| Budget Amount *help |
¥214,760,000 (Direct Cost: ¥165,200,000、Indirect Cost: ¥49,560,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
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| Outline of Final Research Achievements |
Selection of sensory organ precursor (SOP) by cell death occurs in the early stage of neural development in Drosophila. SOP cell number is regulated by non-apoptotic caspase activity. We identified the histone methyltransferase eggless/SETDB1 that can synergistically regulate SOP cell number with caspase, suggesting epigenetic histone modification can regulate the robust control of SOP cell number collaborating with non-apoptotic caspase function. For robust tissue regeneration, we found that imaginal disc injury systemically control the methionine metabolism in fat body. Changes of methionine metabolism in fat body then remotely control the imaginal disc regeneration, suggesting that cell death controls tissue regeneration systemically. In mammalian neural development, we found that apoptosis precisely controlled the size and elimination of FGF8 signaling center, thereby actively regulating signal center activity for establishment of robust patterning of brain development.
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