| Budget Amount *help |
¥215,280,000 (Direct Cost: ¥165,600,000、Indirect Cost: ¥49,680,000)
Fiscal Year 2015: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2014: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2013: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2012: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2011: ¥62,010,000 (Direct Cost: ¥47,700,000、Indirect Cost: ¥14,310,000)
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| Outline of Final Research Achievements |
Modern drugs and agrochemicals are highly functionalized molecules. These molecules are synthesized in multi-steps and frequently without any desired selectivity. For example, polyketide frameworks are prepared in a number of steps and it is almost impossible to prepared only one desired molecule among hundreds of isomers. In this project, we have developed the exceedingly bulky silyl reagent to prepare such polyketides with almost exclusive stereoselectivity. Further, the method was used to prepare biologically active antibiotics as well as sugar derivatives in short steps.
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