Neuronal mechanisms for the odor-food association learning and memory consolidation during postprandial sleep

• Project/Area Number: 23240046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: MORI Kensaku 東京大学, 医学(系)研究科(研究院), 教授 (60008563)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000); Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: 嗅覚 / 記憶の固定化 / 摂食 / 睡眠

Outline of Final Research Achievements

1) We found that tufted cell pathway and mitral cell pathway convey odor signals at different time windows of a respiration cycle and to different targets in the olfactory cortex. 2) We found that specific domains of the olfactory tubercle represent learned odor-induced specific motivated behaviors. 3) We found that enhanced elimination of granule cells occurs in the olfactory bulb during postprandial rest and sleep period and that the sharp wave-associated top-down inputs from the olfactory cortex regulate the elimination of granule cells. 4) We found that during slow wave sleep, coordinated interactions occur among areas of the olfactory cortex and between the olfactory cortex and the orbitofrontal cortex.

Research Products

• [Journal Article] Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons following injury in adult mice. (2015)
  • Author(s): Kikuta S., Sakamoto T, Nagayama S., Kanaya K., Kinoshita M, Kondo K., Tsunoda, K., Mori, K. and Yamasoba T.
  • Journal Title: J. Neuroscience Volume: 35 Pages: 2657-2673
  • Peer Reviewed
• [Journal Article] Netrin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb (2015)
  • Author(s): Inoue, T., Fukunaga, T., Rikitake, Y., Maruo, T., Mandai, K., Kimura, K., Kayahara, T., Wang, S., Ito, Y., Sai, K., Mori, M., Mori K., Mizoguchi A. and Takai, Y.
  • Journal Title: J. Comp. Neurol. Volume: in press
• [Journal Article] Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning (2014)
  • Author(s): Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R. and Imayoshi, I.
  • Journal Title: J. Neuroscience Volume: 34 Issue: 17 Pages: 5788-5799
  • DOI: 10.1523/jneurosci.0674-14.2014
  • Peer Reviewed
• [Journal Article] Critical periods in adult neurogenesis and possible clinical utilization of new neurons. (2014)
  • Author(s): Yamaguti, M. and Mori, K
  • Journal Title: Frontiers in Neuroscience Volume: 8 Pages: 1-3
  • DOI: 10.3389/fnins.2014.00177
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb (2014)
  • Author(s): Komano-Inoue S., Manabe H. Ota, M. Kusumoto-Yoshida I., Yokoyama T, Mori, K. and Yamaguchi M.
  • Journal Title: Eur. J. Neurosci. Volume: 40 Issue: 5 Pages: 2724-2733
  • DOI: 10.1111/ejn.12679
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Possible functional role of olfactory subsystems in monitoring inhalation and exhalation. (2014)
  • Author(s): Mori K., Manabe H., and Narikiyo K.
  • Journal Title: Frontiers in Neuroanatomy Volume: 8 Pages: 1-3
  • DOI: 10.3389/fnana.2014.00107
  • Peer Reviewed / Open Access
• [Journal Article] Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle neurons during slow wave sleep (2014)
  • Author(s): Narikiyo K, Manabe H, and Mori K
  • Journal Title: J Neurophysiol Volume: 111 Issue: 1 Pages: 72-81
  • DOI: 10.1152/jn.00535.2013
  • Peer Reviewed
• [Journal Article] Sniff rhythm-paced fast and slow gamma oscillations in the olfactory bulb: relation to tufted and mitral cells and behavioral states. (2013)
  • Author(s): Manabe H, Mori K
  • Journal Title: J Neurophysiol Volume: 110 Issue: 7 Pages: 1593-1599
  • DOI: 10.1152/jn.00379.2013
  • Peer Reviewed
• [Journal Article] Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex and orbitofrontal cortex. (2013)
  • Author(s): Mori K, Manabe H, Narikiyo K, Onisawa N
  • Journal Title: Frontiers in Psychology Volume: 4 Pages: 743-743
  • DOI: 10.3389/fpsyg.2013.00743
  • Peer Reviewed
• [Journal Article] Reorganization of neuronal circuits of the central olfactory system during postprandial sleep (2013)
  • Author(s): Yamaguchi M, Manabe H, Murata K, and Mori K
  • Journal Title: Frontiers in neural Circuits Volume: 7 Pages: 132-132
  • DOI: 10.3389/fncir.2013.00132
  • Peer Reviewed
• [Journal Article] Parallel Mitral and Tufted Cell Pathways Route Distinct Odor Information to Different Targets in the Olfactory Cortex (2012)
  • Author(s): Kei Igarashi, Nao Ieki
  • Journal Title: Journal of Neuroscience Volume: 32 Issue: 23 Pages: 7970-7985
  • DOI: 10.1523/jneurosci.0154-12.2012
  • Peer Reviewed
• [Journal Article] Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. (2012)
  • Author(s): Muzuguchi, R., Naritsuka, H., Mori, K, and Yoshihara, Y.
  • Journal Title: J. Neurosci. Volume: 32 Issue: 26 Pages: 8831-8844
  • DOI: 10.1523/jneurosci.5746-11.2012
  • Peer Reviewed
• [Journal Article] Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. (2012)
  • Author(s): Furutani, Y., Kawasaki, M., Matsuno, H., Mitsui, S., Mori, K. and Yoshihara, Y.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 46 Pages: 39041-3904
  • DOI: 10.1074/jbc.m112.383851
  • Peer Reviewed
• [Journal Article] Dried-bonito aroma components enhance salivary hemodynamic responses to broth tastes detected by near-infrared spectroscopy. (2012)
  • Author(s): Matsumoto, T., Saito, K., Nakamura, A., Saito, T., Nammoku T., Ishikawa, M., and Mori, K.
  • Journal Title: J. Agric Food Chemistry Volume: 60 Issue: 3 Pages: 805-811
  • DOI: 10.1021/jf203725r
  • Peer Reviewed
• [Journal Article] 5T4 Glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb (2012)
  • Author(s): Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern P. L. and Tsuboi A
  • Journal Title: The Journal of Neuroscience Volume: Vol.32 Issue: 6 Pages: 2217-2226
  • DOI: 10.1523/jneurosci.5907-11.2012
  • Peer Reviewed
• [Journal Article] Olfactory cortex generates synchronized top-down inputs to the olfactory bulb during slow-wave sleep (2011)
  • Author(s): Manabe, H., et al.
  • Journal Title: J.Neuroscience Volume: 31(22) Issue: 22 Pages: 8123-8133
  • DOI: 10.1523/jneurosci.6578-10.2011
  • Peer Reviewed
• [Journal Article] Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period. (2011)
  • Author(s): Yokoyama, T.K., et al.
  • Journal Title: Neuron Volume: 71 Issue: 5 Pages: 883-897
  • DOI: 10.1016/j.neuron.2011.05.046
  • Peer Reviewed
• [Journal Article] How is the olfactory map formed and interpreted in the mammalian brain? (2011)
  • Author(s): Mori, K. and Sakano, H.
  • Journal Title: Ann. Rev. Neurosci. Volume: 34 Issue: 1 Pages: 465-499
  • DOI: 10.1146/annurev-neuro-112210-112917
  • Peer Reviewed
• [Journal Article] Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb (2011)
  • Author(s): Koshi Murata, Maki Imai, Shigetada Nakanishi, Dai Watanabe, Ira Pastan, Kazuto Kobayashi, Tomoko Nihira, Hideki Mochizuki, Shuichi Yamada, Kensaku Mori, Masahiro Yamaguchi
  • Journal Title: The Journal of Neuroscience Volume: 31 Issue: 29 Pages: 10540-10557
  • DOI: 10.1523/jneurosci.1285-11.2011
  • Peer Reviewed
• [Journal Article] Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes differently respond to phenyl ethers (2011)
  • Author(s): Tsuboi, A., et al.
  • Journal Title: European Journal of Neuroscience Volume: 33(2) Pages: 205-213
  • Peer Reviewed
• [Journal Article] Genetic visualization of the secondary olfactory pathway in TbX21 transgenic mice (2011)
  • Author(s): Mitsui S, et al
  • Journal Title: Neural Systems & Circuits Volume: 1 Issue: 1 Pages: 1-5
  • DOI: 10.1186/2042-1001-1-5
  • Peer Reviewed
• [Journal Article] Continuous neurogenesis in the adult forebrain is required for innate olfactory responses (2011)
  • Author(s): M.Sakamoto, I.Imayoshi, T.Ohtsuka, M.Yamaguchi, K.Mori, R.Kageyama
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 108 Issue: 20 Pages: 8479-8484
  • DOI: 10.1073/pnas.1018782108
  • Peer Reviewed
• [Presentation] Respiration rhythm and olfaction (2015)
  • Author(s): 森 憲作
  • Organizer: 第９２回日本生理学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-03-21
• [Presentation] Breath rhythm and olfaction (2014)
  • Author(s): Mori, K.
  • Organizer: Center for Functional Connections Seminar
  • Place of Presentation: Korea Institute of Science and Technology（ソウル、韓国)
  • Year and Date: 2014-12-03
• [Presentation] Distinct functional roles of tufted cell and mitral cell inputs in odor information processing in the olfactory cortex (2013)
  • Author(s): Mori, K
  • Organizer: ECRO2013 (European Chemoreception Research Organization)
  • Place of Presentation: Leuven (Belgium)
  • Invited
• [Presentation] Participation of top-down inputs from the olfactory cortex to the olfactory bulb in the enhanced elimination of granule cells during postprandial sleep period (2013)
  • Author(s): 駒野-井上 清香，眞部 寛之，太田 瑞穂，楠本-吉田 郁恵，横山 健，森 憲作，山口 正洋
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Coordinated activity of anterior piriform cortex and orbitofrontal cortex during slow-wave sleep (2013)
  • Author(s): Naomi Onisawa, Hiroyuki Manabe, and Kensaku Mori
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Synapse formation of adult-born granule cells at distinct subcellular domains of projection neurons in the mouse olfactory bulb (2013)
  • Author(s): Hiromi Naritsuka, Kensaku Mori, Masahiro Yamaguchi
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Participation of synchronized top-down inputs from the anterior piriform cortex to the olfactory bulb in the enhanced elimination of granule cells during postprandial period (2013)
  • Author(s): Sayaka Komano-Inoue, Hiroyuki Manabe, Mizuho Ota, Ikue Kusumoto-Yoshida, Takeshi K Yokoyama, Kensaku Mori, Masahiro Yamaguchi
  • Organizer: Society for Neuroscience annual meeting (Neuroscience 2013)
  • Place of Presentation: San Diego(USA)
• [Presentation] Behavioral state regulates the generation of respiration rhythm-paced fast and slow gamma oscillations in the rat olfactory bulb (2013)
  • Author(s): Hiroyuki Manabe, Naomi Onisawa, Kimiya Narikiyo and Kensaku Mori
  • Organizer: Society for Neuroscience annual meeting (Neuroscience 2013)
  • Place of Presentation: San Diego(USA)
• [Presentation] Synchronized inputs from the piriform cortex activate olfactory tubercle neurons during slow-wave sleep (2012)
  • Author(s): Narikiyo, K., Manabe, H., Mori, K.
  • Organizer: The 10th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Olfactory Cortex sharp wave drives synchronized discharges of olfactory tubercle neurons during slow-wave sleep (2012)
  • Author(s): Narikiyo, K., Manabe, H., Mori, K.
  • Organizer: The 42nd annual meeting of Society for Neuroscience 2012
  • Place of Presentation: New Orleans (USA)
• [Presentation] Sensory experience-dependent reorganization of neuronal circuits in the olfactory cortex and olfactory bulb (2011)
  • Author(s): Mori, K.
  • Organizer: IIAS Research Conference 2011
  • Place of Presentation: 国際高等研究所(京都府)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Olfactory cortex sharp waves are associated with synchronized synaptic inputs to pyramidal cells in the rat olfactory cortex during slow wave sleep-like state (2011)
  • Author(s): Kashiwadani, H., Mori, K
  • Organizer: Society for Neuroscience 41^<st> annual meeting
  • Place of Presentation: Washington Convention Center (Washington DC、USA)
  • Year and Date: 2011-11-15
• [Presentation] Synchronized top-down inputs from the olfactory cortex during postprandial sleep participate in the enhanced cell death of adult-born granule cells in the olfactory bulb (2011)
  • Author(s): Komano, S., et al.
  • Organizer: Society for Neuroscience 41^<st> annual meeting
  • Place of Presentation: Washington Convention Center (Washington DC, USA)
  • Year and Date: 2011-11-13
• [Presentation] Compensation of depleted granule cell subtypes by newborn neurons in a local area of the adult mouse olfactory bulb (2011)
  • Author(s): Murata, K., et al.
  • Organizer: The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2011-11-05
• [Presentation] 脳の嗅覚神経系研究の最近の進歩 (2011)
  • Author(s): 森憲作
  • Organizer: 日本味と匂い学会
  • Place of Presentation: 金沢音楽堂(石川県)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] 感覚入力依存的な嗅球介在ニューロンの樹状突起の発達機構 (2011)
  • Author(s): 坪井昭夫, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] 嗅球新生顆粒細胞の細胞死における嗅皮質からの同期したトップダウン入力の役割 (2011)
  • Author(s): 駒野清香, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] マウス嗅球の僧帽細胞と房飾細胞では匂い応答閾値と応答の時間的特性が異なる (2011)
  • Author(s): 家城直, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Tbx21遺伝子エンハンサーを用いたマウス二次嗅覚経路の可視化と神経活動イメージング (2011)
  • Author(s): 三津井五智子, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] 嗅皮質鋭波と同期した嗅皮質ニューロンの活動とその発生メカニズム (2011)
  • Author(s): 柏谷英樹, 森憲作
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] 嗅球投射ニューロンの異なる細胞領域に対する新生顆粒細胞のシナプス (2011)
  • Author(s): 成塚裕美, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] 成体脳におけるニューロン新生は性特異的行動に必須である (2011)
  • Author(s): 坂本雅之, 他
  • Organizer: 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Information processing rhythms in neuronal circuits of the olfactory system.
  • Author(s): Mori, K
  • Organizer: RIKEN BSI Seminar Series
  • Place of Presentation: 和光市（埼玉）
  • Invited
• [Presentation] 匂い情報とモチベーション行動反応
  • Author(s): 森 憲作
  • Organizer: 嗅覚情報処理の神経基盤ワークショップ
  • Place of Presentation: 東京大学
  • Invited
• [Presentation] 食後睡眠中の嗅覚神経系再編
  • Author(s): 森 憲作
  • Organizer: 第２回睡眠研究会
  • Place of Presentation: 名古屋大学
  • Invited
• [Presentation] 食べ物の香り受容と情動行動への変換の脳神経メカニズム
  • Author(s): 森 憲作
  • Organizer: 第２７回日本香辛料研究科会
  • Place of Presentation: 日本大学 （神奈川）
  • Invited
• [Presentation] Neuronal cuicuits in the olfactory system. From odor information to motivational behaviors
  • Author(s): Mori, K.
  • Organizer: International Symposium at CAS Ludwig-Maximilians University Munich.
  • Place of Presentation: Munich (Germany)
  • Invited
• [Presentation] Olfactory information processing streams from olfactory bulb to olfactpory cortex and beyond
  • Author(s): Mori, K.
  • Organizer: International Symposium on Sensory Systems & Neural Circuits
  • Place of Presentation: 東京大学
  • Invited
• [Presentation] Distinct subregions of olfactory tubercle respond to odors associated with different motivation
  • Author(s): Murata, K., Kanno, M., Ieki, N., Mori, K. & Yamaguchi, M.
  • Organizer: International Symposium on Sensory Systems & Neural Circuits
  • Place of Presentation: 東京大学
• [Presentation] The olfactory tubercle receives highly synchronized inputs from the piriform cortex during slow-wave sleep
  • Author(s): Narikiyo, K., Manabe, H., Mori, K.
  • Organizer: International Symposium on Sensory Systems & Neural Circuits
  • Place of Presentation: 東京大学
• [Presentation] Synapse formation of adult-born granule cells at distinct subcellular domains of projection neurons in the mouse olfactory bulb
  • Author(s): Naritsuka, H., Mori, K., & Yamaguchi, M.
  • Organizer: International Symposium on Sensory Systems & Neural Circuits
  • Place of Presentation: 東京大学
• [Presentation] 嗅球顆粒細胞の細胞死を嗅皮質からの同期したトップダウン入力が制御する
  • Author(s): 駒野清香、眞部寛之、太田瑞穂、楠本ー吉田郁恵、横山健、森憲作、山口正洋
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 徐波睡眠時における嗅皮質および島皮質間の相互作用
  • Author(s): 鬼沢菜穂美、眞部寛之、森憲作
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] マウス嗅球において投射ニューロンの異なる細胞領域に形成される新生顆粒細胞からのシナプス
  • Author(s): 成塚裕美、森憲作、山口正洋
  • Organizer: 第３５回日本神経科学大会
  • Place of Presentation: 名古屋
• [Book] The Olfactory System (2014)
  • Author(s): Kensaku Mori (Editor)
  • Total Pages: 206
  • Publisher: Springer
• [Remarks] 東京大学 医学系研究科 細胞分子生理学教室
  • URL: http://morilab.m.u-tokyo.ac.jp
• [Remarks] 東京大学 大学院医学系研究科 機能生物学専攻 細胞分子生理学教室
  • URL: http://morilab.m.u-tokyo.ac.jp
• [Remarks]
  • URL: http://morilab.m.u-tokyo.ac.jp//