Comprehensive analysis of human brain network structure based on graph theory using brain MRI
| Project/Area Number |
23240056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional brain recording science
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| Research Institution | Tohoku Pharmaceutical University (2012-2013)
Tohoku University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKI Yasuyuki 東北大学, 加齢医学研究所, 教授 (10375115)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2011: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Keywords | ヒト脳ネットワーク解析 / 脳発達・加齢 / 形態MRI / 拡散テンソル画像 / 機能的MRI / グラフ理論 / small world / 脳MRI / 脳ネットワーク解析 / 子供脳 / 脳発達 / 性差 / 脳画像 / 脳形態計測 / ネットワーク解析 / グラフ情報理論 / 脳加齢 |
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| Outline of Final Research Achievements |
The human brain exhibits a complex network and makes information transmission with high efficiency. We performed network analysis based on graph theory using a large scale brain MRI database of healthy Japanese. The results indicated that subjects from children to older age exhibited a “small-world” property in that they are characterized by highly connected hubs and modularity. Structural brain networks in three age groups (young, middle, old) changed developed into a more distributed organization from young to middle age and then altered greatly, shifting into a more localized organization in old age. The modular organization of brain network was similar between the young and middle age groups, but quite different from the older groups. In particular, the old group showed a notable decrease in the connector ratio and the inter-module connection. Our findings provide quantitative insights into topological principles of brain networks and changes related to normal aging.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children2013
Author(s)
Taki Y, Hashizume H, Thyreau B, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R．
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Journal Title
Human Brain Mapping
Volume: 34
Issue: 8
Pages: 1857-1871
DOI
Related Report
Peer Reviewed
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[Journal Article] Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children2013
Author(s)
Taki Y, Thyreau B, Hashizume H, Sassa Y, Takeuchi H, Wu K, Kotozaki Y, Nouchi R, Asano M, Asano K, Fukuda H, Kawashima R
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Journal Title
Human Brain Mapping
Volume: 34
Issue: 8
Pages: 1842-1856
DOI
Related Report
Peer Reviewed
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