Immunological crosstalk between nasal and reproductive mucosal tissue

• Project/Area Number: 23229004
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The University of Tokyo
• Principal Investigator: Kiyono Hiroshi 東京大学, 医科学研究所, 教授 (10271032)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥214,760,000 (Direct Cost: ¥165,200,000、Indirect Cost: ¥49,560,000); Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2011: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
• Keywords: 粘膜免疫 / 経鼻ワクチン / HSV2 / アジュバント / 生殖免疫 / 性感染症 / ワクチン / ケモカイン / 細胞遊走 / 経鼻免疫 / 膣粘膜感染症 / 膣粘膜指向性関連分子 / エフェクターT細胞

Outline of Final Research Achievements

The antigen administration to the nasal mucosa induces not only the immune responses in the nasal mucosa but reproductive tissue even its distant parts in our body. Therefore, the elucidation of molecular and cellular mechanisms of the nasal-reproductive mucosal crosstalk would be connected for the development of next generation mucosal vaccine for sexually transmitted diseases caused by HIV and HSV. In this project, we aim to identify the responsible molecule for the crosstalk and finally and successfully identified the contribution of unique chemoattractant pathways. In addition, we confirmed the safety of the nasal vaccine with our novel mucosal vaccine developed by nanoparticles and found no dissemination of antigen to the brain in mice and monkey study and found its safety.
These results collectively indicated the successful establishment of basic approval methods for the mucosal vaccine targeting immunological crosstalk between nasal and reproductive mucosal tissue.

Assessment Rating

Verification Result (Rating)

B

Result (Rating)

A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Research Products

• [Journal Article] Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response (2017)
  • Author(s): Joo,S., Fukuyama, Y., Park,E-J., Yuki, Y., Kurashima, Y., Ziegler, S.F. and Kiyono,H.
  • Journal Title: Mucosal Immunology Volume: - Pages: 901-911
  • DOI: 10.1038/mi.2016.103
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Critical role of interleukin-4 modulating regulatory T cells for desensitization, tolerance and inflammation of food allergy. (2017)
  • Author(s): Nakajima-Adachi, H., Shibahara, K., Fujimura, Y., Takeyama, J., Hiraide, E., Kikuchi, A., Murakami, H., Hosono, A., Nochi, T., Wakatsuki, Y., Shimojo, N., Kaminogawa, S., Sato, R., Kiyono, H. and Hachimura, S.
  • Journal Title: PLoS ONE Volume: 12
  • DOI: 10.1371/journal.pone.0172795
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Seed Metabolome analysis of a transgenic rice line expressing cholera toxin B-subunit. (2017)
  • Author(s): Ogawa, T., Kashima, K., Yuki, Y., Mejima, M., Kurokawa, S., Okazawa, A., Kiyono, H. and Ohta, D.
  • Journal Title: Science Reports Volume: -
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. (2017)
  • Author(s): Kunisawa, J., Yagi, K., Ikegami, K., Hamazaki, Y., Suzuki, H., Nagatake, T., Kiyono, H., Kondoh, M., Nasu, A. and Setou, M.
  • Journal Title: Journal of Controlled Release Volume: -
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Allograft inflammatory factor 1 is a regulator of transcytosis in M cells (2017)
  • Author(s): Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H.
  • Journal Title: Nat Commun Volume: 8 Pages: 14509-14509
  • DOI: 10.1038/ncomms14509
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The spleen is the site where mast cells are induced in the development of food allergy. (2017)
  • Author(s): Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, H. and Abe, R.
  • Journal Title: International Immunology Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nanogel-based nasal ghrelin vaccine prevents obesity. (2017)
  • Author(s): Azegami, T., Yuki, Y., Sawada, S,, Mejima, M., Ishige, K., Akiyoshi, K., Itoh, H. and Kiyono H.
  • Journal Title: Mucosal Immunology Volume: -
  • DOI: 10.1038/mi.2016.137
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. (2017)
  • Author(s): Furuta, Y., Tsai, S-H., Kinoshita, M., Fujimoto, K., Okumura, R., Umemoto, E., Kurashima, Y, Kiyono, H., Kayama, H., Takeda, K.
  • Journal Title: PLoS One Volume: 12
  • DOI: 10.1371/journal.pone.0172509
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunology and Cell Biolog. (2017)
  • Author(s): Nelson, S., Kiyono, H. and Kurashima, Y.
  • Journal Title: Immunology & Cell Biology Volume: 95 Pages: 117-8
  • DOI: 10.1038/icb.2016.106
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MicroRNA-mediated dynamic control of mucosal immunity. (2017)
  • Author(s): Park, EJ., Shimaoka, M. and Kiyono, H.
  • Journal Title: Int Immunol Volume: - Pages: 157-163
  • DOI: 10.1093/intimm/dxx019
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. (2017)
  • Author(s): Kurashima, Y. and Kiyono, H.
  • Journal Title: Annual Review of Immunology Volume: - Pages: 51116-52424
  • DOI: 10.1146/annurev-immunol-051116-052424
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. (2016)
  • Author(s): Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H.
  • Journal Title: Regul Toxicol Pharmacol. Volume: 76 Pages: 128-136
  • DOI: 10.1016/j.yrtph.2016.01.023
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ISH NIA OS-02 attenuation of hypertension by less-invasive intranasal vaccination against angiotensin II type 1 receptor in spontaneously hypertensive rats. (2016)
  • Author(s): Azegami, T., Yuki, Y., Hayashi, K., Nakamura, M., Hishikawa, A., Kiyono, H. and Itoh, H.
  • Journal Title: Journal of Hypertension Volume: 1 Pages: 42-42
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epithelial glycosylation in gut homeostasis and inflammation (2016)
  • Author(s): Goto, Y., Uematsu, S. and Kiyono, H.
  • Journal Title: Nat Immunol. Volume: 17 Pages: 1244-1251
  • DOI: 10.1038/ni.3587
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. (2016)
  • Author(s): Lee, J., Park, E.J. and Kiyono H.
  • Journal Title: BMB Reports Volume: 49 Pages: 263-9
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mucosal immunosenescence in the gastrointestinal tract: A mini-review. (2015)
  • Author(s): Sato, S., Kiyono, H. and Fujihashi, K.
  • Journal Title: Gerontology Volume: -
  • DOI: 10.1159/000368897
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Loss of Lymph Node Fibroblastic Reticular Cells and High Endothelial Cells Is Associated with Humoral Immunodeficiency in Mouse Graft-versus-Host Disease. (2015)
  • Author(s): Suenaga, F., Ueha, S., Abe, J., Kosugi-Kanaya, M., Wang, Y., Yokoyama, A., Shono, Y., Shand, F. H., Morishita, Y., Kunisawa, J., Sato, S., Kiyono, H. and Matsushima, K.
  • Journal Title: J Immunol. Volume: 194(1) Pages: 398-406
  • DOI: 10.4049/jimmunol.1401022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells. (2015)
  • Author(s): Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
  • Journal Title: Immunity Volume: 42(2) Pages: 279-293
  • DOI: 10.1016/j.immuni.2015.01.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of selection marker-free rice-based oral cholera toxin B-subunit vaccine and characterization of location and structure of transgene by using whole genome resequencing analysis. (2015)
  • Author(s): Mejima, M., Kashima, K., Kuroda, M., Takeyama, N., Kurokawa S., Fukuyama Y., Kiyono H., Itoh, K., Mitsui, T., and Yuki, Y.
  • Journal Title: Plant Cell Tiss. Org. Cult. Volume: 120 Pages: 35-48
  • DOI: 10.1007/s11240-014-0575-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumonia in macaques. (2015)
  • Author(s): Fukuyama, Y., Yuki, Y., Katakai, Y., Harada, N., Takahashi, H., Takeda, S., Mejima, M., Joo, S., Kurokawa, S., Sawada, S., Shibata, H., Park, EJ., Fujihashi., K, Briles, D., Yasutomi, Y., Tsukada, H., Akiyoshi, K., Kiyono, H.
  • Journal Title: Mucosal Immunology Volume: -
  • DOI: 10.1038/mi.2015.5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Novel Transgenic Rice-based Vaccine: (2015)
  • Author(s): Azegami, T., Itoh, H., Kiyono, H. and Yuki, Y.
  • Journal Title: Arch. Immunol. Ther. Ex Volume: 63(2) Pages: 87-99
  • DOI: 10.1007/s00005-014-0303-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparative whole-genome analyses of selection marker–free rice-based cholera toxin B-subunit vaccine lines with wild-type lines. (2015)
  • Author(s): Kashima, K., Mejima, M., Kurokawa, S., Kuroda, M., Kiyono, H. and Yuki, Y.
  • Journal Title: BMCGgenomics Volume: 48 Pages: 48-48
  • DOI: 10.1186/s12864-015-1285-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vitamins mediate immunological homeostasis and diseases at the surface of the body. (2015)
  • Author(s): Kunisawa J. and Kiyono H.
  • Journal Title: Endocr. Metab. Immune Disord. Drug Targets Volume: 15(1) Pages: 25-30
  • DOI: 10.2174/1871530314666141021114651
  • Peer Reviewed
• [Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα (2015)
  • Author(s): Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
  • Journal Title: International immunology Volume: - Pages: 307-314
  • DOI: 10.1093/intimm/dxv004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] レチノイン酸代謝による皮膚バリアの恒常性維持－線維芽細胞によるマスト細胞調節機構－ (2015)
  • Author(s): 佐藤健、倉島洋介、國澤純、清野宏
  • Journal Title: 臨床免疫・アレルギー科 Volume: 63(2) Pages: 139-145
• [Journal Article] 腸管バリアとしての糖鎖修飾とその制御 (2015)
  • Author(s): 後藤義幸、清野宏
  • Journal Title: 実験医学 Volume: 33(4) Pages: 544-549
• [Journal Article] Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. (2014)
  • Author(s): Sato, A., Suwanto, A., Okabe, M., Sato, S., Nochi, T., Imai, T., Koyanagi, N., Kunisawa, J., Kawaguchi, Y. and Kiyono, H.
  • Journal Title: J. Virol. Volume: 88(23) Pages: 13699-13708
  • DOI: 10.1128/jvi.02279-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. (2014)
  • Author(s): Fujihashi, K., Sato S., and Kiyono, H.
  • Journal Title: Experimental Gerontology Volume: 54 Pages: 21-26
  • DOI: 10.1016/j.exger.2014.01.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Innate lymphoid cells regulate intestinal epithelial cell glycosylation. (2014)
  • Author(s): Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., Setoyama, H., Imaoka, A., Uematsu, S., Akira, S., Domino, S., Kulig, P., Becher, B., Renauld, J-C., Sasakawa, C., Umesaki, Y., Benno, Y. and Kiyono, H.
  • Journal Title: Science Volume: 345(6202) Pages: 1254009-1254009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Skin-barrier homeostasis through Cyp26b1-mediated inhibition of ATP-dependent mast-cell activation by fibroblasts (2014)
  • Author(s): Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
  • Journal Title: Immunity Volume: 40 Pages: 530-41
  • DOI: 10.1016/j.immuni.2014.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Challenge in mucosal vaccines for the control of infectious diseases. (2014)
  • Author(s): Azegami, T., Yuki, Y., and Kiyono, H.
  • Journal Title: Int. Immunol. Volume: 26 Pages: 517-528
  • DOI: 10.1093/intimm/dxu063
  • Peer Reviewed / Open Access
• [Journal Article] The mucosal immune system for vaccine development. (2014)
  • Author(s): Lamichhane, A., Azegami, T. and Kiyono, H.
  • Journal Title: Vaccine Volume: 32(49) Pages: 6711-6723
  • DOI: 10.1016/j.vaccine.2014.08.089
  • Peer Reviewed / Open Access
• [Journal Article] New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. (2014)
  • Author(s): Kurashima Y, Kiyono H.
  • Journal Title: Exp. Mol. Med. Volume: 46
  • DOI: 10.1038/emm.2014.7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Runx2-I Isoform Contributes to Fetal Bone Formation Even in the Absence of Specific N-Terminal Amino Acids. (2014)
  • Author(s): Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S.
  • Journal Title: PLoS One Volume: 9 Pages: 108294-108294
  • DOI: 10.1371/journal.pone.0108294
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine (2014)
  • Author(s): Tokuhara, D., Nochi, T., Matsumura, A., Mejima, M., Takahashi, Y., Kurokawa, S., Kiyono, H. and Yuki Y.
  • Journal Title: Dig Dis Sci. Volume: 59 Pages: 2682-2692
  • DOI: 10.1007/s10620-014-3203-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism (2014)
  • Author(s): Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H.
  • Journal Title: J Immunol Volume: 193 Pages: 1666-1671
  • DOI: 10.4049/jimmunol.1302944
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice (2014)
  • Author(s): Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
  • Journal Title: Inflammatory Bowel Diseases Volume: 5 Pages: 790-799
  • DOI: 10.1097/mib.0000000000000017
  • Peer Reviewed / Open Access
• [Journal Article] Generation of colonic IgA-secreting cells in the caecal patch. (2014)
  • Author(s): Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
  • Journal Title: Nature Comm. Volume: 5 Pages: 1-13
  • DOI: 10.1038/ncomms4704
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A rice-based soluble form of a murine TNF -specific llama variable domain of heavy-chain antibody suppresses collagen -induced arthritis in mice. (2014)
  • Author(s): Abe, M., Yuki, Y., Kurokawa, S., Mejima, M., Kuroda, M., Park, E.J., Scheller, J. Nakanishi, U. and Kiyono, H.
  • Journal Title: J. Biotechnol. Volume: 10:175 Pages: 45-52
  • DOI: 10.1016/j.jbiotec.2014.02.005
  • Peer Reviewed / Open Access
• [Journal Article] 粘膜ワクチンを基盤とした次世代ワクチンの開発 (2014)
  • Author(s): 福山賀子、清野宏
  • Journal Title: 最新医学 Volume: 69(4) Pages: 62-69
• [Journal Article] 次世代ワクチン開発への課題と挑戦-経口ワクチン- (2014)
  • Author(s): 鹿島光司、幸義和、清野宏
  • Journal Title: BIO INDUSTRY Volume: 31(6) Pages: 4-10
• [Journal Article] 抑制型免疫システムを応用した次世代型抗アレルギーワクチンの開発 (2014)
  • Author(s): 高里良宏、倉島洋介、清野宏、國澤純
  • Journal Title: BIO INDUSTRY Volume: 31(6) Pages: 55-60
• [Journal Article] 自然リンパ球による腸管上皮細胞の糖鎖修飾誘導・制御システム (2014)
  • Author(s): 後藤義幸、清野宏
  • Journal Title: 分子消化器病 Volume: 11(4) Pages: 86-88
• [Journal Article] 細胞外核酸を介したマスト細胞の活性化と炎症性腸疾患 (2014)
  • Author(s): 倉島洋介、清野宏、國澤純
  • Journal Title: 生化学 Volume: 86(6) Pages: 798-802
• [Journal Article] Change in localization of cholera toxin B-subunit expressed in rice upon RNAi-mediated suppression of endogenous storage proteins leads to down-regulation of the rice allergen protein RAG2. (2014)
  • Author(s): Kurokawa, S., et al.
  • Journal Title: Plant Cell Reports Volume: 33 Pages: 75-87
  • DOI: 10.1007/s00299-013-1513-3
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• [Journal Article] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome (2014)
  • Author(s): Takemura, N., et al.
  • Journal Title: Nature Communications Volume: 5 Pages: 3492-3492
  • DOI: 10.1038/ncomms4492
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• [Journal Article] Transcription factor Spi-B-dependent and -independent pathways for the development ofPeyer's patch M cells. (2013)
  • Author(s): Sato, S., et al.
  • Journal Title: Mucosal Immunol Volume: ６ Pages: 838-846
  • DOI: 10.1038/mi.2012.122
  • Peer Reviewed
• [Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 vell tesponses through regulation of luminal ATP in the small intestine (2013)
  • Author(s): Kusu, T., et al.
  • Journal Title: J Immunol Volume: 190 Pages: 774-783
  • DOI: 10.4049/jimmunol.1103067
  • Peer Reviewed
• [Journal Article] Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. (2013)
  • Author(s): Il Gyu Kong, Ayuko Sato, Yoshikazu Yuki, Tomonori Nochi, Haruko Takahashi, et al.
  • Journal Title: Infection and Immunology Volume: (online) Pages: 1625-1634
  • DOI: 10.1128/iai.00240-13
  • Peer Reviewed
• [Journal Article] Potential Roles of CCR5(+) CCR6(+) Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses. (2013)
  • Author(s): Fukuyama. Y., et al.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0060453
  • Peer Reviewed
• [Journal Article] Microbe-dependent CD11b+ IgA+ plasma cells in early-phase robust intestinal IgA responses in mice (2013)
  • Author(s): J. Kunisawa, M. Gohda, E. Hashimoto, I. Ishikawa, M. Higuchi, Y. Suzuki, Y. Goto, C. Panea, I. I. Ivanov, R. Sumiya, L. Aayam, T. Wake, S. Tajiri, Y. Kurashima, S. Shikata、S. Akira, K. Takeda, H. Kiyono
  • Journal Title: Nat Commun Volume: 10-1038 Pages: 1038-1038
  • DOI: 10.1038/ncomms2718
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. (2013)
  • Author(s): Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
  • Journal Title: Nature Comminications Volume: 4 Pages: 1949-1949
  • DOI: 10.1038/ncomms2949
  • Peer Reviewed
• [Journal Article] Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer's Patches. (2013)
  • Author(s): Obata, T., et al.
  • Journal Title: Journal of Immunology Volume: 191 Pages: 942-8
  • DOI: 10.4049/jimmunol.1200636
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of α-Amylase/trypsin inhibitor-like protein family as major rice allergens. (2013)
  • Author(s): Kurokawa, S., et al.
  • Journal Title: Journal of Proteome Research Volume: 12 Pages: 3372-3382
  • DOI: 10.1021/pr4002146
  • Peer Reviewed
• [Journal Article] Rice-based orally administered antibody fragment prophylaxis and therapy against rotavirus infection. (2013)
  • Author(s): Tokuhara, D., et al.
  • Journal Title: J. Clin. Invest Volume: 123 Pages: 3829-3838
  • DOI: 10.1172/jci70266
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• [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. (2013)
  • Author(s): Imai, T., et al.
  • Journal Title: PLoS One Volume: 8
  • DOI: 10.1371/journal.pone.0072050
  • Peer Reviewed
• [Journal Article] Induction of Toxin-specific Neutralizing Immunity by Molecularly Uniform Rice-based Oral Cholera Toxin B Subunit Vaccine without Plant-associated Sugar Modification (2013)
  • Author(s): Yuki, Y., et al.
  • Journal Title: Plant Biotechnology Journal Volume: 11 Pages: 799-808
  • DOI: 10.1111/pbi.12071
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition (2013)
  • Author(s): Kishino S, Takeuchi M, Park S, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 110 Pages: 17808-17813
  • DOI: 10.1073/pnas.1312937110
  • Peer Reviewed
• [Journal Article] Interleukin 15 and CD4+ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. (2013)
  • Author(s): Korneychuk N., et al.
  • Journal Title: Gastroenterology Volume: 146(4) Pages: 1017-1027
  • DOI: 10.1053/j.gastro.2013.12.023
  • Peer Reviewed
• [Journal Article] Vitamin-mediated regulation of intestinal immunity (2013)
  • Author(s): Kunisawa, J., et al.
  • Journal Title: Front in Immunol Volume: 4 Pages: 189-189
  • DOI: 10.3389/fimmu.2013.00189
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nutritional components regulate the gut immune system and its association with intestinal immune disease development (2013)
  • Author(s): Lamichhane, A., et al.
  • Journal Title: J Gastroenterol Hepatol Volume: 4 Pages: 18-24
  • DOI: 10.1111/jgh.12259
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. (2013)
  • Author(s): Kurashima Y, Goto Y, Kiyono H.
  • Journal Title: Eur. J. Immunol. Volume: 12 Pages: 3108-3115
  • DOI: 10.1002/eji.201343782
  • Peer Reviewed
• [Journal Article] Nanogel-based antigen-delivery system for nasal vaccines. (2013)
  • Author(s): Yuki, Y., et al.
  • Journal Title: Biotechnol. Genet. Eng. Rev. Volume: 29(1) Pages: 61-72
  • DOI: 10.1080/02648725.2013.801226
  • Peer Reviewed
• [Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. (2012)
  • Author(s): Y. Kurashima, T. Amiya, T. Nochi, K. Fujisawa, T. Haraguchi, H. Iba, H. Tsutsui, S. Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono
  • Journal Title: Nat Commun Volume: 3-1034 Pages: 1034-1034
  • DOI: 10.1038/ncomms2023
  • Peer Reviewed
• [Journal Article] Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria (2012)
  • Author(s): G. F. Sonnenberg, L. A. Monticelli, T. Alenghat, T. C. Fung, N. A. Huntnick, J. Kunisawa, N. Shibata, S. Grunberg, Rohini Shinha, A. M. Zahm, M. R. Tardif, T. Sathaliyawala, M. Kubota, D. L. Farber, R. G. Collman, A. Shaked, L. A. Fouser, D. B. Weiner, P. A. Tessier, J. R Friedman, H. Kiyono, F. D. Bushman, K. Mi Chang, and David Artis.
  • Journal Title: Science Volume: 336 Pages: 1321-1325
  • DOI: 10.1126/science.1222551
  • Peer Reviewed
• [Journal Article] Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice (2012)
  • Author(s): Tanaka, S
  • Journal Title: J Immunol Volume: 188 Pages: 6145-55
  • DOI: 10.4049/jimmunol.1103660
  • Peer Reviewed
• [Journal Article] Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. (2012)
  • Author(s): Jeon, Seong Gyu
  • Journal Title: PLoS Pathogens Volume: 8
  • DOI: 10.1371/journal.ppat.1002714
  • Peer Reviewed
• [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon (2012)
  • Author(s): Kinoshita, M.
  • Journal Title: J Immunol Volume: 189 Pages: 2869-2878
  • DOI: 10.4049/jimmunol.1200420
  • Peer Reviewed
• [Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. (2012)
  • Author(s): Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
  • Journal Title: International Immunology Volume: 24 Pages: 613-23
  • DOI: 10.1093/intimm/dxs068
  • Peer Reviewed
• [Journal Article] The mucosal immune system of the respiratory tract (2012)
  • Author(s): Sato, S
  • Journal Title: Curr Opin Virol Volume: 2 Pages: 225-232
  • DOI: 10.1016/j.coviro.2012.03.009
  • Peer Reviewed
• [Journal Article] Alcaligenes is commensal bacteria habituating in the gut-associated lymphoid tissue for the regulation of intestinal IgA responses (2012)
  • Author(s): Kunisawa, J
  • Journal Title: Front in Immunol Volume: 3 Pages: 1-5
  • DOI: 10.3389/fimmu.2012.00065
  • Peer Reviewed
• [Journal Article] Gut-associated lymphoid tissues for the development of oral vaccines. (2012)
  • Author(s): Kunisawa, J
  • Journal Title: Adv Drug Deliv Rev. Volume: 64 Pages: 523-530
  • DOI: 10.1016/j.addr.2011.07.003
  • Peer Reviewed
• [Journal Article] The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome. (2012)
  • Author(s): Egawa, N., et al
  • Journal Title: J. Virol. Volume: 86 Pages: 3276-3281
  • DOI: 10.1128/jvi.06450-11
  • Peer Reviewed
• [Journal Article] A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. (2012)
  • Author(s): Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, Azuma N.
  • Journal Title: PLoS One Volume: 7(1)
  • DOI: 10.1371/journal.pone.0029677
  • Peer Reviewed
• [Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation (2012)
  • Author(s): Takagi, S
  • Journal Title: Blood Volume: 119 Pages: 2768-2777
  • DOI: 10.1182/blood-2011-05-353201
  • Peer Reviewed
• [Journal Article] Novel vaccine development strategies for inducing mucosal immunity. (2012)
  • Author(s): Fukuyama Y
  • Journal Title: Expert Rev Vaccines Volume: 67 Pages: 367-379
  • DOI: 10.1586/erv.11.196
  • Peer Reviewed
• [Journal Article] M cell-targeted mucosal vaccine strategies (2012)
  • Author(s): Yamamoto M
  • Journal Title: Curr Top Microbiol Immunol. Volume: 354 Pages: 39-52
  • DOI: 10.1007/82_2011_134
  • Peer Reviewed
• [Journal Article] Epithelial barrier : an interface for the cross-communication between gut flora and immune system (2012)
  • Author(s): Goto Y
  • Journal Title: Immunol Rev. Volume: 245 Pages: 147-163
  • DOI: 10.1111/j.1600-065x.2011.01078.x
  • Peer Reviewed
• [Journal Article] Immunological function of sphingosine 1-phosphate in the intestine (2012)
  • Author(s): Kunisawa J
  • Journal Title: Nutrients Volume: 4 Pages: 154-166
  • DOI: 10.3390/nu4030154
  • Peer Reviewed
• [Journal Article] The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. (2011)
  • Author(s): Kim DY, et al
  • Journal Title: J. Immunol. Volume: 186(7) Pages: 4253-4262
  • DOI: 10.4049/jimmunol.0903794
  • Peer Reviewed
• [Journal Article] Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. (2011)
  • Author(s): Okada K
  • Journal Title: Adv Othrhinolaryngol. Volume: 72 Pages: 31-36
  • DOI: 10.1159/000324591
  • Peer Reviewed
• [Journal Article] A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens (2011)
  • Author(s): Kawalec M, Reichhart JM, Sasakawa C
  • Journal Title: Cell Host Microbe. Volume: 9 Pages: 376-389
  • DOI: 10.1016/j.chom.2011.04.010
  • Peer Reviewed
• [Journal Article] Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. (2011)
  • Author(s): Burggraf, M.
  • Journal Title: Mol Nutr Food Res Volume: 55 Pages: 1475-1483
  • DOI: 10.1002/mnfr.201000634
  • Peer Reviewed
• [Journal Article] Host pathogens. Editorial overview. (2011)
  • Author(s): Stappenbeck T
  • Journal Title: Curr Opin Immunol. Volume: 23 Pages: 445-447
  • DOI: 10.1016/j.coi.2011.07.017
  • Peer Reviewed
• [Journal Article] M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. (2011)
  • Author(s): Kim SH
  • Journal Title: Eur J Immunol. Volume: 41 Pages: 3219-3229
  • DOI: 10.1002/eji.201141592
  • Peer Reviewed
• [Presentation] 腸管マルチエコシステムによる炎症制御 (2017)
  • Author(s): Kiyono, H.
  • Organizer: The 17th Symposium on Japanese Society for Pediatoric Inflammatory Bowel Disease
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2017-02-05
  • Int'l Joint Research / Invited
• [Presentation] Analysis of miRNA candidates as biomarkers for prediction and evaluation of mucosal vaccination (2017)
  • Author(s): Nakahashi, R.
  • Organizer: The 10th Meeting of the Japanese Vaccine Adjuvant Research Consortium,
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2017-01-24
  • Int'l Joint Research / Invited
• [Presentation] コメ型経口ワクチンMucoRice開発プロジェクト (2017)
  • Author(s): Kiyono H.
  • Organizer: Joint Symposium of The University of Tokyo and Institute of Industrial Science, Activities lead by NY Office,
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2017-01-20
  • Int'l Joint Research / Invited
• [Presentation] ガーナにおける感染症サーベイランス体制強化とコレラ菌・HIVなどの腸管粘膜感染防御に関する研究 (2016)
  • Author(s): Kiyono H.
  • Organizer: Japan Agency for Medical Research and Development’s 革新的医療技術創出拠点project Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-12-19
  • Int'l Joint Research / Invited
• [Presentation] Intenstinal M cells contribute to maintenance of gut immune homeostasis (2016)
  • Author(s): Kiyono H.
  • Organizer: The 45th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-12-05
  • Int'l Joint Research / Invited
• [Presentation] Cutting Edge of Mucosal Immunology and Its Clinical Application (2016)
  • Author(s): Kiyono H.
  • Organizer: International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
  • Place of Presentation: Kuara Lumpur, Malaysia
  • Year and Date: 2016-11-21
  • Int'l Joint Research / Invited
• [Presentation] Regulation of Epithelial Clycosylation by Mucosal Immunity and Gut Microbiota (2016)
  • Author(s): Kiyono H.
  • Organizer: The 23rd General meeting of the Japanese Association for Dental Science
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2016-10-23
  • Int'l Joint Research / Invited
• [Presentation] カチオン化ナノゲルデリバリーシステムを用いた次世代型経鼻ワクチンの開発 (2016)
  • Author(s): Kiyono H.
  • Organizer: The 20th Annual meeting of the Japanese Society for Vaccinology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-10-22
• [Presentation] Epithelial Cells-Innate Lymphoid Cells-Th Cells Trio-regulation for Gut Homeostasis and Inflammation (2016)
  • Author(s): Kiyono H.
  • Organizer: The 4th Annual Meeting of the International Cytokine and Interferon Society
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-10-18
  • Int'l Joint Research / Invited
• [Presentation] Epithlial Cells-Innate Lymphoid Cells-T Cells Trio-regulation for Gut homeostasis and Inflammation (2016)
  • Author(s): Kiyono H.
  • Organizer: International Cytokine & Interferon Society, ICIS Cytokines 2016
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-10-18
  • Int'l Joint Research / Invited
• [Presentation] 粘膜免疫の最新情報と炎症性疾患の制御に向けた経粘膜治療戦略 (2016)
  • Author(s): Kiyono H.
  • Organizer: The 29th Annual Meeting of Japan Society of Stomata-pharyngology
  • Place of Presentation: Matsue-shi, Shimane-ken
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] Uniqueness of Mucosa-associated Lymphoid Tissues for Clinical Application (2016)
  • Author(s): Kiyono H.
  • Organizer: The 40th Annual Meeting of the Japanese Society of Lymphology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-06-25
  • Int'l Joint Research / Invited
• [Presentation] Innate lymphoid cell and T cell synchronously regulate gut epithelial cell fucosylation (2016)
  • Author(s): Kiyono H.
  • Organizer: The 10th International Symposium on Glycosyltransferases
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-06-19
  • Int'l Joint Research / Invited
• [Presentation] MucoRice and NanoGel: New Generation of Mucosal Vaccines for Aero-digestive Infectious Diseases (2016)
  • Author(s): Kiyono H.
  • Organizer: HWASUN International Vaccine Forum
  • Place of Presentation: Hwasun, Korea
  • Year and Date: 2016-06-10
  • Int'l Joint Research / Invited
• [Presentation] Mucosal Multi-ecosystem for the Induction and Regulation of Symbiosis and Protection (2016)
  • Author(s): Kiyono H.
  • Organizer: The 60th Annual General Assembly and Scientific Meeting of the Japan Colleage of Rheumatology.
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-04-23
  • Int'l Joint Research / Invited
• [Presentation] “Mucosal Innate Lymphoid Cells and Mast Cells for the Regulation of Symbiosis and Inflammation” (2015)
  • Author(s): Kiyono, H.
  • Organizer: World Immune Regulation Meeting IX
  • Place of Presentation: Davos, Switzerland.
  • Year and Date: 2015-03-21
  • Invited
• [Presentation] “Innovative Oral Vaccine：MucoRice” (2015)
  • Author(s): Kiyono, H.
  • Organizer: “2015 Seminar for the Quality and Safety Improvements of Dental Practice” Kanagawa Dental Association
  • Place of Presentation: Kanagawa, Japan.
  • Year and Date: 2015-03-08
  • Invited
• [Presentation] “The Mucosal Immune System for Symbiosis and Elimination” (2015)
  • Author(s): Kiyono, H.
  • Organizer: The 34th Shirokane Symposium, The 50th Anniversary of Founding of the Kitasato University School of pharmacy
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2015-02-28
  • Invited
• [Presentation] “Mucosal Immunity: The Adaptation of oral-Digestive Immune System for Vaccine Development” (2015)
  • Author(s): Kiyono, H.
  • Organizer: The 3rd Medical Advisor Workshop, The Academy of Clinical Dentistry
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2015-02-11
  • Invited
• [Presentation] Gut Microflora Influences Pathology in the Kawasaki Disease (KD) VasculitisMouse Model (2015)
  • Author(s): Wakita, D., Kurashima, Y., Takasato, Y., Lee, Y., Shimada, K., Chen, S., Crother, T. R., Fishbein, M. C., Lehman, T.J.A., Kiyono, H., and Arditi , M.
  • Organizer: International Kawasaki Disease Symposium
  • Place of Presentation: Hawaii, USA.
  • Year and Date: 2015-02-03 – 2015-02-06
• [Presentation] “Advancing the Knowledge of Immunology for Disease Treatments.” (2015)
  • Author(s): Kiyono, H.
  • Organizer: Science Council of Japan and The Pharmaceutical Society of Japan Symposium
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2015-01-09
  • Invited
• [Presentation] Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. (2014)
  • Author(s): Goto, Y., Panea, C., Lee, C. and Ivanov, I.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2014-12-12
• [Presentation] E-NPP3 (CD203c) negatively regulates ATP-dependent allergic responses by basophils and mast cells. (2014)
  • Author(s): Tsai, S-H., Kinoshita, M., Kayama, H., Okuma, R., Kiyono, H., Karasuyama, H. and Takeda, K.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Loss of lymph node fibroblastic reticular cells and high endothelial cells underlies humoral immunodeficiency in mouse GVHD. (2014)
  • Author(s): Ueha, S., Suenaga, F., Abe, J., Kosugi, M., Shono, Y., Kunisawa, J., Sato S., Kiyono, H. and Matsushima, K.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Resistance to helminthic infection is dependent on mast cell activation mediated by ATP in Spi-B-deficient mice. (2014)
  • Author(s): Shimokawa, C., Kanaya, T., Ishikawa, K., Kurashima Y., Kiyono, H., Kaisho T. and Ohno, H.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology, Kyoto
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Critical role of TSLP-TSLPR interaction in inducing secretory IgA responses after mucosal immunizations. (2014)
  • Author(s): Joo, S., Fukuyama, Y., Yuki Y., Kurashima, Y., Ziegler, S.F., Park E-J. and Kiyono, H.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Vaginal resident memory T cells induced by intranasal vaccination are critical for early clearance of genital HSV-2 infection. (2014)
  • Author(s): Suwanto, A., Sato A., Sato S., Nochi, T., Kunisawa, J. and Kiyono, H.
  • Organizer: The 43rd Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] “Rice Protein Body and Cationic Nanogel as Antigen Delivery Vehicle for Mucosal Vaccines” (2014)
  • Author(s): Kiyono, H.
  • Organizer: 8th International Symposium on Nanomedicine (ISNM2014)
  • Place of Presentation: Matsuyama, Ehime.
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] “Microbial Molding of Mucosal Immunity” (2014)
  • Author(s): Kiyono, H.
  • Organizer: ACR/ARHP Annual Meeting
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] “Rice-based Oral Vaccine “MucoRice” for the Control of Enteric Diarrheal Disease” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 62nd Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2014-11-10
  • Invited
• [Presentation] “Cross-talk between the Mucosal Immune System and Environmental Factors” (2014)
  • Author(s): Kiyono, H.
  • Organizer: 11th Nestlé International Nutrition Symposium on “Nutrition and the Human Gut Microbiome”
  • Place of Presentation: Lausanne, Switzerland.
  • Year and Date: 2014-10-23
  • Invited
• [Presentation] “Mucosal Innate Immune System and Vaccine Development” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 1st International Symposium on Mucosal Immunity and Vaccine Development 2014.
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-10-21
  • Invited
• [Presentation] “Tissue-specific signals control mast cell function for the maintenance of tissue homeostasis” (2014)
  • Author(s): Kurashima, Y.
  • Organizer: The 1st International Symposium on Mucosal Immunity and Vaccine Development 2014.
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-10-21
  • Invited
• [Presentation] "Mucosal Connections Between Airway and Reproductive Immunity" (2014)
  • Author(s): Kiyono, H.
  • Organizer: 10th Research Symposium on Human Natural Defense System in Conjunction with PRAMS 2014 in Commemoration of the 10th Anniversary of The Airway Mucus Institute
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] Tissue-specific signals control mast cell function for the maintenance of tissue homeostasis (2014)
  • Author(s): Kurashima, Y.
  • Organizer: 2nd Novo Nordisk Innovation Summit 2014
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-10-02
  • Invited
• [Presentation] “Mucosal Links between Innate-epithelial Cells and Commensal Flora for the Development of New Immune-prevention and -therapy” (2014)
  • Author(s): Kiyono, H.
  • Organizer: 2nd Novo Nordisk Innovation Summit 2014
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-10-01
  • Invited
• [Presentation] “Development of Next Generation Vaccine based on Mucosal Immunology~Future of Mucosal Vaccine” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 65th Kanto Region Otorhinolaryngology Allergy Discussion Group
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-09-21
  • Invited
• [Presentation] “Innate Lymphoid Cells Regulate Intestinal Epithelial Cell Fucosylation for Symbiosis and Elimination” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 26th Symposium on Microbial Sciences ~The Symphony of Microbial Science and Medical care~
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] “Trends in Immunological Memory and Vaccine Development”, Organizer and Speaker, “Mucosal Immunity and Vaccine Development” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 2nd Symposium of International Immunological Memory and Vaccine Forum, (IIMVF)
  • Place of Presentation: La Jolla, USA.
  • Year and Date: 2014-08-26
  • Invited
• [Presentation] Whole genome analysis of selection marker-free MucoRice-CTB, a rice-based oral cholera vaccine (2014)
  • Author(s): Kashima, K.
  • Organizer: International Plant Biotechnology Association
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2014-08-10 – 2014-08-15
• [Presentation] “Oral Vaccine, MucoRice Fighting against the Diarrhea” (2014)
  • Author(s): Kiyono, H.
  • Organizer: JSI organized Public Lecture Series Meneki Fushigi Mirai 2014.
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-08-10
  • Invited
• [Presentation] “Reciprocal Cooperation of Intra-tissue Commensal Bacteria, Innate Lymphoid Cells and Mast Cells for the Integrated Mucosal Immunoregulation” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 38th Aso Symposium 2014.
  • Place of Presentation: Kumamoto, Japan.
  • Year and Date: 2014-07-25 – 2014-07-26
  • Invited
• [Presentation] “Development of Mucosal Immunology Driven Rice-based Vaccine “MucoRice” by the Fusion Research of Medical, Agricultural and Engineering Sciences” (2014)
  • Author(s): Kiyono, H.
  • Organizer: The 13th Shikoku Immunology Forum 2014
  • Place of Presentation: Tokushima, Japan.
  • Year and Date: 2014-06-21
  • Invited
• [Presentation] “Mucosal Connections between Microbial Ecology and Immunity for the Homeostasis and Inflammatory Responses” (2014)
  • Author(s): Kiyono, H.
  • Organizer: 7th International Immunonutrition Workshop -Eating for Preventing-
  • Place of Presentation: Carovigno, Italy.
  • Year and Date: 2014-05-01
  • Invited
• [Presentation] ”Fusion of Medical, Plant and Engineering Science Led to the Creation of Rice-based Vaccine, MucoRice” (2014)
  • Author(s): Kiyono, H.
  • Organizer: SKIL Future Forum -Science Leads to Safe Life-
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-04-18
  • Invited
• [Presentation] “Can We Prevent Infectious Diseases by Rice?” (2014)
  • Author(s): Kiyono, H.
  • Organizer: Seminar for Knowledge of Hub, National University Joint Usage-Research Center
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2014-04-18
  • Invited
• [Presentation] The Intestinal Microbiota for Mucosal Decision of Immunity and Tolerance (2013)
  • Author(s): Kiyono, H.
  • Organizer: International Yakult Symposium 2013 on “The Intestinal Microbiota and Probiotics: Exploiting Their Influence on Health”
  • Place of Presentation: London, UK.
  • Invited
• [Presentation] Mucosal Connection for Immunity, Tolerance and Commensal Microbiota (2013)
  • Author(s): Kiyono, H.
  • Organizer: JSPS: France-Japan Joint Forum “Frontiers inInnate Immunity”
  • Place of Presentation: Strasbourg, France.
  • Invited
• [Presentation] Immune Regulation and Monitoring at the Epithelial Surface of the Intestine (2013)
  • Author(s): Kiyono, H.
  • Organizer: Fondation Mérieux: Targeting Commensal Flora to Better Shape Protective Immune Responses for Better Disease Prevention and Therapy
  • Place of Presentation: Annucy, France.
  • Invited
• [Presentation] Immunological Interventions and Vaccine Development for the Elderly (2013)
  • Author(s): Kiyono, H.
  • Organizer: ICI 15th Satellite Symposium “Aging and the Immune System”
  • Place of Presentation: Milan, Italy.
  • Invited
• [Presentation] The Mucosal immune system for New Generation of Prophylaxis and Therapeutic Nasal and Oral vaccines (2013)
  • Author(s): Kiyono, H.
  • Organizer: The 7th International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
  • Place of Presentation: Shimane, Japan.
  • Invited
• [Presentation] MucoRice System for New Generation of Prophylaxis and Therapeutic Oral Vaccine (2013)
  • Author(s): Kiyono, H.
  • Organizer: The 7th Vaccine & ISV Congress
  • Place of Presentation: Barcelona, Spain.
  • Invited
• [Presentation] The Intestinal Immune System for Mucosal Connections of Immunity, Commensal Microbiota and Vaccine (2013)
  • Author(s): Kiyono, H.
  • Organizer: 2013 Joint Meeting of the 13th Aaian Pan-pacific Society for Pediatric Gastroenterology, Hepatology and Nuritutionand the 40th Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Tokyo, Japan.
  • Invited
• [Presentation] Reverse Control of ATP-P2X7-dependent Mast Cells in Mucosa and Skin for Inflammation (2013)
  • Author(s): Kiyono, H.
  • Organizer: Annual Meeting of the French Society for Immunology
  • Place of Presentation: Paris, France.
  • Invited
• [Presentation] Mast Cells and Innate Lymphoid Cells for “Mucosal Barrier and Inflammation (2013)
  • Author(s): Mast Cells and Innate Lymphoid Cells for “Mucosal Barrier and Inflammation
  • Organizer: Germany-Japan Immunology Seminar 2013 -Challenge in Immunology for Opening the Undestanding of Human Immune System and Disease-
  • Place of Presentation: Shizuoka, Japan.
  • Invited
• [Presentation] MucoRice: Rice-based Oral Vaccine Development
  • Author(s): Kiyono, H
  • Organizer: Molecular Immunology & Immunogenetics Congress 2012
  • Place of Presentation: Antalya, Turkey
  • Invited
• [Presentation] Mucosal Innate Immune System for Mutalisum, Inflammation and Elimination
  • Author(s): Kiyono, H
  • Organizer: The 4th Microbial Pathogenesis & Immunity Symposium
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Mucosal Integration of Mutualism and Elimination for Surface barrier System
  • Author(s): Kiyono, H
  • Organizer: International Meeting of the Microbioligical Society of Korea
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Mucosal integrated immunological seesaw between mutualization and elimination in the intestine
  • Author(s): Kiyono, H
  • Organizer: The 19th East Asia Joint Symposium on Biomedical Research "Moleculer Understanding for Physiology and Pathology."
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Mucosal Vaccine for the Control of Infectious Diseases
  • Author(s): Kiyono, H
  • Organizer: STS International Forum 9th Annual Meeting
  • Place of Presentation: 京都、国立京都国際会館
  • Invited
• [Presentation] Spick-and-span in mucosal vaccine development
  • Author(s): Kiyono, H
  • Organizer: The 34th Naito Conference on Infection, Immunity and their Contral for Health: Mucosal Barrier, Pathogen and Vaccine
  • Place of Presentation: 札幌、シャトレーゼ ガトーキングダムサッポロ
  • Invited
• [Presentation] Spick-and-span in Mucosal Immunity: From Intestional Homeostasis to Vaccine Develipment
  • Author(s): Kiyono, H
  • Organizer: A-IMBN Symposium
  • Place of Presentation: Jeju , Korea
  • Invited
• [Presentation] MucoRice: Fusion of Mucosal immunology and plant biology ked to the development of rice-based oral vaccine
  • Author(s): Kiyono, H
  • Organizer: The 10th International Congress on Plant Molecular Biology
  • Place of Presentation: Jeju , Korea
  • Invited
• [Presentation] Mucosal integreated immunological seesaw between physiological and pathological inflammation
  • Author(s): Kiyono, H
  • Organizer: IEIIS 2012 Homeostatic Inflammation Symposium
  • Place of Presentation: 東京、一橋記念講堂
  • Invited
• [Presentation] Spick and Span in Intestional Immunity: From Mucosal Homeostasis to Vaccine Development
  • Author(s): Kiyono, H
  • Organizer: The 35th General Meeting of Turkish Society of Microbiology
  • Place of Presentation: Izmir, Turkey
  • Invited
• [Presentation] The Mucosal Gateway System for Antigen-sampling and Homestatic Niche.
  • Author(s): Kiyono, H
  • Organizer: The 15th International Congress of Mucosal Immunology
  • Place of Presentation: Paris, France
  • Invited
• [Presentation] Spick-and-Span for the Development of Transgenic-Rice (MucoRice) based Oral Vaccine
  • Author(s): Kiyono, H
  • Organizer: International Union of Microbiological Societies 2011
  • Place of Presentation: 札幌、札幌コンベンションセンター
  • Invited
• [Presentation] Mucosal Chaperoning Vaccines for Upper Respiratory Tract Infections
  • Author(s): Kiyono, H
  • Organizer: The 14th International Rhinologic Society and 30th International Symposium on Infection and Allergy of the Nose
  • Place of Presentation: 東京、ANAインターコンチネンタル東京
  • Invited
• [Presentation] Spick-and-Span in Mucosal Immunity: From Homeostasis to Vaccine Development
  • Author(s): Kiyono, H
  • Organizer: Todai International Forum 2011 System Biology and Genomic Medicine Forum
  • Place of Presentation: Paris, France
• [Presentation] Spick-and-Span for the Development of MucoRice and Nanoantibody for the Control of Viral and Bacterial Infection
  • Author(s): Kiyono, H
  • Organizer: 25th Annual Meeting of the Japanese Society for AIDS Research, International Symposium on “HIV and Mucosal Immunity”
  • Place of Presentation: 東京、ハイアットリージェンシー東京
  • Invited
• [Presentation] Mucosal Decisions of Mutualisum and Elimination for Surface barrier system
  • Author(s): Kiyono, H
  • Organizer: The 6th Annual International Symposium in Institute of Dermatological Science(IDS)
  • Place of Presentation: Seoul, Korea
  • Invited
• [Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価 (2017)
  • Author(s): 清野宏、幸 義和、中橋 理佳、畔上 達彦
  • Total Pages: 354
  • Publisher: シーエムシー出版
• [Book] Medical Science Digest (2016)
  • Author(s): Azegami, T. and Kiyono, H.
  • Publisher: New Science
• [Book] 実験医学 (2016)
  • Author(s): Nakahashi, R. and Kiyono, H.
  • Publisher: 羊土社
• [Book] 化学療法の領域 (2016)
  • Author(s): Kashima, K., Takeyama, N., Yuki, Y. and Kiyono, H.
  • Publisher: 医薬ジャーナル社
• [Book] リンパ学会誌 (2016)
  • Author(s): Nakahashi, R., Nagatake, T. and Kiyono, H.
  • Publisher: 株式会社ライフメディコム
• [Book] 歯界展望2017年特別号 (2016)
  • Author(s): Kishikawa, S. and Kiyono, H.
  • Publisher: 医歯薬出版株式会社
• [Book] 粘膜免疫の最新情報 (2016)
  • Author(s): Yoshihara, S. and Kiyono, H.
  • Total Pages: 5
  • Publisher: 日本口腔・咽頭科学会 事務局
• [Remarks] 東京大学医科学研究所炎症免疫学分野 業績
  • URL: http://www.ims.u-tokyo.ac.jp/enmen/science/s_2014jp.html