| Project/Area Number |
23240081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Yo 早稲田大学, 理工学術院, 准教授 (50424817)
SATO Yoshinobu 大阪大学, 医学(系)研究科(研究院), 准教授 (70243219)
HASHIZUME Makoto 九州大学, 医学(系)研究科(研究院), 教授 (90198664)
FUJIE Masakatsu 早稲田大学, 理工学術院, 教授 (20339716)
HOSHI Takeharu 早稲田大学, 理工学術院, 講師 (50535284)
MIYASHITA Tomoyuki 早稲田大学, 理工学術院, 教授 (20329080)
WATANABE Hiroki 早稲田大学, 理工学術院, 助手 (00609266)
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| Project Period (FY) |
2011-05-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2011: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Keywords | 癌凝固メカニズム / 電磁波熱治療 / 生体熱力学 / バイオメカトロニクス / シミュレーション |
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| Research Abstract |
In order to provide the accuracy of radio frequency ablation (RFA) treatment we proposed a RFA supporting treatment system. We mainly focused on the problems of RFA treatment and proposed the solutions such as (1) clarify the mechanism of coagulation in RFA and (2) develop the temperature distribution simulator based coagulation condition. We employed both mechanical method and biology method to make analyze the coagulation condition and evaluate the experimental results. According to the in vitro experiments, we found that the viscoelasticity of tissue in RFA treatment was useful as the index of coagulation condition and modeled the temperature dependence of viscoelasticity. And we used both mechanical method and biology method to derive and evaluate the parameters of ablation condition, which determined the coagulation condition of tissue. We also validated the bio-heat transfer model in RFA and developed the temperature distribution numerical simulator for RFA.
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