Development of on-demand multifunctional delivery systems using dendron lipid assemblies
| Project/Area Number |
23240075
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KENJI Kono 大阪府立大学, 工学(系)研究科(研究院), 教授 (90215187)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Ichio (WATARAI Shinobu) 放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
渡来 仁 大阪府立大学, 生命環境科学研究科(系), 准教授 (50175139)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
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| Keywords | 薬物伝達システム / ナノ医療 / 薬物送達システム / がん治療 / ナノバイオ / 薬物送達 / イメージング / 自己組織化 / ワクチン |
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| Research Abstract |
We developed various types of functional dendron-bearing lipids, which include gene delivery dendron lipids, temperature-sensitive dendron lipids, pH-sensitive dendron lipids, and MR imaging dendron lipids. We found that gene delivery dendron lipids achieved highly efficient gene transfection into culture cells through hydrophobic interaction and proton sponge effect. Temperature-dendron lipids were shown to provide a new type of temperature-responsive vesicles that undergo morphology transition at a specific temperature. pH-Sensitive dendron lipids formed highly pH-responsive vesicles with egg yolk phosphatidylcholine that release contents in the endosome of a cell. MR imaging dendron lipids were useful for detection of bio-distribution and accumulation of liposomes, which can lead to personalized chemotherapy. The dendron lipid technology is expected to contribute development of new efficient noninvasive cancer therapy.
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Assemblies of polyamidoamine dendron-bearing lipids with various generations: their morphologies and abilities of gene transfection2013
Author(s)
S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, H. Minematsu, H. Kitagawa, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi
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Journal Title
J. Biomaterials Applications
Volume: 27
Issue: 4
Pages: 445-456
DOI
Related Report
Peer Reviewed
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[Journal Article] Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy2011
Author(s)
K. Kono, S. Nakashima, D. Kokuryo, I.Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka
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Journal Title
Biomaterials
Volume: 32
Pages: 1387-1395
Related Report
Peer Reviewed
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