| Project/Area Number |
23227003
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | High Energy Accelerator Research Organization |
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Principal Investigator |
Wakatsuki Soichi 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 研究員 (00332114)
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| Co-Investigator(Kenkyū-buntansha) |
後田 裕 大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 教授 (10342601)
三宅 秀樹 大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 研究機関講師 (20403115)
清水 伸隆 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (20450934)
樋口 岳雄 東京大学, カブリ数物連携宇宙研究機構, 准教授 (40353370)
松垣 直宏 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (50342598)
田中 秀治 大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 准教授 (80311124)
原 康二 大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 助教 (90432236)
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| Co-Investigator(Renkei-kenkyūsha) |
KONNO Tomoyuki 高エネ機構, 素粒子原子核研究所, 研究員 (60751518)
KOBAYASHI Aine 高エネ機構, 素粒子原子核研究所, 研究員 (50794749)
PULVERMACHER Christian 高エネ機構, 素粒子原子核研究所, 研究員 (10788087)
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| Research Collaborator |
Kiesling Christian
Andricek Ladislav
Koffmane Christian
Ninkovic Jelena
Moser Hans-Günther
Muller Felix B.
Konorov Igor
Rummel Stefan
Ritter Martin
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥209,820,000 (Direct Cost: ¥161,400,000、Indirect Cost: ¥48,420,000)
Fiscal Year 2015: ¥80,600,000 (Direct Cost: ¥62,000,000、Indirect Cost: ¥18,600,000)
Fiscal Year 2014: ¥79,560,000 (Direct Cost: ¥61,200,000、Indirect Cost: ¥18,360,000)
Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2012: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | ピクセル検出器 / タンパク質結晶構造解析 / タンパク質溶液散乱 / DEPFET検出器 / 構造生物学 / X線結晶構造解析 / X線溶液散乱 / X線結晶解析 |
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| Outline of Final Research Achievements |
We have developed a high-resolution and high-speed readout detector for protein structural analysis, based on the latest pixel detector DEPFET (DEpleted P-channel Field Effect Transistor) developed for particle physics. Evaluation experiments using synchrotron radiation X-rays showed that diffraction images from protein crystals or solutions can be taken with better positional accuracy with DEPFET than existing X-ray detectors, and the hit information can be read out in high frame rate. By arranging sensor modules side by side to constitute a megapixel class large area detector, it is expected to be applied to microcrystal structure analysis of highly difficult proteins or time-resolved solution scattering, and to lead opening up new measurement and analysis techniques.
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| Assessment Rating |
Verification Result (Rating)
A-
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Assessment Rating |
Result (Rating)
A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.
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