoshiaki Yasuno
    • Organizer
      European Conferences on Biomedical Optics, Optical Coherence Imaging Techniques and Imaging in Scattering Media
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Longitudinal imaging of tumor spheroid response to anti-cancer drugs by dynamic optical coherence tomography integrated with cultivation chamber2023

    • Author(s)
      Ibrahim Abd El-Sadek,Rion Morishita,Masato Iwatsuki,Atsuko Furukawa,Shuichi Makita,Pradipta Mukherjee, Satoshi Matsusaka,Yoshiaki Yasuno
    • Organizer
      Optics and Photonics Japan
    • Related Report
      2023 Research-status Report
  • [Presentation] Investigating the wavelength and resolution dependency in dynamic optical coherence tomography signals2023

    • Author(s)
      Shumpei Fujimura,Ibrahim Abd El-Sadek, Pradipta Mukherjee,Yiheng Lim,Lida Zhu,Rion Morishita,Yuanke Feng,Yoshiaki Yasuno
    • Organizer
      Optics and Photonics Japan
    • Related Report
      2023 Research-status Report
  • [Presentation] Modeling intracellular dynamics and its relation to dynamic optical coherence tomography signals2023

    • Author(s)
      Feng Yuanke,Shumpei Fujimura,Yiheng Lim,Thitiya Seesan,Rion Morishita,Ibrahim Abd El-Sadek,Pradipta Mukherjee,Yoshiaki Yasuno
    • Organizer
      Optics and Photonics Japan
    • Related Report
      2023 Research-status Report
  • [Presentation] Quantitative intra-tissue activity imaging technique for evaluating in vitro cell culture samples by optical coherence tomography2023

    • Author(s)
      Rion Morishita, Toshio Suzuki, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Tanatchaya Seesan, Yiheng Lim, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Yoshiaki Yasuno
    • Organizer
      The Japan Society of Applied Physics (JSAP) autumn meeting
    • Related Report
      2023 Research-status Report
  • [Presentation] Deep learning based high-speed three-dimensional dynamic optical coherence tomography generation for tumor spheroid evaluation2023

    • Author(s)
      Yusong Liu, Ibrahim Abd El-Sadek, Shuichi Makita, Tomoko Mori, Atsuko Furukawa, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      The Japan Society of Applied Physics (JSAP) autumn meeting
    • Related Report
      2023 Research-status Report
  • [Presentation] Assessing the effect of metabolic inhibitor drugs on liver functionality with dynamic optical coherence tomography2023

    • Author(s)
      Pradipta Mukherjee, Donny Lukmanto, Shinichi Fukuda, Toshiharu Yamashita, Kosuke Okada, Thi Hang Tran, Ibrahim Abd El-Sadek, Shuichi Makita, Yoshiaki Yasuno
    • Organizer
      The Japan Society of Applied Physics (JSAP) autumn meeting
    • Related Report
      2023 Research-status Report
  • [Presentation] In vivo dynamic optical coherence tomography with hardware- and software-based motion correction methods2023

    • Author(s)
      YU GUO, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno
    • Organizer
      The Japan Society of Applied Physics (JSAP) autumn meeting
    • Related Report
      2023 Research-status Report
  • [Presentation] Dynamic optical coherence tomography for tumor-spheroid-based anti-cancer-drug testing2023

    • Author(s)
      Ibrahim Abd El-Sadek, Rion Morishita, Tomoko Mori, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      Dynamics and Fluctuations in Biomedical Photonics XX
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Label-free dynamic OCT (D-OCT) based evaluation of tumor spheroids2023

    • Author(s)
      Ibrahim Abd El-Sadek, Rion Morishita, Tomoko Mori, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic OCT to visualize development of cotyledon vessels in sprouts2023

    • Author(s)
      Y. Lim, S. Kojima, P. Mukherjee, I. Abd El-Sadek, S. Makita, Y. Yasuno
    • Organizer
      Label-free Biomedical Imaging and Sensing (LBIS) 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improving the estimation accuracy of the scatterer density estimation by accounting for the spatial property of the noise in optical coherence tomography2023

    • Author(s)
      Thitiya Seesan, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Yiheng Lim, Shuichi Makita, Prathan Buranasiri, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Volumetric differential contrast imaging by computationally augmented optical coherence tomography microscopy2023

    • Author(s)
      Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtengger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      Label-free Biomedical Imaging and Sensing (LBIS) 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography2023

    • Author(s)
      Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Yiheng Lim, Yoshiaki Yasuno
    • Organizer
      Dynamics and Fluctuations in Biomedical Photonics XX
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Label-free ex-vivo animal tissue metabolism investigation using dynamic optical coherence tomography2023

    • Author(s)
      Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Low- and high-resolution volumetric dynamic optical coherence tomography of in vitro cell cultures2023

    • Author(s)
      Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Tomoko Mori, Suzuki Toshio, Antonia Lichtengger, Lim Yi Heng, Zhu Yiqiang, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Disperse scatterer model of OCT and its application to design volumetric differential contrast imaging2023

    • Author(s)
      Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tmoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography2023

    • Author(s)
      Antonia Lichtenegger, Junya Tamaoki, Pradipta Mukherjee, Roxane Licandro, Lida Zhu, Tomoko Mori, Rion Morishita, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Satoshi Matsusaka, Martin Distel, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno
    • Organizer
      Label-free Biomedical Imaging and Sensing (LBIS) 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motion-immune digital refocusing of point-scanning optical coherence tomography using Lissajous scan for in vivo imaging2023

    • Author(s)
      Shuichi Makita, Lida Zhu, Pradipta Mukherjee, Yiheng Lim, Rion Morishita, Ibrahim Abd El-Sadek, Yoshiaki Yasuno
    • Organizer
      Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 筑波大学研究室ホームページ

    • URL

      https://cog-news.blogspot.com/

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2022-11-17   Modified: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi