|Budget Amount *help
¥550,420,000 (Direct Cost: ¥423,400,000、Indirect Cost: ¥127,020,000)
Fiscal Year 2015: ¥84,370,000 (Direct Cost: ¥64,900,000、Indirect Cost: ¥19,470,000)
Fiscal Year 2014: ¥102,570,000 (Direct Cost: ¥78,900,000、Indirect Cost: ¥23,670,000)
Fiscal Year 2013: ¥110,890,000 (Direct Cost: ¥85,300,000、Indirect Cost: ¥25,590,000)
Fiscal Year 2012: ¥128,310,000 (Direct Cost: ¥98,700,000、Indirect Cost: ¥29,610,000)
Fiscal Year 2011: ¥124,280,000 (Direct Cost: ¥95,600,000、Indirect Cost: ¥28,680,000)
|Outline of Final Research Achievements
Using molecular biology techniques, we clarified the intracellular localization of the 18 core Atg proteins, as well as the mechanistic basis of PAS formation. We also employed the heat-tolerant yeast K. marxianus in rapidly progressing structural studies of the Atg proteins.
As part of our physiological analysis of autophagy, we identified novel receptor proteins that facilitate selective forms of autophagy, and identified the phosphorylation events and upstream kinases that regulate this process. In addition, we demonstrated the bulk turnover of RNA by autophagy and uncovered its underlying mechanism.