Development for radio frequency ablation supporting system appropriate to coagulation area of tumor by clarifying coagulation mechanism
| Project/Area Number |
23240081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Yo 早稲田大学, 理工学術院, 准教授 (50424817)
SATO Yoshinobu 大阪大学, 医学(系)研究科(研究院), 准教授 (70243219)
HASHIZUME Makoto 九州大学, 医学(系)研究科(研究院), 教授 (90198664)
FUJIE Masakatsu 早稲田大学, 理工学術院, 教授 (20339716)
HOSHI Takeharu 早稲田大学, 理工学術院, 講師 (50535284)
MIYASHITA Tomoyuki 早稲田大学, 理工学術院, 教授 (20329080)
WATANABE Hiroki 早稲田大学, 理工学術院, 助手 (00609266)
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| Project Period (FY) |
2011-05-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2011: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Keywords | 癌凝固メカニズム / 電磁波熱治療 / 生体熱力学 / バイオメカトロニクス / シミュレーション |
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| Research Abstract |
In order to provide the accuracy of radio frequency ablation (RFA) treatment we proposed a RFA supporting treatment system. We mainly focused on the problems of RFA treatment and proposed the solutions such as (1) clarify the mechanism of coagulation in RFA and (2) develop the temperature distribution simulator based coagulation condition. We employed both mechanical method and biology method to make analyze the coagulation condition and evaluate the experimental results. According to the in vitro experiments, we found that the viscoelasticity of tissue in RFA treatment was useful as the index of coagulation condition and modeled the temperature dependence of viscoelasticity. And we used both mechanical method and biology method to derive and evaluate the parameters of ablation condition, which determined the coagulation condition of tissue. We also validated the bio-heat transfer model in RFA and developed the temperature distribution numerical simulator for RFA.
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Report
(4 results)
Research Products
(47 results)
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[Presentation] 肝臓癌の熱治療2013
Author(s)
藤江正克
Organizer
臨床熱工学研究会
Place of Presentation
東京都
Year and Date
2013-12-27
Related Report
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[Presentation] A Method for Distinguishing Coagulation Boundary Tmeperature in liver Tissue for RF Ablation2012
Author(s)
XiaoWei Lu, Mariko Tsukune, Nozomu Yamazaki, Hiroki Watanabe, Yo Kobayashi, Tomoyuki Miyashita, Takashi Kakimoto, Hiromasa, Yamashita, Toshio Chiba, Masakatsu G. Fujie
Organizer
The 8th Asian Conference on Computer Aided Surgery (ACCAS 2012)
Place of Presentation
Beijing, China
Related Report
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[Presentation] A Method for Distinguishing Coagulation Boundary Tmeperature in liver Tissue for RF Ablation
Author(s)
XiaoWei Lu, Mariko Tsukune, Nozomu Yamazaki, Hiroki Watanabe, Yo Kobayashi, Tomoyuki Miyashita, Takashi Kakimoto, Hiromasa, Yamashita, Toshio Chiba, Masakatsu G. Fujie
Organizer
The 8th Asian Conference on Computer Aided Surgery (ACCAS 2012)
Place of Presentation
China, Beijing
Related Report
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[Patent(Industrial Property Rights)] 熱伝導率測定システム2013
Inventor(s)
藤江正克,小林洋,山崎望,呂筱薇,磯部 洋佑
Industrial Property Rights Holder
学校法人早稲田大学
Industrial Property Rights Type
特許
Industrial Property Number
2013-266424
Filing Date
2013-12-25
Application Year
2013
Related Report
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[Patent(Industrial Property Rights)] 熱伝導率測定システム2013
Inventor(s)
藤江正克、小林洋、磯部洋佑，山崎望，呂筱薇
Industrial Property Rights Holder
学校法人早稲田大学
Industrial Property Rights Type
特許
Industrial Property Number
2013-266424
Filing Date
2013-12-25
Application Year
2013
Related Report
