|Budget Amount *help
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2012: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2011: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
|Outline of Final Research Achievements
Estrogen plays a central role in the regulation of social behavior. We aimed to elucidate neurobiological basis of social behavior by focusing on neural mechanisms of 1) sex-specific, 2) time-dependent, and 3) brain site-specific action of estrogen. For this purpose, we performed behavioral, neuroanatomical and molecular biological analyses in global knockout and brain site-specific knockdown mice of two types of estrogen receptors. We have found that estrogen receptor alpha and beta in the medial amygdala, medial preoptic area, hypothalamic ventromedial nucleus, and dorsal raphe nucleus might have differential roles in the regulation of sexual, aggressive behavior and social anxiety levels in male and female mice.