| Budget Amount *help |
¥194,480,000 (Direct Cost: ¥149,600,000、Indirect Cost: ¥44,880,000)
Fiscal Year 2015: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2014: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2013: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2012: ¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2011: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
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| Outline of Final Research Achievements |
We have examined the glial functions in spinal cord dorsal horn in neuropathic pain and obtained the following results. ① We identified activated molecules exclusively expressed in astrocytes using specific transcriptome analysis. ②We found that a transcription factor STAT3 from these molecules is deeply involved in neuropathic pain by behavioral pharmacology analysis. ③ Next, we found that the relationship between STAT3 and microglial activation in the time-course analysis in the neuropathic pain after the nerve injury. ④ In order to elucidate the role in pain transmission in the spinal cord, we established in vivo imaging technology in the spinal cord. ⑤ We examined the expression profile of vesicular nucleotide transporter (VNUT) which is important for ATP release and found that VNUT is tightly involved in neuropathic pain.
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