| Project/Area Number |
22KF0385
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| Project/Area Number (Other) |
22F21764 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 外国 |
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| Review Section |
Basic Section 32020:Functional solid state chemistry-related
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Labuta Jan 国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 主任研究員 (00720690)
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| Co-Investigator(Kenkyū-buntansha) |
VELYCHKIVSKA NADIIA 国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 外国人特別研究員
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| Project Period (FY) |
2023-03-08 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2023: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2022: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Polymers / Hydrogel / Energy storage / Supercapacitor / Porosity / Fluorescence / NADPH / Bioorthogonal chemistry / Porphyrins / Phase separation / Sensing |
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| Outline of Research at the Start |
This research aims to design and synthesize stimuli-responsive porphyrin-polymer conjugates. These conjugates comprise a hydrophilic biocompatible polymer with a photoactive porphyrin unit. The physicochemical properties of these molecules will be studied. In particular, the possibility of their use as photodynamic therapy (PDT) agents (i.e. singlet oxygen generators for cancer treatment). These molecules with a dual porphyrin-polymer nature are expected to be useful for various sensing (pH, anion, impurity) or imaging (MRI) applications.
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| Outline of Annual Research Achievements |
The investigated objectives were stretched to the field of hydrogels. We synthesized an ultrahigh surface area hierarchically porous carbon materials, prepared by potassium carbonate activation of polyacrylamide－hydroxy propyl cellulose hydrogel at high temperatures (500－900 °C) and explored their energy storage performances. The carbon material obtained has an ultrahigh surface area of 3387.2 m2 g-1 and a large pore volume of 1.963 cm3 g-1. The material showed an excellent supercapacitance performance (545.5 F g-1 at 1 A g-1 current density) with superior rate capability and an outstanding cycling stability of 96.3% after 5000 charge－discharge cycles. The electrochemical properties indicate that hierarchically porous carbons obtained from hydrogels are promising materials for high-performance supercapacitor applications.
Furthermore, we have used the kinetic schemes developed in 2022 (Scientific Reports, 2022, 12:17369, 1-15) to study the kinetics of the ubiquinone-rhodol (Q-Rh) fluorescence probe. The Q-Rh probe was used to monitor the activation of nicotinamide adenine (NADPH) within HeLa cancer cells. This activation can be further promoted (enhanced) by Ir(III)-complex (i.e. [(η5-C5Me5)Ir(phen)(H2O)]2+). The activation of NADPH with simultaneous monitoring of this process can exploit unique chemical reactions within cells. This concept stands in contrast to the conventional, widely recognized concept of biorthogonal chemistry. We have coined the term “bioparallel chemistry” to differentiate this approach.
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