| Budget Amount *help |
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2013: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
The aim of this study was to clear multiple pathogeneses of mitochondrial DNA (mtDNA)-related disorders by using model mice carrying mutant mtDNAs. As results, 1) we succeeded in generating novel model mice carrying mtDNA with a point mutation in tRNA-Lys gene, and the mice expressed myopathy due to the accumulation of mtDNA with a point mutation in tRNA-Lys gene; 2) we showed that mtDNA with a point mutation in ND6 gene was responsible for age-related lymphoma in mice; 3) the diabetic condition was a possible modifier to enhance the pathogenicity of mutant mtDNAs.
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