| Budget Amount *help |
¥214,760,000 (Direct Cost: ¥165,200,000、Indirect Cost: ¥49,560,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
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| Outline of Final Research Achievements |
To elucidate "mammalian-specific epigenetic functions", we addressed two issues. From a viewpoint of mammalian-specific genetics, we analyzed biological functions of LTR retrotransposon-derived genes and demonstrated that Sirh7/Ldoc1 plays an essential role in differentiation and maturation of all types of placental cells, thereby contributing to the regulation of gestation and parturition in mice and also that Sirh11/Zcchc16 plays an important role in cognitive function, such as attention, impulsivity and space memory via regulation of noradrenaline levels in prefrontal cortex. From a viewpoint of mammalian-specific epigenetic, we demonstrated that active DNA demethylation mechanism plays an important role in imprinting memory erasure in primordial germ cells.
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