| Project/Area Number |
22KJ0276
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| Project/Area Number (Other) |
22J14503 (2022)
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund (2023)
Single-year Grants (2022) |
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| Section | 国内 |
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| Review Section |
Basic Section 08020:Social welfare-related
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| Research Institution | Tohoku University |
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Principal Investigator |
LIU YINGXU 東北大学, 医学系研究科, 特別研究員(DC2)
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| Project Period (FY) |
2023-03-08 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2022: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | Alzheimer's disease / Social disadvantage / Brain vulnerability / Social class / SES |
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| Outline of Research at the Start |
Since individual's social class, as well as cognitive function, is not static; as mobility in the social class brings/damages access to useful health resources (insurance, health check), it will generate growing/downcast influence on one’s cognitive ability. To capture the bidirectional dynamic association, the current project utilized longitudinal data in the UK and followed mobility in social class with the relationship on brain structure features and cognitive trajectories over 20 years.
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| Outline of Annual Research Achievements |
In the current year, I have successfully completed the project that examining relationship between social status and brain cognitive function. The project involved with data integration on sociodemographic, neuropsychologic and T1W1 images in an open dataset from dementia platform of UK (https://www.dementiasplatform.uk/). The results were published at the Alzheimer's Association International Conference (AAIC), the largest international conference in the field of Alzheimer's disease, and notably selected as lighting presentation. In addition, I finished the collaborative research project with Umea University (Sweden, founded by MIRAI 2.0 Joint Seed). The main results were published in the Annual Meeting of the Gerontology Society of America (DOI: 10.1093/geroni/igac059.2909). This study showed a similar parameter in both countries that lifestyle-disease conditions (diabetes, hypertension, depression, and obesity) explained the relationship between SES and the volume of various limbic lobe regions. Such findings suggest targeting disease management from a professional level (i.e., free medical lectures held by the local community, and easy access to hospitals) is the most actionable and effective strategy for maintaining old adults' cognitive well-being, especially for females facing SES disadvantage.
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