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The conprehensive study for the interaction between environmental and genetic factors associated with amount of physical activity of Japanese population

Research Project

Project/Area Number 23240089
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical education
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

MIYACHI Motohiko  独立行政法人国立健康・栄養研究所, 健康増進研究部, 部長 (60229870)

Co-Investigator(Renkei-kenkyūsha) MURAKAMI Haruka  独立行政法人国立健康, 栄養研究所・健康増進研究部, 研究員 (20344880)
SANADA Kiyoshi  立命館大学, スポーツ健康科学部, 教授 (50421227)
IEMITSU Motoyuki  立命館大学, スポーツ健康科学部, 教授 (90375460)
FUKU Noriyuki  順天堂大学, 大学院スポーツ健康科学研究科, 准教授 (40392526)
YASUNAGA Akitomo  文化学園大学, 現代文化学部, 准教授 (30289649)
YANO Hiromi  川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
Research Collaborator KAWAKAMI Ryoko  
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2012: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords身体活動 / 環境 / 遺伝 / 免疫 / 疫学 / 生理学 / 生化学 / 腸内細菌 / 身体活動量 / 遺伝子多型 / 活動強度 / GWAS / 遺伝要因 / 環境要因
Outline of Final Research Achievements

There is large Individual variations in physical activity. This may be associated with differences in the environmental, genetic and trait, and fatigue and infectious factors. Our studies indicated that 1) high-intensity physical activity was associated with a plurality of SNPs in chromosome 4 and 8, 2) mitochondrial DNA polymorphism was associated with the strength and agility, 3) shopping and living environments were associated with walking and physical activity, and 4) the interaction of intestinal immunity and intestinal flora were associated to changes in physical activity. These findings suggest that the variability of physical activity may be affected by some internal and external factors, moreover immunity and infection.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (25 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (10 results) (of which Invited: 4 results) Book (2 results) Remarks (1 results)

  • [Journal Article] "Add 10 min for your health": the new Japanese recommendation for physical activity based on dose-response analysis.2015

    • Author(s)
      Murakami H, Tripette J, Kawakami R, Miyachi M.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 65 Issue: 11 Pages: 1153-1154

    • DOI

      10.1016/j.jacc.2014.10.080

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese.2014

    • Author(s)
      Murakami H, Iemitsu M, Fuku N, Sanada K, Gando Y, Kawakami R, Miyachi M.
    • Journal Title

      Physiol Behav

      Volume: 19 Pages: 199-204

    • DOI

      10.1016/j.physbeh.2014.02.053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exhaustive exercise increases the TNF-α production in response to flagellin via the upregulation of toll-like receptor 5 in the large intestine in mice.2014

    • Author(s)
      Uchida M, Oyanagi E, Kawanishi N, Iemitsu M, Miyachi M, Kremenik MJ, Onodera S, Yano H.
    • Journal Title

      Immunol Lett.

      Volume: 158 Issue: 1-2 Pages: 151-158

    • DOI

      10.1016/j.imlet.2013.12.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.2014

    • Author(s)
      Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A.
    • Journal Title

      Age (Dordr)

      Volume: 36 Issue: 2 Pages: 933-943

    • DOI

      10.1007/s11357-013-9593-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serum interleukin-18 levels are associated with physical activity in Japanese men.2013

    • Author(s)
      Oda K, Miyatake N, Sakano N, Saito T, Miyachi M, Tabata I, Numata T.
    • Journal Title

      PLoS One.

      Volume: 18 Issue: 12 Pages: e81497-e81497

    • DOI

      10.1371/journal.pone.0081497

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of common and rare mitochondrial DNA variants in elite Japanese athletes : a case-control study.2013

    • Author(s)
      Mikami E, Fuku N, Kong QP, Takahashi H, Ohiwa N, Murakami H, Miyachi M, Higuchi M, Tanaka M, Pitsiladis YP, Kawahara T.
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Issue: 12 Pages: 780-787

    • DOI

      10.1038/jhg.2013.102

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells.2013

    • Author(s)
      Uchida M
    • Journal Title

      J Immunol Methods

      Volume: 31 Issue: 1-2 Pages: 61-69

    • DOI

      10.1016/j.jim.2013.04.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher cardiorespiratory fitness attenuates arterial stiffening associated with the Ala54Thr polymorphism in FABP2.2013

    • Author(s)
      Fujie S
    • Journal Title

      Physiol Genomics

      Volume: 45 Pages: 237-242

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of 29C T Polymorphism in the Transforming Growth Factor-β1 Gene with Lean Body Mass in Community-Dwelling Japanese Population2012

    • Author(s)
      Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12 Issue: 2 Pages: 292-297

    • DOI

      10.1111/j.1447-0594.2011.00768.x

    • NAID

      10031147995

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study.2012

    • Author(s)
      Goto A
    • Journal Title

      Cardiovasc Diabetol

      Volume: 11 Issue: 1 Pages: 130-130

    • DOI

      10.1186/1475-2840-11-130

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measures of physical activity and exercise for health promotion by the Ministry of Health, Labour and Welfare2012

    • Author(s)
      Miyachi M
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 467-472

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations among objectively measured physical activity, fasting plasma homocysteine concetration and MTHFR C677T genotype2011

    • Author(s)
      Murakami H, et al
    • Journal Title

      Eur J Appl Physiol

      Volume: 111 Pages: 2997-3005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] GWAS of elite Jamaican, African American and Japanese sprint athletes.2014

    • Author(s)
      Wang G、Padmanabhan S、Miyamoto-Mikami E、Fuku N、Tanaka M、Miyachi M、Murakami H、Cheng YC、Mitchell BD、Austin KG、Pitsiladis YP
    • Organizer
      61st American College of Sports Medicine
    • Place of Presentation
      Orlando, FL. USA
    • Year and Date
      2014-05-29
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of DRD2/ANKK1 genotype on exercise behavior and performance in Japanese athlete and control.2014

    • Author(s)
      Murakami H、Fuku N、Iemitsu M、Sanada K、Kawakami R、Gando Y、Miyachi M
    • Organizer
      61st American College of Sports Medicine
    • Place of Presentation
      Orlando, FL. USA
    • Year and Date
      2014-05-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] NEXISと佐久コホート研究2011

    • Author(s)
      Miyachi M, et al
    • Organizer
      第14回日本運動疫学研究会
    • Place of Presentation
      下関、山口
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome-Wide Association Study of Physical Activity Level for a Year in Japanses Adults2011

    • Author(s)
      Murakami H, et al
    • Organizer
      58th American College of Sports Medicine
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Resistance training and arterial stiffness, Symposium : Resistance training and vascular disease risks2011

    • Author(s)
      Miyachi M, et al
    • Organizer
      58th American College of Sports Medicine
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2011-06-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 健康運動指導分科会シンポジウム生涯を通じた歩行機能の維持をめざして:運動指導者の役割 メタボとロコモを予防する身体活動

    • Author(s)
      宮地元彦
    • Organizer
      第71回日本公衆衛生学会
    • Place of Presentation
      山口市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 身体活動・運動行動と摂食行動の相互作用における摂食行動関連遺伝子の関与

    • Author(s)
      村上晴香
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 健康日本21(第2次)と運動基準・運動指針 シンポジウム④:日本学術会議との共同シンポジウム~新しいエクササイズガイドを考える~

    • Author(s)
      宮地元彦
    • Organizer
      日本臨床スポーツ医学会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチオンセミナー7 新しいエクササイズガイドの方向性~安全で効果的な運動指導と水分補給~

    • Author(s)
      宮地元彦
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] メタボとロコモを予防・改善するための運動・身体活動、サテライトセミナーB、特別講演 健康習慣「一無、二小、三多」多動

    • Author(s)
      宮地元彦
    • Organizer
      第53回日本人間ドック学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 症状別みんなのストレッチ2012

    • Author(s)
      宮地元彦
    • Total Pages
      95
    • Publisher
      小学館
    • Related Report
      2012 Annual Research Report
  • [Book] 中高年者の血圧調整機能と運動・スポーツ2012

    • Author(s)
      宮地元彦
    • Total Pages
      9
    • Publisher
      大修館書店
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www0.nih.go.jp/eiken/programs/program_kenko.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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