Renal rehabilitation: clarification of mechanism of effectiveness and clinical application
| Project/Area Number |
23240084
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
KOHZUKI Masahiro 東北大学, 医学(系)研究科(研究院), 教授 (70234698)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Osamu 東北大学, 大学院医学系研究科, 准教授 (00361072)
MORI Nobuyoshi 東北大学, 大学院医学系研究科, 助教 (50463790)
ITO Sadayoshi 東北大学, 大学院医学系研究科, 教授 (40271613)
SAITO Takao 福岡大学, 医学研究科, 教授 (10125552)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2011: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Keywords | リハビリテーション / 循環器・高血圧 / 腎臓 / 医療・福祉 / 細胞・組織 / 組織・解剖 / 組織・細胞 |
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| Research Abstract |
Effect of exercise training on renal protection was examined, and mechanism was clarified in rats with renal disease. Clinical benefits of exercise training were examined in hemodialysis patients. In rats with chronic renal failure, a combination therapy with exercise training and angiotensin II receptor blocker had renal protective effects, and an alleviation of carbonyl stress might mediate the renal protective effects. In Dahl salt-sensitive rats, exercise training had renal protective effects with an independent manner of systemic blood pressure, and improvement of oxidative stress and nitric oxide system might mediate the renal protective effects. We developed a low-pried, light weight, work load-controllable bicycle ergometer for exercise training in the hemodialysis period, and recognize beneficial effects of physical functions and QOL in hemodialysis patients.
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Report
(4 results)
Research Products
(153 results)
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[Journal Article] Exercise performance after the radiofrquency catheter ablation2013
Author(s)
Mori N, Kashiwazaki N, Ito K, Cho C, Lee G, Jia T, Kim J, Kuwahara M, Yamakoshi S, Xu B, Suzuki F, Takahashi T, Gui P, Fukuda K, Wakayama Y, Nakano M, Kondo M, Yuhi H, Shimokawa, Kohzuki M
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Journal Title
Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine.
Volume: 7
Pages: 280-281
Related Report
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[Journal Article] Effect of cardiac rehabilitation on exercise tolerance, instrumental activities of daily living (IADL) and Quality of Life (QOL) in severe heart failure treated with implantable left ventricular assist device (LVAD)2013
Author(s)
Suzuki F, Ito O, Mori N, Takahashi T, Sakata Y, Nagasaka M, Ebihara S, Nakatomi C, Minamishima D, Nikkuni Y, Akiyama M, Kawamoto S, Saiki Y, Kohzuki M
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Journal Title
Proceedings of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine
Volume: 7
Pages: 141-142
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[Journal Article] 東日本大震災から1年半経過した被災地心リハ施設の現状と問題点（まとめ）2013
Author(s)
上月正博, 坂本圭司, 坪井譲, 福本義弘, 青木竜男, 伊藤健太, 安田聡, 下川宏明, 冨塚玲子, 伊藤修, 海老原覚, 長坂誠, 森信芳, 坂田佳子, 鈴木文歌, 高橋珠緒, 田村由馬, 三浦美佐, 須田千尋
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Journal Title
心臓リハビリテーション
Volume: 18
Pages: 55-57
Related Report
Peer Reviewed
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[Journal Article] 植込み型補助人工心臓（LVAD）を装着した重症心不全への心臓リハビリテーションの効果2013
Author(s)
鈴木文歌, 伊藤 修, 森 信芳, 高橋珠緒，坂田佳子，長坂 誠，海老原覚, 仲冨千瑞, 南島大輔, 新國悦弘, 秋山正年, 川本俊介, 齋木佳克, 上月正博
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Journal Title
運動器リハビリテーション
Volume: 24
Pages: 65-71
NAID
Related Report
Peer Reviewed
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[Journal Article] How did rehabilitation professionals act when faced with the Great East Japan earthquake and disaster? Descriptive epidemiology of disability and an interim report of the relief activities of the ten Rehabilitation-Related Organizations2012
Author(s)
Liu M, Kohzuki M, Hamamura A, Ishikawa M, Saitoh M, Kurihara M, Handa K, Nakamura H, Fukaura J, Kimura R, Ito T, Matsuzaka N
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Journal Title
J Rehabil Med
Volume: 44
Pages: 421-428
Related Report
Peer Reviewed
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[Journal Article] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚 強, 高島健太,坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
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Journal Title
運動療法と物理療法
Volume: 22
Pages: 78-84
NAID
Related Report
Peer Reviewed
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[Journal Article] 5/6腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSFの併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚強, 高島健太, 坂田佳子, 室谷嘉一, 森信芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
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Journal Title
運動療法と物理療法
Volume: 22
Pages: 78-84
NAID
Related Report
Peer Reviewed
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[Presentation] Expression of soluble and full-length (pro)renin receptor by dehydration2012
Author(s)
Tamura Y, Mori N, Ito O, Rong R, Xu B, Kim J, Nakamura T, Hirose T, Takahashi K, Totsune K, Kohzuki M
Organizer
American Heart Association High Blood Pressure Research 2012 Scientific Sessions
Place of Presentation
ワシントンDC、USA
Related Report
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[Presentation] 5/6腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSFの併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚強, 高島健太, 坂田佳子, 室谷嘉一, 森信芳, 長坂誠, 海老原覚, 伊藤修, 上月正博
Organizer
第34回日本高血圧学会
Place of Presentation
宇都宮
Year and Date
2011-10-22
Related Report
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[Presentation] Exercise training increases nitric oxide synthases in the kidney of rats with chronic heart failure2011
Author(s)
Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Rong R, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
Organizer
65th Annual Fall Conference and Scientific Session of the Council for High Blood Pressure Research
Place of Presentation
Orland, USA
Year and Date
2011-09-22
Related Report
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[Presentation] Ebihara S, Ito O, Kohzuki M. Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats2011
Author(s)
Suda T, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M
Organizer
6th World Congress of the International Society of Physical and Rehabilitation Medicine
Place of Presentation
San Juan, Puerto Rico
Year and Date
2011-06-13
Related Report
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[Presentation] Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats2011
Author(s)
Suda T, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M, Ebihara S, Ito O, Kohzuki M
Organizer
6th World Congress of the International Society of Physical and Rehabilitation Medicine
Place of Presentation
米国サンファン市
Year and Date
2011-06-13
Related Report
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[Presentation] 脱水による腎プロレニンレセプターの発現変化
Author(s)
田村由馬, 森 信芳, 徐 斌, 中村貴裕, 金 鍾宇, 戎 栄, 廣瀬卓男, 高橋和広, 戸恒和人, 伊藤 修, 上月正博
Organizer
日本内分泌学会東北地方会
Place of Presentation
仙台市
Related Report
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