| Budget Amount *help |
¥202,540,000 (Direct Cost: ¥155,800,000、Indirect Cost: ¥46,740,000)
Fiscal Year 2015: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2014: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2013: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2012: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2011: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
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| Outline of Final Research Achievements |
The present study aims to elucidate the molecular mechanisms by which growth factors such as progranulin regulate neurodegeneration by combining physiological studies on the role of growth factors in modulating proliferation, differentiation and cell death of neurons and neuropathological studies on neurodegenerative diseases due to mutations in growth factor genes. The present study revealed that the expression of progranulin is increased by brain injury and stresses, and then progranulin is conveyed to lysosomes thereby decreasing lysosomal biogenesis, neuroinflammation and neuronal damages. In addition, the present study also suggests that lysosomal dysfunction with aging is exacerbated by progranulin deficiency, which leads the accumulation of abnormal protein with a resultant onset of neurodegenerative diseases.
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