Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications
| Project/Area Number |
22KF0385
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| Project/Area Number (Other) |
22F21764 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 外国 |
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| Review Section |
Basic Section 32020:Functional solid state chemistry-related
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Labuta Jan 国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 主任研究員 (00720690)
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| Co-Investigator(Kenkyū-buntansha) |
VELYCHKIVSKA NADIIA 国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 外国人特別研究員
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| Project Period (FY) |
2023-03-08 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2023: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2022: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Polymers / Porphyrins / Phase separation / Sensing / Energy storage / Porosity |
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| Outline of Research at the Start |
This research aims to design and synthesize stimuli-responsive porphyrin-polymer conjugates. These conjugates comprise a hydrophilic biocompatible polymer with a photoactive porphyrin unit. The physicochemical properties of these molecules will be studied. In particular, the possibility of their use as photodynamic therapy (PDT) agents (i.e. singlet oxygen generators for cancer treatment). These molecules with a dual porphyrin-polymer nature are expected to be useful for various sensing (pH, anion, impurity) or imaging (MRI) applications.
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| Outline of Annual Research Achievements |
The purpose of this project is the design/synthesis and physicochemical characterization of photostable stimuli-responsive porphyrin-polymer conjugates based on the connection of hydrophilic biocompatible/biodegradable polymer with photoactive porphyrin unit. In FY2022, synthetic methods were established. Various porphyrin conjugates with biocompatible polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. Basic characterization using NMR, UV-Vis, FTIR, DSC, SEM and TEM were performed. Detailed investigation of phase-separation properties of porphyrin-PNIPAM conjugates was undertaken. The system exhibits different structures below phase separation temperature ca. 32°C (i.e. 1D supramolecular polymer) and above (i.e. large globular structures). These structures are further tunable by pH.
Also, highly porous functional materials (with surface area >3000 m2/g) were prepared by thermal treatment of suitable polymers.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The research plan is in progress as scheduled.
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| Strategy for Future Research Activity |
Further, the properties of obtained porphyrin-polymer conjugates will be investigated for their response to various external stimuli (pH, temperature, etc.). The thermodynamic model of their phase-separation behaviour will be developed.
The porous functional materials obtained by thermal treatment of suitable polymers will be tested for catalytic, adsorption, sensing and energy storage applications.
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Report
(1 results)
Research Products
(5 results)
