| Project/Area Number |
23220009
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
Inokuchi Kaoru 富山大学, 大学院医学薬学研究部(医学), 教授 (20318827)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKADA Daisuke 北里大学, 医学部, 准教授 (10211806)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHKAWA Noriaki 富山大学, 大学院医学薬学研究部(医学), 講師 (80416651)
SUZUKI Akinobu 富山大学, 大学院医学薬学研究部(医学), 助教 (40424684)
Shehata Mohammad 富山大学, 大学院医学薬学研究部(医学), 助教 (60444197)
SUZUKI Reiko 富山大学, 大学院医学薬学研究部(医学), 特命助教 (50532404)
NISOZONO Hirofumi 富山大学, 研究推進機構研究推進総合支援センター, 助教 (10502289)
|
|---|
| Research Collaborator |
NOMOTO Masanori
YOKOSE Jun
MURAYAMA Emi
ZHAO Qi
KITAMURA Takashi
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥214,110,000 (Direct Cost: ¥164,700,000、Indirect Cost: ¥49,410,000)
Fiscal Year 2015: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2014: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2013: ¥51,220,000 (Direct Cost: ¥39,400,000、Indirect Cost: ¥11,820,000)
Fiscal Year 2012: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2011: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
|
|---|
| Keywords | 記憶アップデート / 神経科学 / セルアセンブリ / 連合記憶 / 光遺伝学 / 海馬 / 扁桃体 / シナプスタグ / 脳･神経 / 記憶形成 / アップデート / 脳・神経 / 記憶 / 記憶の連合 |
|---|
| Outline of Final Research Achievements |
In this study, memory update mechanisms were investigated in cell assembly level. We found that, when two distinct units of information interact to generate a new memory, cellular ensembles corresponding to individual memories overlap. Suppressing the overlap neurons inhibits the association between two memories without affecting the initial memories. In addition, optogenetical co-activation of these ensembles creates an artificial memory. These results indicate that overlap in cellular ensembles plays a critical role in memory association.
|
| Assessment Rating |
Verification Result (Rating)
A
|
Assessment Rating |
Result (Rating)
A: Progress in the research is steadily towards the initial goal. Expected research results are expected.
|
