Therapeutic strategy of drug delivery systems utilizing unique tumor environment
| Project/Area Number |
23240072
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
HASHIDA Mitsuru 京都大学, 薬学研究科(研究院), 教授 (20135594)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Fumiyoshi 京都大学, 薬学研究科, 准教授 (30243041)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Shigeru 長崎大学, 医歯薬学総合研究科, 教授 (20322307)
HIGUCHI Yuriko 京都大学, 健康長寿社会の総合医療開発ユニット, 講師 (40402797)
HASHIDA Yasuhiko 京都大学, 物質-細胞統合システム拠点, 特定研究員 (30512462)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2013: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2011: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
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| Keywords | ドラッグデリバリー / 核酸医療 / がん治療 / 免疫活性化 / 小胞体ストレス / ナノバイオ材料 / 超音波医科学 / がん微小環境 / ナノ粒子 / ターゲティング |
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| Research Abstract |
Cancer cells establish tumor environment that allows them to resist stressful conditions such as low oxygen and low nutrients and escape host immune responses. The present investigation aimed at developing innovative anti-cancer therapeutic systems with paying attention to the unique characteristics of tumorous tissues from those of normal tissues. To achieve this goal, we focused on nucleic acid drugs with high specificity that can break the resistance systems in cancer, and developed effective delivery systems for the drugs to the target by combination of physical and chemical means.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Creation of pure nanodrugs and their anticancer properties2012
Author(s)
H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
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Journal Title
Angew. Chem. Int. Ed
Volume: 51
Issue: 41
Pages: 10315-10318
DOI
Related Report
Peer Reviewed
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[Presentation] New Drug Delivery Systems2012
Author(s)
M. Hashida
Organizer
3rd International Regulatory Workshop on A to Z on Bioequivalence
Place of Presentation
The Hungarian Academy of Sciences, Budapest, Hungary
Related Report
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[Presentation] New Drug Delivery Systems2012
Author(s)
Mitsuru Hashida
Organizer
3rd International Regulatory Workshop on A to Z on Bioequivalence
Place of Presentation
The Hungarian Academy of Sciences (Budapest, Hungary)
Related Report
Invited
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