| Project/Area Number |
22KF0402
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| Project/Area Number (Other) |
22F22077 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 外国 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Co-Investigator(Kenkyū-buntansha) |
HE HONGSHEN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 外国人特別研究員
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| Project Period (FY) |
2023-03-08 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2023: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2022: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | hippocampus / CA2 / electrophysiology / SWR / behavioral state / consolidation / medial septum / spatial memory / locomotion / connectome |
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| Outline of Research at the Start |
Spatial navigation critically relies on the hippocampus, a structure that functionally integrates the rate and temporal information that constitutes memory engrams. While much of the circuitry is well characterized, the role of input form the cortex to the small CA2 region remains unknown; my experiment will address the contribution of these projections to memory.
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| Outline of Annual Research Achievements |
We found that CA2 can differentially impact hippocampal network dynamics across behavioral state. During ripples silencing CA2 reduces network synchronization and weakens cross-frequency coupling and memory replay in CA1. During locomotion CA2 inhibition leads to a slower emergence of place fields and poorer lap-by-lap stability ,while during pausing periods, inhibition rsulted in reduced excitability of CA1 pyramidal cells. A novel convolutional neural network model confirmed our results on the population level, suggesting a functional role of CA2 in organizing and differentiating hippocampal network dynamics under distinct behavioral states. These results provide an overall viewpoint for novel functional roles of CA2, not only in organizing SWRs during quiet rest but also impacting learning-associated plasticity during locomotion and supporting spatial coding during awake immobility. These results have been summarized and published in Hippocampus (He et al., 2023).
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