| Budget Amount *help |
¥214,500,000 (Direct Cost: ¥165,000,000、Indirect Cost: ¥49,500,000)
Fiscal Year 2015: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2014: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2013: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
Fiscal Year 2012: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2011: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
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| Outline of Final Research Achievements |
To elucidate the roles of functional molecules localized in the organelle in the presynaptic terminal, we examined synaptic transmission of gene-targeted mice lacking the molecules, and found that the mutant mice exhibited impaired presynaptic plasticity of excitatory synaptic transmission. We also examined the roles of presynaptic molecules interacting with the protein complex that regulated neurotransmitter release, and found that they are associated with the regulation of neurotransmitter release and the dynamics of synaptic vesicles in the presynaptic terminal. Furthermore, we found that some of the protein kinases present in the presynaptic terminal modified presynaptic short-term plasticity.
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