| Budget Amount *help |
¥529,750,000 (Direct Cost: ¥407,500,000、Indirect Cost: ¥122,250,000)
Fiscal Year 2015: ¥104,000,000 (Direct Cost: ¥80,000,000、Indirect Cost: ¥24,000,000)
Fiscal Year 2014: ¥104,000,000 (Direct Cost: ¥80,000,000、Indirect Cost: ¥24,000,000)
Fiscal Year 2013: ¥107,250,000 (Direct Cost: ¥82,500,000、Indirect Cost: ¥24,750,000)
Fiscal Year 2012: ¥107,250,000 (Direct Cost: ¥82,500,000、Indirect Cost: ¥24,750,000)
Fiscal Year 2011: ¥107,250,000 (Direct Cost: ¥82,500,000、Indirect Cost: ¥24,750,000)
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| Outline of Final Research Achievements |
The intestinal epithelium equips multiple layers of innate defense system and acts as defensive barriers against microbial invaders. Nevertheless, many mucosal pathogenic bacteria can circumvent these defenses and exploit the intestinal epithelium as a replicative niche, a shelter from the host immune surveillance, or a port of entry for dissemination into deeper tissues. In this project, we have concentrated our efforts to (1) Elucidate how Shigella modulate host innate immune response and define the bacterial and host targeting factors, (2) Construct mice intestinal infection model of Shigella, (3) Isolate small compounds that inhabit Shigella effectors.
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