| Budget Amount *help |
¥216,190,000 (Direct Cost: ¥166,300,000、Indirect Cost: ¥49,890,000)
Fiscal Year 2015: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
Fiscal Year 2014: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2013: ¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2012: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2011: ¥82,680,000 (Direct Cost: ¥63,600,000、Indirect Cost: ¥19,080,000)
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS), which is produced in mitochondria, induces age-related changes in cell and tissue homeostasis. In the present researches, we analyzed the molecular basis of oxidative-stress regulation, which is one of mitochondrial functions mediated by deacetylase Sirt3, and then revealed downstream targets of Sirt3 and their regulatory mechanisms. In addition, we also revealed a novel mechanism of immunosenescence and that chronic inflammation, which is considered to be a basic pathology of age-related diseases, was facilitated by mitochondrial DNA mutations and aging. The combination of assay systems based on these molecular bases and NMR metabolic profiling was used to identify several food factors that regulate aging signals including Sirt3-dependent antioxidant system and proinflammatory cytokine production.
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