| Project/Area Number |
23227005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kobe University |
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Principal Investigator |
Takenawa Tadaomi 神戸大学, バイオシグナル研究センター, 講師 (40101315)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Toshiki 神戸大学, バイオシグナル研究センター, 教授 (30313092)
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| Co-Investigator(Renkei-kenkyūsha) |
IJUIN Takeshi 神戸大学, 大学院医学研究科, 助教 (00361626)
TSUJITA Kazuya 神戸大学, バイオシグナル研究センター, 講師 (10457054)
TOKUDA Emi 神戸大学, 大学院医学研究科, 特任助教 (70621960)
HASEGAWA Junya 大阪大学, 大学院生命機能研究科, 助教 (00533788)
IRINO Yasuhiro 神戸大学, 大学院医学研究科, 特任助教 (10415565)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥201,370,000 (Direct Cost: ¥154,900,000、Indirect Cost: ¥46,470,000)
Fiscal Year 2015: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2014: ¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2013: ¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2012: ¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2011: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
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| Keywords | ホスホイノシタイド / 膜の形 / インスリンシグナル / がん細胞転移 / 膜形成 / 脂質結合タンパク質 / ホスホイノシタイド ５－ホスファターゼ / インスリン / SKIP / Sac1 / PI4P / インスリン シグナル / 膜変形 / PIP3 ホスファターゼ / 脂質結合蛋白質 / F-Barドメイン |
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| Outline of Final Research Achievements |
Phosphoinositides act as crucial lipids to regulate versatile functions in life. Phosphoinositide-binding proteins, FBP17, PSTPIP2, SH3YL1 and ARAP1 recognize and bind membrane curvature, resulting in membrane deformation, such as coated pits and vesiculation of membrane.
PI(3,4,5)P3 5-phosphatase SKIP binds GRP78 in endoplasmic reticulum under resting condition. But in response to insulin, it moves to membranes where it associates with Pak1 and hydrolyses PI(3,4,5)P3 spatio-temporaly around insulin receptors.
Sac1 PI4P 4-phosphatase controls the PI4P concentration in Golgi, which is involved in cell adhesion and tumor metastasis.Thus, decrease in PI4P in Golgi prevents the invasion and metastasis of cancer cells.
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| Assessment Rating |
Verification Result (Rating)
A
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Assessment Rating |
Result (Rating)
A: Progress in the research is steadily towards the initial goal. Expected research results are expected.
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