Molecular mechanisms of pathological protein propagation and its regulation

• Project/Area Number: 23240050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HASEGAWA Masato 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 分野長 (10251232)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000); Fiscal Year 2013: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000); Fiscal Year 2012: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000); Fiscal Year 2011: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
• Keywords: 神経変性疾患 / 伝播 / シヌクレイン / TDP-43 / タウ / プリオン / αシヌクレイン

Research Abstract

Progressive neurodegeneration with accumulation of abnormal proteins is the defining neuropathological feature of many neurodegenerative diseases, including Lewy body disease (LBD) and ALS/FTLD. We revealed that injections of recombinant alpha-synuclein (aS) fibrils efficiently induced hyperphosphorylated aS pathology in wild-type mice. Biochemical analyses demonstrated that endogenous mouse aS started to accumulate 3 months after inoculation. Furthermore, injections of Sarkosyl-insoluble aS from LBD patients induced similar aS pathology, indicating that aS fibrils show prion-like infectivity. We also demonstrated that insoluble TDP-43 has prion-like properties. These results indicate that pathological proteins may play a role in the progression of neurodegenerative diseases with protein pathologies. These cellular and mouse models should be useful for elucidating progression mechanisms and evaluating disease-modifying therapy.

Research Products

• [Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease (2014)
  • Author(s): Hasegawa M, Watanabe S, Kondo H, Akiyama H, Mann DMA, Saito Y and Murayama S
  • Journal Title: Acta Neuropathol Volume: 127(2) Pages: 303-5
  • Peer Reviewed
• [Journal Article] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease. (2014)
  • Author(s): Hasegawa, M., S. Watanabe, H. Kondo, H. Akiyama, D. M. Mann, Y. Saito and S. Murayama
  • Journal Title: Acta Neuropathol Volume: 127 Issue: 2 Pages: 303-305
  • DOI: 10.1007/s00401-013-1191-9
  • Peer Reviewed
• [Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid. (2014)
  • Author(s): Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H.
  • Journal Title: Int. J. Neurosci. Volume: 124 Issue: 5 Pages: 344-349
  • DOI: 10.3109/00207454.2013.848440
  • Peer Reviewed
• [Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa
  • Journal Title: Cell Rep Volume: 4(1) Pages: 124-34
  • Peer Reviewed
• [Journal Article] Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9ORF72 (2013)
  • Author(s): Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda- Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S
  • Journal Title: Acta Neuropathol. Commun Volume: 1 (1) Pages: 68-68
  • Peer Reviewed
• [Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain (2013)
  • Author(s): Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M
  • Journal Title: Acta Neuropathol. Commun Volume: 1 (1) Pages: 54-54
  • Peer Reviewed
• [Journal Article] Prion-like spreading of pathological alpha-synuclein in brain (2013)
  • Author(s): Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
  • Journal Title: Brain Volume: 136 (Pt 4) Pages: 1128-38
  • Peer Reviewed
• [Journal Article] Pin1 stimulates dephosphorylation of tau at Cdk5- dependent Alzheimer phosphorylation sites (2013)
  • Author(s): Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda-Suzukake M, Ishiguro K, Plattner F, Uchida T, Ishobe T, Hasegawa M, Hisanaga SI
  • Journal Title: J. Biol. Chem Volume: 288(11) Pages: 7968-77
  • Peer Reviewed
• [Journal Article] A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson's disease (2013)
  • Author(s): Foulds PG, Diggle P, Mitchell D, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DMA, Allsop D
  • Journal Title: Sci. Rep Volume: 3 Pages: 2540-2540
  • Peer Reviewed
• [Journal Article] Prion-like spreading of pathological alpha-synuclein in brain. (2013)
  • Author(s): Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
  • Journal Title: Brain Volume: 136 Issue: 4 Pages: 1128-38
  • DOI: 10.1093/brain/awt037
  • Peer Reviewed
• [Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains. (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
  • Journal Title: Cell Rep. Volume: 4 Issue: 1 Pages: 124-34
  • DOI: 10.1016/j.celrep.2013.06.007
  • Peer Reviewed
• [Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain. (2013)
  • Author(s): Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M.
  • Journal Title: Acta Neuropathol. Commun. Volume: 1 Issue: 1 Pages: 54-54
  • DOI: 10.1186/2051-5960-1-54
  • Peer Reviewed
• [Journal Article] Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9ORF72. (2013)
  • Author(s): Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S.
  • Journal Title: Acta Neuropathol. Commun. Volume: 1 Issue: 1 Pages: 68-68
  • DOI: 10.1186/2051-5960-1-68
  • Peer Reviewed
• [Journal Article] Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. (2013)
  • Author(s): Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR.
  • Journal Title: PLoS One Volume: 8 Issue: 6 Pages: e67433-e67433
  • DOI: 10.1371/journal.pone.0067433
  • Peer Reviewed
• [Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases. (2013)
  • Author(s): Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
  • Journal Title: Neurol. Sci. Volume: 335 Issue: 1-2 Pages: 89-95
  • DOI: 10.1016/j.jns.2013.08.035
  • Peer Reviewed
• [Journal Article] A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson’s disease. (2013)
  • Author(s): Foulds PG, Diggle P, Mitchell D, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DMA, Allsop D.
  • Journal Title: Sci. Rep. Volume: 3 Issue: 1 Pages: 2540-2540
  • DOI: 10.1038/srep02540
  • Peer Reviewed
• [Journal Article] Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites (2013)
  • Author(s): Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, and Shin-ichi Hisanaga
  • Journal Title: THE JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 288 Issue: 11 Pages: 7968-7977
  • DOI: 10.1074/jbc.m112.433326
  • Peer Reviewed
• [Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, andCBS (2013)
  • Author(s): Ogaki K
  • Journal Title: Parkinsonism & Related Disorders Volume: 19 Issue: 1 Pages: 15-20
  • DOI: 10.1016/j.parkreldis.2012.06.019
  • Peer Reviewed
• [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy (2012)
  • Author(s): Tsuji1 H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, Hosokawa M, Yoshida M, Hatsuta H, Takao M, Saito Y, Murayama M, Akiyama H, Hasegawa M, Mann DMA, Tamaoka A
  • Journal Title: Brain Volume: 135 Pages: 3380-3391
  • Peer Reviewed
• [Journal Article] Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration (2012)
  • Author(s): Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann DM, Tamaoka A and Hasegawa M
  • Journal Title: Biochem Biophys Res Commun Volume: 417 Pages: 116-121
  • Peer Reviewed
• [Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice. (2012)
  • Author(s): Hosokawa M
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e52389-e52389
  • DOI: 10.1371/journal.pone.0052389
  • Peer Reviewed
• [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy (2012)
  • Author(s): Tsuji H
  • Journal Title: Brain Volume: 135(11) Issue: 11 Pages: 3380-91
  • DOI: 10.1093/brain/aws230
  • Peer Reviewed
• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells (2012)
  • Author(s): Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
  • Journal Title: Sci. Transl. Med. Volume: 4 Issue: 145 Pages: 1-8
  • DOI: 10.1126/scitranslmed.3004052
  • Peer Reviewed
• [Journal Article] Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes. (2012)
  • Author(s): Parker SJ
  • Journal Title: PLoS One Volume: 7 Issue: 8 Pages: e42277-e42277
  • DOI: 10.1371/journal.pone.0042277
  • Peer Reviewed
• [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan. (2012)
  • Author(s): Kokubo Y
  • Journal Title: J Neuropathol Exp Neurol Volume: 71(7) Issue: 7 Pages: 625-630
  • DOI: 10.1097/nen.0b013e31825b9680
  • Peer Reviewed
• [Journal Article] Phosphorylated a-Synuclein in Parkinson’s Disease. (2012)
  • Author(s): Wang Y
  • Journal Title: Sci Transl Med Volume: 4 Issue: 121
  • DOI: 10.1126/scitranslmed.3002566
  • Peer Reviewed
• [Journal Article] Regulation of mitochondrial transport and inter-microtubule spacing by Tau‥ (2012)
  • Author(s): Shahpasand, et al
  • Journal Title: J Neurosci Volume: 32 Issue: 7 Pages: 2430-41
  • DOI: 10.1523/jneurosci.5927-11.2012
  • Peer Reviewed
• [Journal Article] Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies. (2012)
  • Author(s): Iguchi Y,Katsuno M,Takagi S.Ishigaki S,Niwa JI,Hasegawa M,Tanaka F,Sobue G
  • Journal Title: Neurobiol Dis Volume: 45 Issue: 3 Pages: 862-870
  • DOI: 10.1016/j.nbd.2011.12.002
  • Peer Reviewed
• [Journal Article] Post mortem cerebrospinal fluidα-synuclein levels are raised in multiple system atrophy and distinguish this from the otherα-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies (2012)
  • Author(s): Foulds PG, Yokota O, Thurston A, Davidson Y, Ahmed Z, Holton J, Thompson JC, Akiyama H, Arai T, Hasegawa M, Gerhard A, Allsop D, Mann DM
  • Journal Title: Neurobiol Dis Volume: 45 Issue: 1 Pages: 188-95
  • DOI: 10.1016/j.nbd.2011.08.003
  • Peer Reviewed
• [Journal Article] Molecular Dissection of TDP-43 Proteinopathies (2011)
  • Author(s): Hasegawa M, Nonaka T, Tsuji H, Tamaoka A, Yamashita M, Kametani F, Yoshida M, Arai T, Akiyama H
  • Journal Title: J Mol Neurosci Volume: 45 Pages: 480-485
  • Peer Reviewed
• [Journal Article] Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration (2011)
  • Author(s): Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann D. M. A., Tamaoka A, Hasegawa M
  • Journal Title: Biochem Biophys Res Commun Volume: 417 Issue: 1 Pages: 116-121
  • DOI: 10.1016/j.bbrc.2011.11.066
  • Peer Reviewed
• [Journal Article] C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced‥ (2011)
  • Author(s): Meyerowitz, et al
  • Journal Title: Mol Neurodegeneration Volume: 6 Issue: 1 Pages: 57-57
  • DOI: 10.1186/1750-1326-6-57
  • Peer Reviewed
• [Journal Article] Phosphorylated alpha-synuclein can be detected in blood plasma‥ (2011)
  • Author(s): Foulds, et al
  • Journal Title: FASEB J Volume: 25 Issue: 12 Pages: 4127-37
  • DOI: 10.1096/fj.10-179192
  • Peer Reviewed
• [Journal Article] In vitro recapitulation of aberrant protein inclusions in neurodegenerative diseases… (2011)
  • Author(s): Nonaka T, Hasegawa M
  • Journal Title: Integ Biol Volume: 4 Pages: 501-502
  • Peer Reviewed
• [Journal Article] Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy (2011)
  • Author(s): Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
  • Journal Title: J Neurol Sci Volume: 301 Issue: 1-2 Pages: 77-85
  • DOI: 10.1016/j.jns.2010.10.021
  • Peer Reviewed
• [Journal Article] 病理構造物の解析からみちびかれた精神神経疾患の新しい考え方 (2011)
  • Author(s): 長谷川成人, 他
  • Journal Title: 精神医学 Volume: 53 Pages: 1201-1206
  • Peer Reviewed
• [Presentation] 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease. International symposium (2014)
  • Author(s): Hasegawa M, Dan A, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S
  • Organizer: New Frontier of Molecular Neuropathology 2014
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-03-17
• [Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H and Hasegawa M
  • Organizer: Alzheimer's Association International Conference (AAIC2013)
  • Place of Presentation: Boston, USA
  • Year and Date: 2013-07-18
• [Presentation] Prion-like spreading of pathological alpha-synuclein in brain (2013)
  • Author(s): Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H and Hasegawa M
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Florence, Italy
  • Year and Date: 2013-03-09
• [Presentation] Prion-like properties of pathological TDP-43 aggregates in diseased brains (2013)
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Yoshida M, Murayama S, Mann D, Akiyama H and Hasegawa M
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Florence, Italy
  • Year and Date: 2013-03-07
• [Presentation] 「蛋白癌」としてのアルツハイマー病 (2012)
  • Author(s): 長谷川成人
  • Organizer: 北海道大学薬学部・大学院薬学研究院神経病理・病態生化学(IBL)シンポジウム
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2012-02-23
• [Presentation] 異常タンパク分子から解明される神経変性疾患の新しい考え方 (2012)
  • Author(s): 長谷川成人
  • Organizer: 首都大学東京CRESTシンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-02-03
• [Presentation] Prion-like Spreading of Pathological a-synuclein in Brain. (2012)
  • Author(s): Hasegawa M
  • Organizer: The 17th Takeda Science Foundation Symposium
  • Place of Presentation: 大阪
  • Invited
• [Presentation] レビー小体とαシヌクレイン (2012)
  • Author(s): 長谷川成人
  • Organizer: 第６回 レビー小体型認知症研究会 (レビー小体発見１００周年記念大会)
  • Place of Presentation: 東京
  • Invited
• [Presentation] TDP-43と関連疾患 (2012)
  • Author(s): 長谷川成人
  • Organizer: 第３１回 日本認知症学会学術集会 教育講演２「病因仮説再考」
  • Place of Presentation: 筑波
  • Invited
• [Presentation] 蓄積タンパク質の解析から発症機構の解明、治療法の開発へ (2012)
  • Author(s): 長谷川成人
  • Organizer: 第7回 精神医療セミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] 神経変性疾患の分子病態機序 (2012)
  • Author(s): 長谷川成人
  • Organizer: 日本食品免疫学会2012年度大会 (JAFI2012) 「 シンポジウム１」（
  • Place of Presentation: 東京
  • Invited
• [Presentation] 神経疾患と異常タンパク質 (2012)
  • Author(s): 長谷川成人
  • Organizer: 第13回北海道神経変性疾患治療研究会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 神経疾患における異常タンパク質のプロテオミクス解析 (2012)
  • Author(s): 長谷川成人
  • Organizer: 日本プロテオーム学会2012年大会 シンポジウムS５医学の最前線とプロテオミクス
  • Place of Presentation: 東京
  • Invited
• [Presentation] 神経変性疾患は「蛋白癌」か？ (2012)
  • Author(s): 長谷川成人
  • Organizer: 名古屋大学グローバルCOEプログラム 機能分子医学への神経疾患・腫瘍の融合拠点 グローバルCOE第５回国内シンポジウム
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 筋萎縮性側索硬化症：TDP-43の発見とその後 (2012)
  • Author(s): 長谷川成人
  • Organizer: 第53回神経病理学会総会シンポジウム２
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 蛋白癌」としての神経変性疾患 (2012)
  • Author(s): 長谷川成人
  • Organizer: 第53回神経学会総会シンポジウム: 神経変性疾患の病態解明・その病態とバイオマーカーの開発を目指して
  • Place of Presentation: 東京
  • Invited
• [Presentation] 13.長谷川成人神経変性疾患における異常蛋白蓄積の分子基盤 (2011)
  • Author(s): 長谷川成人
  • Organizer: 第2回神経科学と構造生物学の融合
  • Place of Presentation: 岡崎(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] 細胞内異常蛋白質の伝播の可能性 (2011)
  • Author(s): 長谷川成人, 他
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 神経変性疾患における細胞内異常タンパク質の伝播 (2011)
  • Author(s): 長谷川成人
  • Organizer: 第20回パーキンソン病治療研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] 高齢者ブレインバンクを用いたSeed, aggregation, propagation仮説の検証 (2011)
  • Author(s): 長谷川成人, 他
  • Organizer: 包括脳ネットワーク支援による融合的脳研究の展開
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2011-08-23
• [Presentation] Molecular pathology of TDP-43 proteinopathies (2011)
  • Author(s): Hasegawa M
  • Organizer: 3rd World Congress of Asian Psychiatry 2011
  • Place of Presentation: Melbourne(招待講演)
  • Year and Date: 2011-08-02
• [Presentation] TARDBP/PGRN/VCPとTDP-43:TDP-43発見から5年を経て(蛋白化学の立場から) (2011)
  • Author(s): 長谷川成人
  • Organizer: 神経変性疾患に関する調査研究班平成23年度ワークショップ
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] 神経変性疾患における蛋白癌仮説 (2011)
  • Author(s): 長谷川成人, 他
  • Organizer: 第52回日本神経学会総会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] TDP-43による運動ニューロン変性の分子病態 (2011)
  • Author(s): 野中隆, 長谷川成人
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] 神経変性疾患の蛋白癌仮説 (2011)
  • Author(s): 長谷川成人
  • Organizer: 大阪大学蛋白質研究所セミナー「蛋白質の異常凝集の原理と制御」
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-04-27
• [Presentation] Insoluble TDP-43 prepared from diseased brains has prion-like properties.
  • Author(s): Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann D, Akiyama H and Hasegawa M
  • Organizer: Alzheimer's Association International Conference (AAIC2013)
  • Place of Presentation: Boston, USA
• [Presentation] 3R and 4R tau isoforms in paired helical filaments in Alzheimer’s disease
  • Author(s): Hasegawa M, Dan A, Watanabe S, Kondo H, Akiyama H, Mann DM, Saito Y, Murayama S
  • Organizer: International symposium "New Frontier of Molecular Neuropathology 2014"
  • Place of Presentation: Tokyo, Japan
• [Presentation] 神経変性疾患の原因となるタンパク質の構造異常とその伝播
  • Author(s): 長谷川成人
  • Organizer: 第４回神経科学と構造生物学の融合研究会
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] 神経変性疾患の細胞病理を形成する蛋白質のプリオン様特性
  • Author(s): 長谷川成人
  • Organizer: 第８回臨床ストレス応答学会
  • Place of Presentation: 松本
  • Invited
• [Presentation] 神経変性疾患の分子基盤と進行機序 ―患者脳の解析から導かれた新しい考え方とその検証―
  • Author(s): 長谷川成人
  • Organizer: 平成２５年度文部科学省 新学術領域研究 生命科学系３分野 がん・ゲノム・脳 支援活動合同シンポジウム,
  • Place of Presentation: 東京
  • Invited
• [Presentation] ALS/前頭側頭葉変性症の分子病態機序
  • Author(s): 長谷川成人, 他
  • Organizer: 第28回日本医学会総会2011
  • Place of Presentation: 東京(招待講演)(中止の為オンラインで公開)
• [Book] 細胞内異常タンパク質の伝播の可能性 (2013)
  • Author(s): 長谷川成人
  • Publisher: Dementia Japan
• [Book] 脳内に蓄積したTDP-43 凝集体のプリオン様性質 (2013)
  • Author(s): 野中隆, 長谷川成人
  • Publisher: 細胞工学
• [Book] Braak 仮説をαシヌクレインの細胞間伝播で説明できるか? (2013)
  • Author(s): 長谷川成人
  • Publisher: Frontiers in Parkinson's Disease
• [Book] 細胞内異常タンパク質凝集体の細胞間伝播 : 神経変性疾患の病態進行に関する新たなメカニズム (2013)
  • Author(s): 野中隆, 長谷川成人
  • Publisher: 基礎老化研究
• [Remarks]
  • URL: http://www.igakuken.or.jp/dementia/Neuropathol/toppage.html
• [Remarks] ALS患者脳に出現する原因タンパク質TDP-43の異常凝集物が自身を鋳型として細胞内で増殖,蓄積
  • URL: http://www.igakuken.or.jp/research/topics/2013/0704.html
• [Remarks] 認知症の原因タンパク質が正常タンパク質を異常に変換して 脳内に広がることを実証
  • URL: http://www.metro.tokyo.jp/INET/OSHIRASE/2013/03/20n37300.htm
• [Remarks] 病態細胞生物研究室のホームページをリニューアル
  • URL: http://www.igakuken.or.jp/dementia/Neuropathol/research.html
• [Remarks] 認知症の原因タンパク質が正常タンパク質を異常に変換して脳内に広がることを実証
  • URL: http://www.igakuken.or.jp/research/topics/2013/0307.html
• [Remarks] 難病ＡＬＳや若年性認知症の患者に蓄積する 異常ＴＤＰ-４３の解析、病態を解明
  • URL: http://www.igakuken.or.jp/research/topics/2012/0908.html
• [Patent(Industrial Property Rights)] 新規タウオパチーモデルマウスの作製方法 (2013)
  • Inventor(s): 鈴掛雅美、長谷川成人
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Filing Date: 2013-12-26
  • Overseas
• [Patent(Industrial Property Rights)] 新規タウオパチーモデルマウスの作製方法 (2013)
  • Inventor(s): 鈴掛雅美、長谷川成人
  • Industrial Property Rights Holder: 京都医学総合研究所
  • Filing Date: 2013-12-26
• [Patent(Industrial Property Rights)] 神経変性疾患関連タンパク質の不溶性凝集体の増幅方法 (2011)
  • Inventor(s): 野中隆、増田雅美、山下万喜子、秋山治彦、長谷川成人
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Filing Date: 2011-11-18
  • Overseas
• [Patent(Industrial Property Rights)] 神経変性疾患関連タンパク質の不溶性凝集体の増幅方法 (2011)
  • Inventor(s): 野中隆、増田雅美、山下万喜子、秋山治彦、長谷川成人
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Filing Date: 2011-11-18
• [Patent(Industrial Property Rights)] タンパク質重合体の重合核となりうるタンパク質又はその重合体が導入された細胞及びその製造法 (2011)
  • Inventor(s): 野中隆、渡辺小百合、増田雅美、長谷川成人
  • Industrial Property Rights Holder: 東京都医学総合研究所
  • Acquisition Date: 2011-10-05
  • Overseas