|Budget Amount *help
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|Outline of Final Research Achievements
Physical exercise has a powerful impact on the brain as well as muscles. Especially, it is well known that exercise enhances hippocampal neurogenesis and function. Currently, we have demonstrated that mild exercise is enough to enhance hippocampal plasticity. However, the molecular mechanisms of mild exercise enhance hippocampal function is unknown. To address this issue, we examined what factors and pathways regulate the exercise effects. Our results showed that the neurotrophic factor from astrocyte and neurosteroid synthesized in hippocampus regulated the mild exercise-induced neurogenesis. Furthermore, Ingenuity Pathway Analysis algorithms revealed that the mild exercise-influenced genes were principally related to lipid metabolism and protein synthesis. These evidences might serve in further elucidating the mechanism behind mild exercise induced cognitive gain.