| Project/Area Number |
23240084
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
KOHZUKI Masahiro 東北大学, 医学(系)研究科(研究院), 教授 (70234698)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Osamu 東北大学, 大学院医学系研究科, 准教授 (00361072)
MORI Nobuyoshi 東北大学, 大学院医学系研究科, 助教 (50463790)
ITO Sadayoshi 東北大学, 大学院医学系研究科, 教授 (40271613)
SAITO Takao 福岡大学, 医学研究科, 教授 (10125552)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2011: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Keywords | リハビリテーション / 循環器・高血圧 / 腎臓 / 医療・福祉 / 細胞・組織 / 組織・解剖 / 組織・細胞 |
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| Research Abstract |
Effect of exercise training on renal protection was examined, and mechanism was clarified in rats with renal disease. Clinical benefits of exercise training were examined in hemodialysis patients. In rats with chronic renal failure, a combination therapy with exercise training and angiotensin II receptor blocker had renal protective effects, and an alleviation of carbonyl stress might mediate the renal protective effects. In Dahl salt-sensitive rats, exercise training had renal protective effects with an independent manner of systemic blood pressure, and improvement of oxidative stress and nitric oxide system might mediate the renal protective effects. We developed a low-pried, light weight, work load-controllable bicycle ergometer for exercise training in the hemodialysis period, and recognize beneficial effects of physical functions and QOL in hemodialysis patients.
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