| Budget Amount *help |
¥214,500,000 (Direct Cost: ¥165,000,000、Indirect Cost: ¥49,500,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2013: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2012: ¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2011: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
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| Outline of Final Research Achievements |
Fatty acids in membrane phospholipids of mammalian cells and tissues exhibit considerable structural diversity. However, cell biological functions of fatty acyl chains in biological membranes have remained poorly understood. We have recently identified a group of enzymes that regulate fatty acid composition in membrane phospholipids. Based on the findings, we developed methods for manipulating fatty acid composition in membrane phospholipids to explore cell biological functions of fatty acyl chains in biological membranes. We found that specific phospholipid molecular species was required for endocytosis, cell adhesion, and mitochondrial fusion. We also identified proteins whose activity, stability or localization was affected by changes in fatty acid composition in membrane phospholipids. Moreover we found that molecular mechanisms that maintain fatty acid composition in membrane and that an aberrant fatty acid composition in membrane caused inflammatory response and steatosis.
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