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The mechanisms of development and differentiation in Valpha14 NKT cells

Research Project

Project/Area Number 23229005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Taniguchi Masaru  国立研究開発法人理化学研究所, 統合生命医科学研究センター, グループディレクター (80110310)

Co-Investigator(Kenkyū-buntansha) KOJO Satoshi  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (70360542)
HARADA Michishige  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (20333487)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥107,380,000 (Direct Cost: ¥82,600,000、Indirect Cost: ¥24,780,000)
Fiscal Year 2015: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2014: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2013: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2012: ¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2011: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
KeywordsNKT細胞サブタイプ / NKT細胞特異的転写因子 / NKT細胞新規分化経路 / エピゲノム解析 / NKT細胞分化新規経路 / Th1関連遺伝子 / 肝臓 NKT細胞 / NKT細胞 / 転写因子 / 分化経路 / エピジェネティック制御 / NKT細胞前駆細胞 / iPS / 単一細胞PCR / RNA-sequence / リンパ球分化 / サイトカイン産生 / high throughput RT-qPCR / 発生分化 / 機能分化 / Vα14Jα18受容体遺伝子 / shRNA / レンチウイルベクター
Outline of Final Research Achievements

Natural killer T (NKT) cells are characterized by the expression of the single invariant Va14 receptor recognizing glycolipid antigens in the association with monomorphic CD1d molecule. However, their developmental pathway and molecular basis of their development remain unclear.
Here, we identified the novel developmental pathway for NKT cells directly generated from late DN stage precursors bypassing through DP stage and mainly migrated to the liver, but not to the fat, mesenteric lymphnode and lamina propria, where DP-derived NKT cells are migrated. We also found that 15 transcription factors, including Ring family proteins, were selectively expressed in DN-derived preNKT cells without surface Va14 receptor. Some of these TFs were shown to be responsible for NKT cell development in their knock-out mice. In addition, we succeeded to detect alteration of epigenetic modification responsible gene loci that regulate NKT cell development and function during NKT cell development.

Assessment Rating
Verification Result (Rating)

A-

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(9 results)
  • 2016 Research Progress Assessment (Verification Result) ( PDF )
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (57 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (31 results) (of which Int'l Joint Research: 2 results,  Invited: 20 results) Remarks (1 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation.2016

    • Author(s)
      Kaji T, Hijikata A, Ishige A, Kitami T, Watanabe T, Ohara O, Yanaka N, Okada, M, Shimoda M, Taniguchi M, Takemori T.
    • Journal Title

      Int Immunol.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire.2016

    • Author(s)
      Dashtsoodol N, Shigeura T, Ozawa R, Harada M, Kojo S, Watanabe T, Koseki H, Nakayama M, Ohara O, Taniguchi M.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 4 Pages: 1-10

    • DOI

      10.1371/journal.pone.0153347

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.2015

    • Author(s)
      Karisola P, Lehto M, Kinaret P, Ahonen N, Haapakoski R, Anthoni M, Taniguchi M, Wolff H, Puustinen A, Alenius H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0129446-e0129446

    • DOI

      10.1371/journal.pone.0129446

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy2015

    • Author(s)
      Taniguchi M, Harada M, Dashtsoodol N, Kojo S.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 91 Issue: 7 Pages: 292-304

    • DOI

      10.2183/pjab.91.292

    • NAID

      130005088948

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar Pollen Allergen-Sensitized Monkeys.2015

    • Author(s)
      Fujimura T, Fujinami K, Ishikawa R, Tateno M, Tahara Y, Okumura Y, Ohta H, Miyazaki H, Taniguchi M.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: 168 Issue: 1 Pages: 132-143

    • DOI

      10.1159/000441141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor2015

    • Author(s)
      Taniguchi M, Harada M, Nyambayar D, Kojo S
    • Journal Title

      The Proceedings of the Japan Academy Series B

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.2015

    • Author(s)
      Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9083-9083

    • DOI

      10.1038/srep09083

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organ-specific protective role of NKT cells in virus-induced inflammatory2015

    • Author(s)
      Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M, Tsunoda I.
    • Journal Title

      Journal of Neuroimmunology

      Volume: 278 Pages: 174-184

    • DOI

      10.1016/j.jneuroim.2014.11.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KLRG+ invariant natural killer T cells are long-lived effectors.2014

    • Author(s)
      Shimizu K, Sato Y, Shinga J, Watanabe T, Endo T, Asakura M, Yamasaki S, Kawahara K, Kinjo Y, Kitamura H,Watarai H, Ishii Y, Tsuji M, Taniguchi M, Ohara O, Fujii S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 34 Pages: 12474-12479

    • DOI

      10.1073/pnas.1406240111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell.2014

    • Author(s)
      Ren Y, Dashtsoodol N, Watarai H, Koseki H, Quan C, Taniguchi M.
    • Journal Title

      International Immunology

      Volume: 26 Issue: 10 Pages: 551-561

    • DOI

      10.1093/intimm/dxu057

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel approach inducing transplant tolerance by activated invariant natural killer T cells with blockade.2014

    • Author(s)
      Hirai T, Ishii Y, Ikemiyagi M, Fukuda E, Omoto K, Namiki M, Taniguchi M, Tanabe K.
    • Journal Title

      Am J Transplant.

      Volume: 14 Issue: 3 Pages: 1-14

    • DOI

      10.1111/ajt.12606

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKT cells as an ideal target for anti-tumor immunotherapy2013

    • Author(s)
      Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M
    • Journal Title

      Front. Immunol

      Volume: 4 Pages: 409-409

    • DOI

      10.3389/fimmu.2013.00409

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry2013

    • Author(s)
      Oh-hora, M., et al.
    • Journal Title

      Immunity

      Volume: 38 Issue: 5 Pages: 1-15

    • DOI

      10.1016/j.immuni.2013.02.008

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines2012

    • Author(s)
      Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M
    • Journal Title

      PLoS Biol

      Volume: 10 Issue: 2 Pages: e1001255-e1001255

    • DOI

      10.1371/journal.pbio.1001255

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance2012

    • Author(s)
      Satoh, M., Andoh, Y., Clingan, S. C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K. Iwabuchi, K
    • Journal Title

      PLoS ONE

      Volume: 7(2) Issue: 2 Pages: 1-12

    • DOI

      10.1371/journal.pone.0030568

    • NAID

      120004043739

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of Activated Invariant Natural Killer T Cells in the Tumor Microenvironment after α-Galactosylceramide-Pulsed Antigen Presenting Cells.2012

    • Author(s)
      Nagato K, Motohashi S, Ishibashi F, Okita K, Yamasaki K, Moriya Y, Hoshino H, Yoshida S, Hanaoka H, Fujii SI, Taniguchi M, Yoshino I, Nakayama T.
    • Journal Title

      J Clin Immunol.

      Volume: 32 Issue: 5 Pages: 1071-81

    • DOI

      10.1007/s10875-012-9697-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy.2012

    • Author(s)
      Watarai H, Yamada D, Fujii S, Taniguchi M, Koseki H.
    • Journal Title

      Int J Hematol.

      Volume: 95 Issue: 6 Pages: 624-31

    • DOI

      10.1007/s12185-012-1091-0

    • NAID

      10030793480

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines.2012

    • Author(s)
      Tashiro T, Shigeura T, Watarai H, Taniguchi M, Mori K.
    • Journal Title

      Bioorg Med Chem.

      Volume: 20 Issue: 14 Pages: 4540-8

    • DOI

      10.1016/j.bmc.2012.05.073

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice.2012

    • Author(s)
      Sobirin MA, Kinugawa S, Takahashi M, Fukushima A, Homma T, Ono T, Hirabayashi K, Suga T, Azalia P, Takada S, Taniguchi M, Nakayama T, Ishimori N, Iwabuchi K, Tsutsui H.
    • Journal Title

      Circ Res.

      Volume: 111 Pages: 1037-47

    • NAID

      120005228375

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A limited role of iNKT cells in controlling systemic Candida albicans infections.2012

    • Author(s)
      Tarumoto N, Kinjo Y, Ueno K, Okawara A, Watarai H, Taniguchi M, Maesaki S, Miyazaki Y.
    • Journal Title

      Jpn J Infect Dis.

      Volume: 65 Pages: 522-526

    • NAID

      130002588761

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] A validation of the requirement for Vα14 NKT cells for tumor rejection using newly generated Traj18-deficient mice with undisturbed T cell receptor repertoire2015

    • Author(s)
      Nyambayar Dashtsoodol
    • Organizer
      CD1-MR1 2015
    • Place of Presentation
      Mantra, Lorne, Australia
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Alternative developmental pathway of a Va14+ NKT cell subset bypassing CD4+CD8+ double positive stage2015

    • Author(s)
      Masaru Taniguchi
    • Organizer
      CD1-MR1 2015
    • Place of Presentation
      Mantra, Lorne, Australia
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アレルギー疾患克服の未来2014

    • Author(s)
      谷口克
    • Organizer
      第51回日本小児アレルギー学会
    • Place of Presentation
      四日市市文化会館、四日市市
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新しい免疫細胞治療概念の実践2014

    • Author(s)
      谷口克
    • Organizer
      第23回神戸ラボ全体研究会議
    • Place of Presentation
      神戸大学、神戸市
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NKT細胞の発見から臨床応用まで2014

    • Author(s)
      谷口克
    • Organizer
      第16回免疫サマースクールin小豆島
    • Place of Presentation
      オリビアン小豆島、小豆島
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新しい概念に基づくがん免疫治療2014

    • Author(s)
      谷口克
    • Organizer
      第10回広島肝臓プロジェクト研究センターシンポジウム
    • Place of Presentation
      ホテルグランヴィア広島、広島市
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NKT cell -mediated adjuvant cell therapy on lung cancer and head and neck cancer2014

    • Author(s)
      Taniguchi M
    • Organizer
      FOCIS2014
    • Place of Presentation
      Chicago,USA
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新しい概念に基づくがん治療標的2014

    • Author(s)
      谷口克
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場、大阪市
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Challenge in Immunology for Opening the Door to the Understanding of Human System and Disease- IMS-RCAI Medical Innovation Programs based on the NKT cell biology.2013

    • Author(s)
      Taniguchi M.
    • Organizer
      Germany-Japan Immunology Seminar 2013
    • Place of Presentation
      Shizuoka / JAPAN
    • Year and Date
      2013-12-07
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新しい概念に基づくがん治療標的-NKT細胞-2013

    • Author(s)
      谷口克
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2013-10-17
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Discovery of NKT cells and their clinical application.2013

    • Author(s)
      Taniguchi M.
    • Organizer
      12th International Symposium on Sjoren's Syndrome
    • Place of Presentation
      Kyoto / JAPAN
    • Year and Date
      2013-10-09
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Characterization of the cell with NKT cell potential in DN1 thymic fraction.2013

    • Author(s)
      Taniguchi M.
    • Organizer
      7th INTERNATIONAL SYMPOSIUM ON CD1 AND NKT CELLS
    • Place of Presentation
      Tours / FRANCE
    • Year and Date
      2013-09-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NKT cells as an ideal target for anti-tumor immunotherapy.2013

    • Author(s)
      Taniguchi M.
    • Organizer
      15TH INTERNATIONAL CONGRESS OF IMMUNOLOGY
    • Place of Presentation
      Milan / ITALY
    • Year and Date
      2013-08-25
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新しい概念に基づく難治アレルギー疾患の根本治療標的2013

    • Author(s)
      谷口克
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-05-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] NKT Cell-mediated Adjuvant Activity on Antitumor Responses2012

    • Author(s)
      Taniguchi M
    • Organizer
      FOCIS2012
    • Place of Presentation
      Vancouver(Canada)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NKT細胞サブセットとその機能

    • Author(s)
      谷口克
    • Organizer
      神戸大生化学セミナー
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] NKT細胞系-新しい免疫療法の標的

    • Author(s)
      谷口克
    • Organizer
      第112回日本外科学定期学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NKT cell subsets and their functions

    • Author(s)
      Taniguchi M
    • Organizer
      Innovation Summit Tokyo 2012-Chronic Inflammation and Autoimmune Deseases
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] NKT細胞サブタイプと機能-その臨床応用に向けて-

    • Author(s)
      谷口克
    • Organizer
      高知免疫臨床セミナー
    • Place of Presentation
      高知
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NKT細胞—新しい免疫療法の標的

    • Author(s)
      谷口克
    • Organizer
      第11回日本再生医療学会総会 SY-3 アログラフトは再生医療の起爆剤となるか?
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NKT細胞

    • Author(s)
      谷口克
    • Organizer
      日本免疫学会サマースクール2012
    • Place of Presentation
      那須
    • Related Report
      2012 Annual Research Report
  • [Presentation] 花粉症の薬開発最前線

    • Author(s)
      谷口克
    • Organizer
      地球維新塾(塾長 松井孝典)
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん細胞は自己なのに、免疫治療は可能か

    • Author(s)
      谷口克
    • Organizer
      第97回信濃木崎夏期大学講座
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] アレルギーは正常な非自己免疫反応

    • Author(s)
      谷口克
    • Organizer
      第98回信濃木崎夏期大学講座
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] アレルギー治療戦略

    • Author(s)
      谷口克
    • Organizer
      北海道免疫疾患談話会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] NKT細胞-新しい概念に基づく難治性疾患の治療標的-

    • Author(s)
      谷口克
    • Organizer
      筑波大学 - 東京理科大学生命科学研究所合同シンポジウム「難治性免疫疾患・アレルギー疾患の克服をめざして」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] NKT cell subsets

    • Author(s)
      谷口克
    • Organizer
      橋本病百周年記念国際シンポジム
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] NKT cells as an ideal target for anti-tumor immunotherapy

    • Author(s)
      Taniguchi M
    • Organizer
      第41回日本免疫学会総会・学術集会 / 41th Annual Meeting of the Japanese Society for Immunology 講演
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新しい概念に基づくがん治療

    • Author(s)
      谷口克
    • Organizer
      第25回日本バイオセラピー学会ランチョンセミナー
    • Place of Presentation
      倉敷
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 花粉症治療戦略

    • Author(s)
      谷口克
    • Organizer
      花粉問題対策事業者協議会月例会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新しい概念に基づく難治性疾患の治療標的

    • Author(s)
      谷口克
    • Organizer
      全身性炎症疾患の病因・病態の解明に関する研究助成 第2回研究発表会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://web.rcai.riken.jp/en/labo/regulation/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 水酸化KRN7000類縁体及びその用途2013

    • Inventor(s)
      汐崎正生、田代卓哉、森謙治、重浦智邦、渡会浩志、谷口克.
    • Industrial Property Rights Holder
      汐崎正生、田代卓哉、森謙治、重浦智邦、渡会浩志、谷口克.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-08-02
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規カルバメート糖脂質およびその用途2013

    • Inventor(s)
      田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志、(重浦智邦).
    • Industrial Property Rights Holder
      田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志、(重浦智邦).
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-26
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] アレルギー疾患治療薬2013

    • Inventor(s)
      石井保之、田代卓哉、谷口克
    • Industrial Property Rights Holder
      石井保之、田代卓哉、谷口克
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-038047
    • Filing Date
      2013-02-27
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規カルバメート糖脂質の合成およびその用途2012

    • Inventor(s)
      田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志
    • Industrial Property Rights Holder
      田代卓哉、森謙治、汐崎正生、谷口克、渡会浩志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-101384
    • Filing Date
      2012-04-26
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 水酸化KRN7000類縁体及びその用途(水酸化KRN7000類縁体)2012

    • Inventor(s)
      汐崎正生、田代卓哉、森謙治、重浦智邦、渡会浩志、谷口克
    • Industrial Property Rights Holder
      汐崎正生、田代卓哉、森謙治、重浦智邦、渡会浩志、谷口克
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-173278
    • Filing Date
      2012-08-03
    • Related Report
      2012 Annual Research Report

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Published: 2011-06-18   Modified: 2019-07-29  

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