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Immunological crosstalk between nasal and reproductive mucosal tissue

Research Project

Project/Area Number 23229004
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

Kiyono Hiroshi  東京大学, 医科学研究所, 教授 (10271032)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥214,760,000 (Direct Cost: ¥165,200,000、Indirect Cost: ¥49,560,000)
Fiscal Year 2015: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2014: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2013: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Keywords粘膜免疫 / 経鼻ワクチン / HSV2 / アジュバント / 生殖免疫 / 性感染症 / ワクチン / ケモカイン / 細胞遊走 / 経鼻免疫 / 膣粘膜感染症 / 膣粘膜指向性関連分子 / エフェクターT細胞
Outline of Final Research Achievements

The antigen administration to the nasal mucosa induces not only the immune responses in the nasal mucosa but reproductive tissue even its distant parts in our body. Therefore, the elucidation of molecular and cellular mechanisms of the nasal-reproductive mucosal crosstalk would be connected for the development of next generation mucosal vaccine for sexually transmitted diseases caused by HIV and HSV. In this project, we aim to identify the responsible molecule for the crosstalk and finally and successfully identified the contribution of unique chemoattractant pathways. In addition, we confirmed the safety of the nasal vaccine with our novel mucosal vaccine developed by nanoparticles and found no dissemination of antigen to the brain in mice and monkey study and found its safety.
These results collectively indicated the successful establishment of basic approval methods for the mucosal vaccine targeting immunological crosstalk between nasal and reproductive mucosal tissue.

Assessment Rating
Verification Result (Rating)

B

Assessment Rating
Result (Rating)

A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Report

(9 results)
  • 2017 Research Progress Assessment (Verification Result) ( PDF )
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (164 results)

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article (85 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 78 results,  Acknowledgement Compliant: 18 results,  Open Access: 29 results) Presentation (71 results) (of which Int'l Joint Research: 13 results,  Invited: 61 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Critical role of TSLP-responsive mucosal DCs for the induction of nasal antigen-specific IgA response. Mucosal Immunol.2017

    • Author(s)
      Joo,S., Fukuyama, Y., Park,E-J., Yuki, Y., Kurashima, Y., Ziegler, S.F. and Kiyono,H.
    • Journal Title

      Mucosal Immunology

      Volume: - Issue: 4 Pages: 901-911

    • DOI

      10.1038/mi.2016.103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Critical role of intestinal interleukin-4 modulating regulatory T Cells for desensitization, tolerance, and inflammation of food allergy.2017

    • Author(s)
      Nakajima-Adachi, H., Shibahara, K., Fujimura, Y., Takeyama, J., Hiraide, E., Kikuchi, A., Murakami, H., Hosono, A., Nochi, T., Wakatsuki, Y., Shimojo, N., Kaminogawa, S., Sato, R., Kiyono, H. and Hachimura, S.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 2 Pages: e0172795-e0172795

    • DOI

      10.1371/journal.pone.0172795

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Seed Metabolome analysis of a transgenic rice line expressing cholera toxin B-subunit.2017

    • Author(s)
      Ogawa, T., Kashima, K., Yuki, Y., Mejima, M., Kurokawa, S., Okazawa, A., Kiyono, H. and Ohta, D.
    • Journal Title

      Science Reports

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.2017

    • Author(s)
      Kunisawa, J., Yagi, K., Ikegami, K., Hamazaki, Y., Suzuki, H., Nagatake, T., Kiyono, H., Kondoh, M., Nasu, A. and Setou, M.
    • Journal Title

      Journal of Controlled Release

      Volume: -

    • NAID

      120006551757

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Allograft inflammatory factor 1 is a regulator of transcytosis in M cells2017

    • Author(s)
      Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 14509-14509

    • DOI

      10.1038/ncomms14509

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The spleen is the site where mast cells are induced in the development of food allergy.2017

    • Author(s)
      Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, H. and Abe, R.
    • Journal Title

      International Immunology

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nanogel-based nasal ghrelin vaccine prevents obesity.2017

    • Author(s)
      Azegami, T., Yuki, Y., Sawada, S,, Mejima, M., Ishige, K., Akiyoshi, K., Itoh, H. and Kiyono H.
    • Journal Title

      Mucosal Immunology

      Volume: - Issue: 5 Pages: 1351-1360

    • DOI

      10.1038/mi.2016.137

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.2017

    • Author(s)
      Furuta, Y., Tsai, S-H., Kinoshita, M., Fujimoto, K., Okumura, R., Umemoto, E., Kurashima, Y, Kiyono, H., Kayama, H., Takeda, K.
    • Journal Title

      Mucosal Immunology

      Volume: 12 Issue: 2 Pages: e0172509-e0172509

    • DOI

      10.1371/journal.pone.0172509

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunology and Cell Biolog.2017

    • Author(s)
      Nelson, S., Kiyono, H. and Kurashima, Y.
    • Journal Title

      Immunology & Cell Biology

      Volume: 95 Issue: 2 Pages: 117-8

    • DOI

      10.1038/icb.2016.106

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA-mediated dynamic control of mucosal immunity in intestinal ecosystem.2017

    • Author(s)
      Park, EJ., Shimaoka, M. and Kiyono, H.
    • Journal Title

      International Immunology

      Volume: - Issue: 4 Pages: 157-163

    • DOI

      10.1093/intimm/dxx019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing.2017

    • Author(s)
      Kurashima, Y. and Kiyono, H.
    • Journal Title

      Annual Review of Immunology

      Volume: - Issue: 1 Pages: 51116-52424

    • DOI

      10.1146/annurev-immunol-051116-052424

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.2016

    • Author(s)
      Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H.
    • Journal Title

      Regul Toxicol Pharmacol

      Volume: 76 Pages: 128-136

    • DOI

      10.1016/j.yrtph.2016.01.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ISH NIA OS-02 attenuation of hypertension by less-invasive intranasal vaccination against angiotensin II type 1 receptor in spontaneously hypertensive rats.2016

    • Author(s)
      Azegami, T., Yuki, Y., Hayashi, K., Nakamura, M., Hishikawa, A., Kiyono, H. and Itoh, H.
    • Journal Title

      Journal of Hypertension

      Volume: 1 Pages: 42-42

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epithelial glycosylation in gut homeostasis and inflammation.2016

    • Author(s)
      Goto, Y., Uematsu, S. and Kiyono, H.
    • Journal Title

      Nature Immunology

      Volume: 17 Issue: 11 Pages: 1244-1251

    • DOI

      10.1038/ni.3587

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation.2016

    • Author(s)
      Lee, J., Park, E.J. and Kiyono H.
    • Journal Title

      BMB Reports

      Volume: 49 Pages: 263-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mucosal immunosenescence in the gastrointestinal tract: A mini-review.2015

    • Author(s)
      Sato, S., Kiyono, H. and Fujihashi, K.
    • Journal Title

      Gerontology

      Volume: - Issue: 4 Pages: 336-342

    • DOI

      10.1159/000368897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease.2015

    • Author(s)
      Suenaga, F., Ueha, S., Abe, J., Kosugi-Kanaya, M., Wang, Y., Yokoyama, A., Shono, Y., Shand, F. H., Morishita, Y., Kunisawa, J., Sato, S., Kiyono, H. and Matsushima, K.
    • Journal Title

      J. Immunol.

      Volume: 194(1) Issue: 1 Pages: 398-406

    • DOI

      10.4049/jimmunol.1401022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.2015

    • Author(s)
      Tsai, S-H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda, K.
    • Journal Title

      Immunity

      Volume: 42(2) Issue: 2 Pages: 279-293

    • DOI

      10.1016/j.immuni.2015.01.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determination of genomic location and structure of the transgenes in marker-free rice-based cholera vaccine by using whole genome resequencing approach.2015

    • Author(s)
      Mejima, M., Kashima, K., Kuroda, M., Takeyama, N., Kurokawa S., Fukuyama Y., Kiyono H., Itoh, K., Mitsui, T., and Yuki, Y.
    • Journal Title

      Plant Cell Tiss. Organ Cult.

      Volume: 120 Issue: 1 Pages: 35-48

    • DOI

      10.1007/s11240-014-0575-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques.2015

    • Author(s)
      Fukuyama, Y., Yuki, Y., Katakai, Y., Harada, N., Takahashi, H., Takeda, S., Mejima, M., Joo, S., Kurokawa, S., Sawada, S., Shibata, H., Park, EJ., Fujihashi., K, Briles, D., Yasutomi, Y., Tsukada, H., Akiyoshi, K., Kiyono, H.
    • Journal Title

      Mucosal Immunol.

      Volume: - Issue: 5 Pages: 1144-1153

    • DOI

      10.1038/mi.2015.5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel transgenic rice-based vaccines.2015

    • Author(s)
      Azegami, T., Itoh, H., Kiyono, H. and Yuki, Y.
    • Journal Title

      Arch. Immunol. Ther. Exp.

      Volume: 63(2) Issue: 2 Pages: 87-99

    • DOI

      10.1007/s00005-014-0303-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative whole-genome analyses of selection marker‐free rice-based cholera toxin B-subunit vaccine lines and wild-type lines.2015

    • Author(s)
      Kashima, K., Mejima, M., Kurokawa, S., Kuroda, M., Kiyono, H. and Yuki, Y.
    • Journal Title

      BMC Genomics

      Volume: 48 Issue: 1 Pages: 48-48

    • DOI

      10.1186/s12864-015-1285-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamins mediate immunological homeostasis and diseases at the surface of the body.2015

    • Author(s)
      Kunisawa J. and Kiyono H.
    • Journal Title

      Endocr. Metab. Immune Disord. Drug Targets

      Volume: 15(1) Issue: 1 Pages: 25-30

    • DOI

      10.2174/1871530314666141021114651

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα.2015

    • Author(s)
      Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
    • Journal Title

      Int. Immunol.

      Volume: - Issue: 6 Pages: 307-314

    • DOI

      10.1093/intimm/dxv004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] レチノイン酸代謝による皮膚バリアの恒常性維持-線維芽細胞によるマスト細胞調節機構-2015

    • Author(s)
      佐藤健、倉島洋介、國澤純、清野宏
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63(2) Pages: 139-145

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 腸管バリアとしての糖鎖修飾とその制御2015

    • Author(s)
      後藤義幸、清野宏
    • Journal Title

      実験医学

      Volume: 33(4) Pages: 544-549

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease.2014

    • Author(s)
      Sato, A., Suwanto, A., Okabe, M., Sato, S., Nochi, T., Imai, T., Koyanagi, N., Kunisawa, J., Kawaguchi, Y. and Kiyono, H.
    • Journal Title

      J Virol.

      Volume: 88(23) Issue: 23 Pages: 13699-13708

    • DOI

      10.1128/jvi.02279-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.2014

    • Author(s)
      Fujihashi, K., Sato S., and Kiyono, H.
    • Journal Title

      Exp. Gerontol.

      Volume: 54 Pages: 21-26

    • DOI

      10.1016/j.exger.2014.01.006

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Innate lymphoid cells regulate intestinal epithelial cell glycosylation.2014

    • Author(s)
      Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., Setoyama, H., Imaoka, A., Uematsu, S., Akira, S., Domino, S., Kulig, P., Becher, B., Renauld, J-C., Sasakawa, C., Umesaki, Y., Benno, Y. and Kiyono, H.
    • Journal Title

      Science

      Volume: 345(6202) Pages: 1254009-1254009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The enzyme cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.2014

    • Author(s)
      Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
    • Journal Title

      Immunity

      Volume: 40 Issue: 4 Pages: 530-541

    • DOI

      10.1016/j.immuni.2014.01.014

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Challenge in mucosal vaccines for the control of infectious diseases.2014

    • Author(s)
      Azegami, T., Yuki, Y., and Kiyono, H.
    • Journal Title

      Int. Immunol.

      Volume: 26 Issue: 9 Pages: 517-528

    • DOI

      10.1093/intimm/dxu063

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mucosal immune system for vaccine development.2014

    • Author(s)
      Lamichhane, A., Azegami, T. and Kiyono, H.
    • Journal Title

      Vaccine

      Volume: 32(49) Issue: 49 Pages: 6711-6723

    • DOI

      10.1016/j.vaccine.2014.08.089

    • NAID

      130007769774

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New era for mucosal mast cells : their roles in inflammation, allergic immune rasposes and adjuvant development.2014

    • Author(s)
      Kurashima Y, Kiyono H.
    • Journal Title

      Exp Mol Med.

      Volume: 46 Issue: 3 Pages: e83-e83

    • DOI

      10.1038/emm.2014.7

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.2014

    • Author(s)
      Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 9 Pages: 108294-108294

    • DOI

      10.1371/journal.pone.0108294

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine.2014

    • Author(s)
      Tokuhara, D., Nochi, T., Matsumura, A., Mejima, M., Takahashi, Y., Kurokawa, S., Kiyono, H. and Yuki Y.
    • Journal Title

      Dig. Dis. Sci.

      Volume: 59 Issue: 11 Pages: 2682-2692

    • DOI

      10.1007/s10620-014-3203-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.2014

    • Author(s)
      Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H.
    • Journal Title

      J. Immunol.

      Volume: 193 Issue: 4 Pages: 1666-1671

    • DOI

      10.4049/jimmunol.1302944

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.2014

    • Author(s)
      Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 5 Issue: 5 Pages: 790-9

    • DOI

      10.1097/mib.0000000000000017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch2014

    • Author(s)
      Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
    • Journal Title

      Nature Comm

      Volume: 5 Issue: 1 Pages: 3704-3704

    • DOI

      10.1038/ncomms4704

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice.2014

    • Author(s)
      Abe, M., et al.
    • Journal Title

      J. Biotechnol.

      Volume: - Pages: 45-52

    • DOI

      10.1016/j.jbiotec.2014.02.005

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 粘膜ワクチンを基盤とした次世代ワクチンの開発2014

    • Author(s)
      福山賀子、清野宏
    • Journal Title

      最新医学

      Volume: 69(4) Pages: 62-69

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 次世代ワクチン開発への課題と挑戦-経口ワクチン-2014

    • Author(s)
      鹿島光司、幸義和、清野宏
    • Journal Title

      BIO INDUSTRY

      Volume: 31(6) Pages: 4-10

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 抑制型免疫システムを応用した次世代型抗アレルギーワクチンの開発2014

    • Author(s)
      高里良宏、倉島洋介、清野宏、國澤純
    • Journal Title

      BIO INDUSTRY

      Volume: 31(6) Pages: 55-60

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 自然リンパ球による腸管上皮細胞の糖鎖修飾誘導・制御システム2014

    • Author(s)
      後藤義幸、清野宏
    • Journal Title

      分子消化器病

      Volume: 11(4) Pages: 86-88

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 細胞外核酸を介したマスト細胞の活性化と炎症性腸疾患2014

    • Author(s)
      倉島洋介、清野宏、國澤純
    • Journal Title

      生化学

      Volume: 86(6) Pages: 798-802

    • NAID

      40020314288

    • Related Report
      2014 Annual Research Report
  • [Journal Article] RNAi-mediated suppression of endogenous storage proteins leadsto a change in localization of overexpressed cholera toxinB-subunit and the allergen protein RAG2 in rice seeds.2014

    • Author(s)
      Kurokawa, S., et al.
    • Journal Title

      Plant Cell Rep.

      Volume: 33 Issue: 1 Pages: 75-87

    • DOI

      10.1007/s00299-013-1513-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.2014

    • Author(s)
      Takemura, N., et al.
    • Journal Title

      Nature Commun.

      Volume: 5 Issue: 1 Pages: 3492-3492

    • DOI

      10.1038/ncomms4492

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ENTPDase7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.2013

    • Author(s)
      Kusu, T., et al.
    • Journal Title

      J. Immunol.

      Volume: 190 Issue: 2 Pages: 774-783

    • DOI

      10.4049/jimmunol.1103067

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae2013

    • Author(s)
      Il Gyu Kong, Ayuko Sato, Yoshikazu Yuki, Tomonori Nochi, Haruko Takahashi, et al.
    • Journal Title

      Infection and Immunity

      Volume: (online) Issue: 5 Pages: 1625-34

    • DOI

      10.1128/iai.00240-13

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential roles of CCR5+ CCR6+ Dendritic cells induced by nasalovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.2013

    • Author(s)
      Fukuyama. Y., et al.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e60453-e60453

    • DOI

      10.1371/journal.pone.0060453

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice2013

    • Author(s)
      J. Kunisawa, M. Gohda, E. Hashimoto, I. Ishikawa, M. Higuchi, Y. Suzuki, Y. Goto, C. Panea, I. I. Ivanov, R. Sumiya, L. Aayam, T. Wake, S. Tajiri, Y. Kurashima, S. Shikata、S. Akira, K. Takeda, H. Kiyono
    • Journal Title

      Nat Commun.

      Volume: 10-1038 Issue: 1 Pages: 1038-1038

    • DOI

      10.1038/ncomms2718

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013

    • Author(s)
      Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
    • Journal Title

      Nat. Commun.

      Volume: 4 Issue: 1 Pages: 1949-1949

    • DOI

      10.1038/ncomms2949

    • NAID

      120005359107

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of dendritic cells in T cell retention in the inter-molecular region of Peyer's patches.2013

    • Author(s)
      Obata, T., et al.
    • Journal Title

      J. Immunol.

      Volume: 191 Issue: 2 Pages: 942-948

    • DOI

      10.4049/jimmunol.1200636

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of α-amylase/trypsin inhibitor-like protein family as major rice allergens.2013

    • Author(s)
      Kurokawa, S., et al.
    • Journal Title

      J. Proteome Res.

      Volume: 12 Issue: 7 Pages: 3372-3382

    • DOI

      10.1021/pr4002146

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.2013

    • Author(s)
      Tokuhara, D., et al.
    • Journal Title

      J. Clin. Invest.

      Volume: 123 Issue: 9 Pages: 3829-3838

    • DOI

      10.1172/jci70266

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells.2013

    • Author(s)
      Imai, T., et al.
    • Journal Title

      PLos One

      Volume: 8 Issue: 8 Pages: e72050-e72050

    • DOI

      10.1371/journal.pone.0072050

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.2013

    • Author(s)
      Yuki, Y., et al.
    • Journal Title

      Plant Biotechnol. J.

      Volume: 11 Issue: 7 Pages: 799-808

    • DOI

      10.1111/pbi.12071

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition2013

    • Author(s)
      Kishino S, Takeuchi M, Park S, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 44 Pages: 17808

    • DOI

      10.1073/pnas.1312937110

    • NAID

      120005341879

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin 15 and CD4+ T cells cooperate to promote small intestinal enteropathy in response to dietary antigen.2013

    • Author(s)
      Korneychuk N., et al.
    • Journal Title

      Gastroenterology

      Volume: 146(4) Issue: 4 Pages: 1017-1027

    • DOI

      10.1053/j.gastro.2013.12.023

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin-mediated regulation of intestinal immunity.2013

    • Author(s)
      Kunisawa, J., et al.
    • Journal Title

      Frontier in Immunol.

      Volume: 4 Pages: 189-189

    • DOI

      10.3389/fimmu.2013.00189

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nutritional components regulate the gut immune system and its association with intestinal immune disease development.2013

    • Author(s)
      Lamichhane, A., et al.
    • Journal Title

      J. Gastroenterol. Hepatol. Suppl.

      Volume: 4 Issue: S4 Pages: 18-24

    • DOI

      10.1111/jgh.12259

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation.2013

    • Author(s)
      Kurashima Y, Goto Y, Kiyono H.
    • Journal Title

      Eur J Immunol.

      Volume: 12 Issue: 12 Pages: 3108-3115

    • DOI

      10.1002/eji.201343782

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel-based antigen-delivery system for nasal vaccines.2013

    • Author(s)
      Yuki, Y., et al.
    • Journal Title

      Biotechnol. Genet. Eng. Rev.

      Volume: 29(1) Issue: 1 Pages: 61-72

    • DOI

      10.1080/02648725.2013.801226

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells2012

    • Author(s)
      Sato, S., et al.
    • Journal Title

      Mucosal Immunology

      Volume: 6 Issue: 4 Pages: 838-846

    • DOI

      10.1038/mi.2012.122

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors2012

    • Author(s)
      Y. Kurashima, T. Amiya, T. Nochi, K. Fujisawa, T. Haraguchi, H. Iba, H. Tsutsui, S. Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono
    • Journal Title

      Nat Commun.

      Volume: 3-1034 Issue: 1 Pages: 1034-1034

    • DOI

      10.1038/ncomms2023

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria2012

    • Author(s)
      G. F. Sonnenberg, L. A. Monticelli, T. Alenghat, T. C. Fung, N. A. Huntnick, J. Kunisawa, N. Shibata, S. Grunberg, Rohini Shinha, A. M. Zahm, M. R. Tardif, T. Sathaliyawala, M. Kubota, D. L. Farber, R. G. Collman, A. Shaked, L. A. Fouser, D. B. Weiner, P. A. Tessier, J. R Friedman, H. Kiyono, F. D. Bushman, K. Mi Chang, and David Artis.
    • Journal Title

      Science

      Volume: 336 Issue: 6086 Pages: 1321-1325

    • DOI

      10.1126/science.1222551

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of mature and functional human myeloid subsets in HSC engrafted NOD/SCID/IL2rγKO mice.2012

    • Author(s)
      Tanaka, S
    • Journal Title

      J. Immunol.

      Volume: 188 Issue: 12 Pages: 6145-6155

    • DOI

      10.4049/jimmunol.1103660

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon2012

    • Author(s)
      Jeon, Seong Gyu
    • Journal Title

      PLoS Pathog

      Volume: 8 Issue: 5 Pages: e1002714-e1002714

    • DOI

      10.1371/journal.ppat.1002714

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary folic Acid promotes survival of foxp3+ regulatory T cells in the colon2012

    • Author(s)
      Kinoshita, M.
    • Journal Title

      J. Immunol

      Volume: 189 Issue: 6 Pages: 2869-2878

    • DOI

      10.4049/jimmunol.1200420

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012

    • Author(s)
      Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
    • Journal Title

      Int Immunol.

      Volume: 24 Issue: 10 Pages: 613-623

    • DOI

      10.1093/intimm/dxs068

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Mucosal immune system of the respiratory tract.2012

    • Author(s)
      Sato, S
    • Journal Title

      Curr. Opin. Virol.

      Volume: 2 Issue: 3 Pages: 225-232

    • DOI

      10.1016/j.coviro.2012.03.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcaligenes is commensal bacteria habituating in the gut-associated lymphoid tissue for the regulation of the intestinal IgA responses.2012

    • Author(s)
      Kunisawa, J
    • Journal Title

      Frontier in Immunol.

      Volume: 3 Pages: 1-5

    • DOI

      10.3389/fimmu.2012.00065

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gut-associated lymphoid tissues for the development of oral vaccines.2012

    • Author(s)
      Kunisawa, J
    • Journal Title

      Adv Drug Deliv Rev.

      Volume: 64 Issue: 6 Pages: 523-530

    • DOI

      10.1016/j.addr.2011.07.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome2012

    • Author(s)
      Egawa, N., et al
    • Journal Title

      J.Virol.

      Volume: 86 Issue: 6 Pages: 3276-3281

    • DOI

      10.1128/jvi.06450-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of functioning human corneal endothelial cell line with high growth potential.2012

    • Author(s)
      Yokoi T, Seko Y, Yokoi T, Makino H, Hatou S, Yamada M, Kiyono T, Umezawa A, Nishina H, Azuma N.
    • Journal Title

      PLoS One

      Volume: 7(1) Issue: 1 Pages: e29677-e29677

    • DOI

      10.1371/journal.pone.0029677

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.2012

    • Author(s)
      Takagi, S
    • Journal Title

      Blood

      Volume: 119 Issue: 12 Pages: 2768-2777

    • DOI

      10.1182/blood-2011-05-353201

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel vaccine development strategies for inducing mucosal immunity.2012

    • Author(s)
      Fukuyama Y
    • Journal Title

      Expert Rev Vaccines

      Volume: 67 Issue: 3 Pages: 367-379

    • DOI

      10.1586/erv.11.196

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M cell-targeted mucosal vaccine strategies2012

    • Author(s)
      Yamamoto M
    • Journal Title

      Curr Top Microbiol Immunol.

      Volume: 354 Pages: 39-52

    • DOI

      10.1007/82_2011_134

    • ISBN
      9783642236921, 9783642236938
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological function of sphingosine 1-phosphate in the intestine.2012

    • Author(s)
      Kunisawa J
    • Journal Title

      Nutrients.

      Volume: 4 Issue: 3 Pages: 154-166

    • DOI

      10.3390/nu4030154

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The airway antigen sampling system : respiratory M cells as an alternative gateway for inhaled antigens2011

    • Author(s)
      Kim DY, et al
    • Journal Title

      J Immunol

      Volume: 186(7) Issue: 7 Pages: 4253-4262

    • DOI

      10.4049/jimmunol.0903794

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine.2011

    • Author(s)
      Okada K
    • Journal Title

      Adv Othrhinolaryngol.

      Volume: 72 Pages: 31-36

    • DOI

      10.1159/000324591

    • ISBN
      9783805597227, 9783805597234
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A tecpr1-dependent selective autophagy pathway targets bacterial pathogens2011

    • Author(s)
      Kawalec M, Reichhart JM, Sasakawa C
    • Journal Title

      Cell Host Microbe

      Volume: 9 Issue: 5 Pages: 376-389

    • DOI

      10.1016/j.chom.2011.04.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy.2011

    • Author(s)
      Burggraf, M.
    • Journal Title

      Mol Nutr Food Res

      Volume: 55 Issue: 10 Pages: 1475-1483

    • DOI

      10.1002/mnfr.201000634

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host pathogens. Editorial overview.2011

    • Author(s)
      Stappenbeck T
    • Journal Title

      Curr Opin Immunol.

      Volume: 23 Issue: 4 Pages: 445-447

    • DOI

      10.1016/j.coi.2011.07.017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery.2011

    • Author(s)
      Kim SH
    • Journal Title

      Eur J Immunol.

      Volume: 41 Issue: 11 Pages: 3219-3229

    • DOI

      10.1002/eji.201141592

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial barrier : an interface for the cross-communication between gut flora and immune system2011

    • Author(s)
      Goto, Y., Kiyono, H.
    • Journal Title

      Immunol Rev.

      Volume: 245 Issue: 1 Pages: 147-163

    • DOI

      10.1111/j.1600-065x.2011.01078.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腸管マルチエコシステムによる炎症制御2017

    • Author(s)
      Kiyono, H.
    • Organizer
      The 17th Symposium on Japanese Society for Pediatoric Inflammatory Bowel Disease
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2017-02-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of miRNA candidates as biomarkers for prediction and evaluation of mucosal vaccination2017

    • Author(s)
      Nakahashi, R.
    • Organizer
      The 10th Meeting of the Japanese Vaccine Adjuvant Research Consortium,
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2017-01-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] コメ型経口ワクチンMucoRice開発プロジェクト2017

    • Author(s)
      Kiyono H.
    • Organizer
      Joint Symposium of The University of Tokyo and Institute of Industrial Science, Activities lead by NY Office,
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2017-01-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ガーナにおける感染症サーベイランス体制強化とコレラ菌・HIVなどの腸管粘膜感染防御に関する研究2016

    • Author(s)
      Kiyono H.
    • Organizer
      Japan Agency for Medical Research and Development’s 革新的医療技術創出拠点project Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-12-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intenstinal M cells contribute to maintenance of gut immune homeostasis2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 45th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-12-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cutting Edge of Mucosal Immunology and Its Clinical Application2016

    • Author(s)
      Kiyono H.
    • Organizer
      International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
    • Place of Presentation
      Kuara Lumpur, Malaysia
    • Year and Date
      2016-11-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of Epithelial Clycosylation by Mucosal Immunity and Gut Microbiota2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 23rd General meeting of the Japanese Association for Dental Science
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2016-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カチオン化ナノゲルデリバリーシステムを用いた次世代型経鼻ワクチンの開発2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 20th Annual meeting of the Japanese Society for Vaccinology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Epithelial Cells-Innate Lymphoid Cells-Th Cells Trio-regulation for Gut Homeostasis and Inflammation2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 4th Annual Meeting of the International Cytokine and Interferon Society
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epithlial Cells-Innate Lymphoid Cells-T Cells Trio-regulation for Gut homeostasis and Inflammation2016

    • Author(s)
      Kiyono H.
    • Organizer
      International Cytokine & Interferon Society, ICIS Cytokines 2016
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 粘膜免疫の最新情報と炎症性疾患の制御に向けた経粘膜治療戦略2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 29th Annual Meeting of Japan Society of Stomata-pharyngology
    • Place of Presentation
      Matsue-shi, Shimane-ken
    • Year and Date
      2016-09-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Uniqueness of Mucosa-associated Lymphoid Tissues for Clinical Application2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 40th Annual Meeting of the Japanese Society of Lymphology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Innate lymphoid cell and T cell synchronously regulate gut epithelial cell fucosylation2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 10th International Symposium on Glycosyltransferases
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MucoRice and NanoGel: New Generation of Mucosal Vaccines for Aero-digestive Infectious Diseases2016

    • Author(s)
      Kiyono H.
    • Organizer
      HWASUN International Vaccine Forum
    • Place of Presentation
      Hwasun, Korea
    • Year and Date
      2016-06-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mucosal Multi-ecosystem for the Induction and Regulation of Symbiosis and Protection2016

    • Author(s)
      Kiyono H.
    • Organizer
      The 60th Annual General Assembly and Scientific Meeting of the Japan Colleage of Rheumatology.
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-04-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] “Mucosal Innate Lymphoid Cells and Mast Cells for the Regulation of Symbiosis and Inflammation”2015

    • Author(s)
      Kiyono, H.
    • Organizer
      World Immune Regulation Meeting IX
    • Place of Presentation
      Davos, Switzerland.
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Innovative Oral Vaccine:MucoRice”2015

    • Author(s)
      Kiyono, H.
    • Organizer
      “2015 Seminar for the Quality and Safety Improvements of Dental Practice” Kanagawa Dental Association
    • Place of Presentation
      Kanagawa, Japan.
    • Year and Date
      2015-03-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “The Mucosal Immune System for Symbiosis and Elimination”2015

    • Author(s)
      Kiyono, H.
    • Organizer
      The 34th Shirokane Symposium, The 50th Anniversary of Founding of the Kitasato University School of pharmacy
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Mucosal Immunity: The Adaptation of oral-Digestive Immune System for Vaccine Development”2015

    • Author(s)
      Kiyono, H.
    • Organizer
      The 3rd Medical Advisor Workshop, The Academy of Clinical Dentistry
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2015-02-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Gut Microflora Influences Pathology in the Kawasaki Disease (KD) VasculitisMouse Model2015

    • Author(s)
      Wakita, D., Kurashima, Y., Takasato, Y., Lee, Y., Shimada, K., Chen, S., Crother, T. R., Fishbein, M. C., Lehman, T.J.A., Kiyono, H., and Arditi , M.
    • Organizer
      International Kawasaki Disease Symposium
    • Place of Presentation
      Hawaii, USA.
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Advancing the Knowledge of Immunology for Disease Treatments.”2015

    • Author(s)
      Kiyono, H.
    • Organizer
      Science Council of Japan and The Pharmaceutical Society of Japan Symposium
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.2014

    • Author(s)
      Goto, Y., Panea, C., Lee, C. and Ivanov, I.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] E-NPP3 (CD203c) negatively regulates ATP-dependent allergic responses by basophils and mast cells.2014

    • Author(s)
      Tsai, S-H., Kinoshita, M., Kayama, H., Okuma, R., Kiyono, H., Karasuyama, H. and Takeda, K.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Loss of lymph node fibroblastic reticular cells and high endothelial cells underlies humoral immunodeficiency in mouse GVHD.2014

    • Author(s)
      Ueha, S., Suenaga, F., Abe, J., Kosugi, M., Shono, Y., Kunisawa, J., Sato S., Kiyono, H. and Matsushima, K.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Resistance to helminthic infection is dependent on mast cell activation mediated by ATP in Spi-B-deficient mice.2014

    • Author(s)
      Shimokawa, C., Kanaya, T., Ishikawa, K., Kurashima Y., Kiyono, H., Kaisho T. and Ohno, H.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology, Kyoto
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Critical role of TSLP-TSLPR interaction in inducing secretory IgA responses after mucosal immunizations.2014

    • Author(s)
      Joo, S., Fukuyama, Y., Yuki Y., Kurashima, Y., Ziegler, S.F., Park E-J. and Kiyono, H.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto, Japan.
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vaginal resident memory T cells induced by intranasal vaccination are critical for early clearance of genital HSV-2 infection.2014

    • Author(s)
      Suwanto, A., Sato A., Sato S., Nochi, T., Kunisawa, J. and Kiyono, H.
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Rice Protein Body and Cationic Nanogel as Antigen Delivery Vehicle for Mucosal Vaccines”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      8th International Symposium on Nanomedicine (ISNM2014)
    • Place of Presentation
      Matsuyama, Ehime.
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Microbial Molding of Mucosal Immunity”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      ACR/ARHP Annual Meeting
    • Place of Presentation
      Boston, USA.
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Rice-based Oral Vaccine “MucoRice” for the Control of Enteric Diarrheal Disease”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 62nd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Cross-talk between the Mucosal Immune System and Environmental Factors”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      11th Nestlé International Nutrition Symposium on “Nutrition and the Human Gut Microbiome”
    • Place of Presentation
      Lausanne, Switzerland.
    • Year and Date
      2014-10-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Mucosal Innate Immune System and Vaccine Development”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 1st International Symposium on Mucosal Immunity and Vaccine Development 2014.
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Tissue-specific signals control mast cell function for the maintenance of tissue homeostasis”2014

    • Author(s)
      Kurashima, Y.
    • Organizer
      The 1st International Symposium on Mucosal Immunity and Vaccine Development 2014.
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] "Mucosal Connections Between Airway and Reproductive Immunity"2014

    • Author(s)
      Kiyono, H.
    • Organizer
      10th Research Symposium on Human Natural Defense System in Conjunction with PRAMS 2014 in Commemoration of the 10th Anniversary of The Airway Mucus Institute
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tissue-specific signals control mast cell function for the maintenance of tissue homeostasis2014

    • Author(s)
      Kurashima, Y.
    • Organizer
      2nd Novo Nordisk Innovation Summit 2014
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Mucosal Links between Innate-epithelial Cells and Commensal Flora for the Development of New Immune-prevention and -therapy”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      2nd Novo Nordisk Innovation Summit 2014
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Development of Next Generation Vaccine based on Mucosal Immunology~Future of Mucosal Vaccine”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 65th Kanto Region Otorhinolaryngology Allergy Discussion Group
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-09-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Innate Lymphoid Cells Regulate Intestinal Epithelial Cell Fucosylation for Symbiosis and Elimination”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 26th Symposium on Microbial Sciences ~The Symphony of Microbial Science and Medical care~
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Trends in Immunological Memory and Vaccine Development”, Organizer and Speaker, “Mucosal Immunity and Vaccine Development”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 2nd Symposium of International Immunological Memory and Vaccine Forum, (IIMVF)
    • Place of Presentation
      La Jolla, USA.
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Whole genome analysis of selection marker-free MucoRice-CTB, a rice-based oral cholera vaccine2014

    • Author(s)
      Kashima, K.
    • Organizer
      International Plant Biotechnology Association
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2014-08-10 – 2014-08-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] “Oral Vaccine, MucoRice Fighting against the Diarrhea”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      JSI organized Public Lecture Series Meneki Fushigi Mirai 2014.
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-08-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Reciprocal Cooperation of Intra-tissue Commensal Bacteria, Innate Lymphoid Cells and Mast Cells for the Integrated Mucosal Immunoregulation”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 38th Aso Symposium 2014.
    • Place of Presentation
      Kumamoto, Japan.
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Development of Mucosal Immunology Driven Rice-based Vaccine “MucoRice” by the Fusion Research of Medical, Agricultural and Engineering Sciences”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      The 13th Shikoku Immunology Forum 2014
    • Place of Presentation
      Tokushima, Japan.
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Mucosal Connections between Microbial Ecology and Immunity for the Homeostasis and Inflammatory Responses”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      7th International Immunonutrition Workshop -Eating for Preventing-
    • Place of Presentation
      Carovigno, Italy.
    • Year and Date
      2014-05-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ”Fusion of Medical, Plant and Engineering Science Led to the Creation of Rice-based Vaccine, MucoRice”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      SKIL Future Forum -Science Leads to Safe Life-
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-04-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] “Can We Prevent Infectious Diseases by Rice?”2014

    • Author(s)
      Kiyono, H.
    • Organizer
      Seminar for Knowledge of Hub, National University Joint Usage-Research Center
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2014-04-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Intestinal Microbiota for Mucosal Decision of Immunity and Tolerance2013

    • Author(s)
      Kiyono, H.
    • Organizer
      International Yakult Symposium 2013 on “The Intestinal Microbiota and Probiotics: Exploiting Their Influence on Health”
    • Place of Presentation
      London, UK.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mucosal Connection for Immunity, Tolerance and Commensal Microbiota2013

    • Author(s)
      Kiyono, H.
    • Organizer
      JSPS: France-Japan Joint Forum “Frontiers inInnate Immunity”
    • Place of Presentation
      Strasbourg, France.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immune Regulation and Monitoring at the Epithelial Surface of the Intestine2013

    • Author(s)
      Kiyono, H.
    • Organizer
      Fondation Mérieux: Targeting Commensal Flora to Better Shape Protective Immune Responses for Better Disease Prevention and Therapy
    • Place of Presentation
      Annucy, France.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immunological Interventions and Vaccine Development for the Elderly2013

    • Author(s)
      Kiyono, H.
    • Organizer
      ICI 15th Satellite Symposium “Aging and the Immune System”
    • Place of Presentation
      Milan, Italy.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The Mucosal immune system for New Generation of Prophylaxis and Therapeutic Nasal and Oral vaccines2013

    • Author(s)
      Kiyono, H.
    • Organizer
      The 7th International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
    • Place of Presentation
      Shimane, Japan.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] MucoRice System for New Generation of Prophylaxis and Therapeutic Oral Vaccine2013

    • Author(s)
      Kiyono, H.
    • Organizer
      The 7th Vaccine & ISV Congress
    • Place of Presentation
      Barcelona, Spain.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The Intestinal Immune System for Mucosal Connections of Immunity, Commensal Microbiota and Vaccine2013

    • Author(s)
      Kiyono, H.
    • Organizer
      2013 Joint Meeting of the 13th Aaian Pan-pacific Society for Pediatric Gastroenterology, Hepatology and Nuritutionand the 40th Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition
    • Place of Presentation
      Tokyo, Japan.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Reverse Control of ATP-P2X7-dependent Mast Cells in Mucosa and Skin for Inflammation2013

    • Author(s)
      Kiyono, H.
    • Organizer
      Annual Meeting of the French Society for Immunology
    • Place of Presentation
      Paris, France.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mast Cells and Innate Lymphoid Cells for “Mucosal Barrier and Inflammation2013

    • Author(s)
      Mast Cells and Innate Lymphoid Cells for “Mucosal Barrier and Inflammation
    • Organizer
      Germany-Japan Immunology Seminar 2013 -Challenge in Immunology for Opening the Undestanding of Human Immune System and Disease-
    • Place of Presentation
      Shizuoka, Japan.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] MucoRice: Rice-based Oral Vaccine Development

    • Author(s)
      Kiyono, H
    • Organizer
      Molecular Immunology & Immunogenetics Congress 2012
    • Place of Presentation
      Antalya, Turkey
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mucosal Innate Immune System for Mutalisum, Inflammation and Elimination

    • Author(s)
      Kiyono, H
    • Organizer
      The 4th Microbial Pathogenesis & Immunity Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mucosal Integration of Mutualism and Elimination for Surface barrier System

    • Author(s)
      Kiyono, H
    • Organizer
      International Meeting of the Microbioligical Society of Korea
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mucosal integrated immunological seesaw between mutualization and elimination in the intestine

    • Author(s)
      Kiyono, H
    • Organizer
      The 19th East Asia Joint Symposium on Biomedical Research "Moleculer Understanding for Physiology and Pathology."
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mucosal Vaccine for the Control of Infectious Diseases

    • Author(s)
      Kiyono, H
    • Organizer
      STS International Forum 9th Annual Meeting
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Spick-and-span in mucosal vaccine development

    • Author(s)
      Kiyono, H
    • Organizer
      The 34th Naito Conference on Infection, Immunity and their Contral for Health: Mucosal Barrier, Pathogen and Vaccine
    • Place of Presentation
      札幌、シャトレーゼ ガトーキングダムサッポロ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Spick-and-span in Mucosal Immunity: From Intestional Homeostasis to Vaccine Develipment

    • Author(s)
      Kiyono, H
    • Organizer
      A-IMBN Symposium
    • Place of Presentation
      Jeju , Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] MucoRice: Fusion of Mucosal immunology and plant biology ked to the development of rice-based oral vaccine

    • Author(s)
      Kiyono, H
    • Organizer
      The 10th International Congress on Plant Molecular Biology
    • Place of Presentation
      Jeju , Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mucosal integreated immunological seesaw between physiological and pathological inflammation

    • Author(s)
      Kiyono, H
    • Organizer
      IEIIS 2012 Homeostatic Inflammation Symposium
    • Place of Presentation
      東京、一橋記念講堂
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Spick and Span in Intestional Immunity: From Mucosal Homeostasis to Vaccine Development

    • Author(s)
      Kiyono, H
    • Organizer
      The 35th General Meeting of Turkish Society of Microbiology
    • Place of Presentation
      Izmir, Turkey
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The Mucosal Gateway System for Antigen-sampling and Homestatic Niche.

    • Author(s)
      Kiyono, H
    • Organizer
      The 15th International Congress of Mucosal Immunology
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Spick-and-Span for the Development of Transgenic-Rice (MucoRice) based Oral Vaccine

    • Author(s)
      Kiyono, H
    • Organizer
      International Union of Microbiological Societies 2011
    • Place of Presentation
      札幌、札幌コンベンションセンター
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Mucosal Chaperoning Vaccines for Upper Respiratory Tract Infections

    • Author(s)
      Kiyono, H
    • Organizer
      The 14th International Rhinologic Society and 30th International Symposium on Infection and Allergy of the Nose
    • Place of Presentation
      東京、ANAインターコンチネンタル東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Spick-and-Span in Mucosal Immunity: From Homeostasis to Vaccine Development

    • Author(s)
      Kiyono, H
    • Organizer
      Todai International Forum 2011 System Biology and Genomic Medicine Forum
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spick-and-Span for the Development of MucoRice and Nanoantibody for the Control of Viral and Bacterial Infection

    • Author(s)
      Kiyono, H
    • Organizer
      25th Annual Meeting of the Japanese Society for AIDS Research, International Symposium on “HIV and Mucosal Immunity”
    • Place of Presentation
      東京、ハイアットリージェンシー東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Mucosal Decisions of Mutualisum and Elimination for Surface barrier system

    • Author(s)
      Kiyono, H
    • Organizer
      The 6th Annual International Symposium in Institute of Dermatological Science(IDS)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      清野宏、幸 義和、中橋 理佳、畔上 達彦
    • Total Pages
      354
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] Medical Science Digest2016

    • Author(s)
      Azegami, T. and Kiyono, H.
    • Publisher
      New Science
    • Related Report
      2015 Annual Research Report
  • [Book] 実験医学2016

    • Author(s)
      Nakahashi, R. and Kiyono, H.
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report
  • [Book] 化学療法の領域2016

    • Author(s)
      Kashima, K., Takeyama, N., Yuki, Y. and Kiyono, H.
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Annual Research Report
  • [Book] リンパ学会誌2016

    • Author(s)
      Nakahashi, R., Nagatake, T. and Kiyono, H.
    • Publisher
      株式会社ライフメディコム
    • Related Report
      2015 Annual Research Report
  • [Book] 歯界展望2017年特別号2016

    • Author(s)
      Kishikawa, S. and Kiyono, H.
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 粘膜免疫の最新情報2016

    • Author(s)
      Yoshihara, S. and Kiyono, H.
    • Total Pages
      5
    • Publisher
      日本口腔・咽頭科学会 事務局
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学医科学研究所炎症免疫学分野 業績

    • URL

      http://www.ims.u-tokyo.ac.jp/enmen/science/s_2014jp.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2011-06-18   Modified: 2019-07-29  

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