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Intergenerational social mobility and brain cognitive degeneration.

Research Project

Project/Area Number 22KJ0276
Project/Area Number (Other) 22J14503 (2022)
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeMulti-year Fund (2023)
Single-year Grants (2022)
Section国内
Review Section Basic Section 08020:Social welfare-related
Research InstitutionTohoku University

Principal Investigator

LIU YINGXU  東北大学, 医学系研究科, 特別研究員(DC2)

Project Period (FY) 2023-03-08 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2022: ¥500,000 (Direct Cost: ¥500,000)
KeywordsAlzheimer's disease / Social disadvantage / Brain vulnerability / Social class / SES
Outline of Research at the Start

Since individual's social class, as well as cognitive function, is not static; as mobility in the social class brings/damages access to useful health resources (insurance, health check), it will generate growing/downcast influence on one’s cognitive ability. To capture the bidirectional dynamic association, the current project utilized longitudinal data in the UK and followed mobility in social class with the relationship on brain structure features and cognitive trajectories over 20 years.

Outline of Annual Research Achievements

In the current year, I have successfully completed the project that examining relationship between social status and brain cognitive function. The project involved with data integration on sociodemographic, neuropsychologic and T1W1 images in an open dataset from dementia platform of UK (https://www.dementiasplatform.uk/). The results were published at the Alzheimer's Association International Conference (AAIC), the largest international conference in the field of Alzheimer's disease, and notably selected as lighting presentation. In addition, I finished the collaborative research project with Umea University (Sweden, founded by MIRAI 2.0 Joint Seed). The main results were published in the Annual Meeting of the Gerontology Society of America (DOI: 10.1093/geroni/igac059.2909). This study showed a similar parameter in both countries that lifestyle-disease conditions (diabetes, hypertension, depression, and obesity) explained the relationship between SES and the volume of various limbic lobe regions. Such findings suggest targeting disease management from a professional level (i.e., free medical lectures held by the local community, and easy access to hospitals) is the most actionable and effective strategy for maintaining old adults' cognitive well-being, especially for females facing SES disadvantage.

Report

(2 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • Research Products

    (12 results)

All 2024 2023 2022 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Michigan State University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Umea University/Copenhagen University(スウェーデン)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Women at Risk: A Comparative Study on Socioeconomic Status, Lifestyle, Brain, and Cognition Among Older Females in Japan and Sweden2024

    • Author(s)
      Liu Yingxu、Tatewaki Yasuko、Boraxbekk Carl-johan、Thyreau Benjamin、Cui Yuehua、Zhang Ye、Hidaka Yosuke、Kajitani Naoto、Yuki Seiji、Takebayashi Minoru、Ninomiya Toshiharu、Taki Yasuyuki、Karalija Nina
    • Journal Title

      Research Square

      Volume: - Pages: 807-807

    • DOI

      10.21203/rs.3.rs-3833392/v1

    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Intergenerational Social Mobility, Brain Structure, and Cognitive Trajectory: Findings from the Whitehall II Study2023

    • Author(s)
      Liu Yingxu、Liu Yinghao、Cui Yuehua、Thyreau Benjamin、Zhang Ye、Taki Yasuyuki、Chen Honglei、Dementias Platform UK (DPUK) Data Portal
    • Journal Title

      Alzheimer's Dementia

      Volume: 19 Issue: S22 Pages: 78-78

    • DOI

      10.1002/alz.071978

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease2023

    • Author(s)
      Zhang Ye、Tatewaki Yasuko、Nakase Taizen、Liu Yingxu、Tomita Naoki、Thyreau Benjamin、Zheng Haixia、Muranaka Michiho、Takano Yumi、Nagasaka Tatsuo、Taki Yasuyuki
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 15 Pages: 1227325-1227325

    • DOI

      10.3389/fnagi.2023.1227325

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis From 8,695 Old Adults2022

    • Author(s)
      12)Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y, Shibata M,,, Niimura H, ,,, Kubo M, Kiyohara Y
    • Journal Title

      The Journals of Gerontology: Series A

      Volume: 77 Issue: 9 Pages: 1789-1797

    • DOI

      10.1093/gerona/glac093

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease2022

    • Author(s)
      Zhang Ye、Tatewaki Yasuko、Liu Yingxu、Tomita Naoki、Nagasaka Tatsuo、Muranaka Michiho、Yamamoto Shuzo、Takano Yumi、Nakase Taizen、Mutoh Tatsushi、Taki Yasuyuki
    • Journal Title

      GeroScience

      Volume: 44 Issue: 3 Pages: 1563-1574

    • DOI

      10.1007/s11357-022-00584-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does anime, idol culture bring depression? Structural analysis and deep learning on subcultural identity and various psychological outcomes2022

    • Author(s)
      Liu Yinghao、Liu Yingxu、Wen Jiahao
    • Journal Title

      Heliyon

      Volume: 8 Issue: 9 Pages: e10567-e10567

    • DOI

      10.1016/j.heliyon.2022.e10567

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] WOMEN AT RISK: SOCIOECONOMIC STATUS, LIFESTYLE FACTORS, AND BRAIN VULNERABILITY AMONG JAPANESE AND SWEDISH FEMALE2022

    • Author(s)
      Liu Yingxu、Tatewaki Yasuko、Thyreau Benjamin、Liu Yinghao、Zhang Ye、Karalija Nina、Boraxbekk Carl-johan、Taki Yasuyuki
    • Journal Title

      Innovation in Aging

      Volume: 6 Issue: Supplement_1 Pages: 807-807

    • DOI

      10.1093/geroni/igac059.2909

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Intergenerational Social Mobility, Brain Structure, and Cognitive Trajectory: Findings from the Whitehall II Study.2023

    • Author(s)
      Yingxu Liu
    • Organizer
      Alzheimer’s Association International Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] WOMEN AT RISK: SOCIOECONOMIC STATUS, LIFESTYLE FACTORS, AND BRAIN VULNERABILITY AMONG JAPANESE AND SWEDISH FEMALE.2022

    • Author(s)
      Yingxu Liu
    • Organizer
      The Annual Meeting of the Gerontology Society of America
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Funded Workshop] MIRAI 2.0 Connecting Sweden and Japanese Universities2022

    • Related Report
      2022 Annual Research Report

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Published: 2022-04-28   Modified: 2024-12-25  

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