| Budget Amount *help |
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2012: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
It is believed that long-term depression (LTD) is mediated by AMPA receptor endocytosis at the postsynaptic site. During LTD, AMPA receptors are first liberated from their anchoring proteins at the postsynaptic site, diffuse to the perisynaptic site, where endocytosis takes place. However how AMPA receptors are selectively endocytosed remained largely unclear. In addition, it has been a mystery why the delta2 glutamate receptor (GluD2) is crucial for induction of cerebellar LTD. In this study, we found that GluD2 determined whether anchoring proteins were dissociated from AMPA receptors. In addition, we found how clathrin adaptor protein AP-2, an essential molecule for clathrin-dependent endocytosis, accumulated at the perisynaptic site and recognized the AMPA receptor complex during LTD.
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