Molecular epidemiology, antiviral resistant variants and therapeutic options of hepatitis B and C in Nigeria
Project/Area Number |
22KK0147
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Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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Research Institution | Nagasaki University |
Principal Investigator |
吉田 レイミント 長崎大学, 熱帯医学研究所, 教授 (90432963)
|
Co-Investigator(Kenkyū-buntansha) |
樋泉 道子 長崎大学, 熱帯医学研究所, 准教授 (00778623)
柳原 克紀 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40315239)
森内 浩幸 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90315234)
|
Project Period (FY) |
2022-10-07 – 2025-03-31
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Project Status |
Granted (Fiscal Year 2022)
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Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2024: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2023: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2022: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | Hepatitis B Virus / Hepatitis C Virus / Hepatitis D Virus / incidence / genotype / drug resistant variant / Nigeria / Viral hepatitis / drug resistant / therapeutic |
Outline of Research at the Start |
DNA/RNA will be extracted from HBV and HCV positive serum samples stored at Nigeria CDC. PCR and sequencing will be performed to determine the genotype, drug resistant variants and predict optimal viral hepatitis therapeutic options. A rapid PCR based genotyping assays will be developed.
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Outline of Annual Research Achievements |
Necessary ethical approvals and Material Transfer Agreement have been obtained to conduct the study. A Nigeria PhD student, studying under the principal investigator at Nagasaki University visited Nigeria CDC to conduct the DNA extraction from 251 Hepatitis B positive samples and transported to Nagasaki University. The epidemiological information database of the viral hepatitis positive subjects has been obtained from Nigeria CDC.
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Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The necessary ethical approvals and MTA have been completed. The epidemiological data of the viral hepatitis survey and the first batch of HBV positive samples have been obtained. The data analysis and sample testing processes are progressing well as planed.
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Strategy for Future Research Activity |
2023 plan: The Japan research team plans to visit Nigeria CDC this year to discuss the ongoing data analysis and sample testing plan with the Nigeria CDC counterparts. Nucleic acid extraction of Hepatitis B Virus and Hepatitis C Virus samples will will be done. The samples will be transported to Nagasaki University for genotyping, drug resistant variant testing and whole genome sequencing analyses.
2024 plan: Further sample testing and data analysis will be done next year. The result of the study will be presented at domestic and international conference.
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Report
(1 results)
Research Products
(1 results)