| Budget Amount *help |
¥225,810,000 (Direct Cost: ¥173,700,000、Indirect Cost: ¥52,110,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2011: ¥52,520,000 (Direct Cost: ¥40,400,000、Indirect Cost: ¥12,120,000)
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| Outline of Final Research Achievements |
G proteins, which cycle between the two different GTP- and GDP-bound conformations (G cycles), play important roles as a "molecular switch" in many intracellular signaling pathways. In the Grant-in-Aid for Scientific Research (S), we investigated how the G cycles of atypical G proteins are regulated dependent on their modes of actions in intracellular vesicle transport system and found that the novel G proteins containing unique biochemical properties and/or structures are involved in the regulation of endosome dynamics, such as lysosome biogenesis, endocytosis, and exocytosis.
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