The role of HB-EGF in cancer cell proliferation and malignancy
| Project/Area Number |
23240126
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
MEKADA Eisuke 大阪大学, 微生物病研究所, 教授 (20135742)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2013: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2012: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2011: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Keywords | EGFファミリー / 増殖因子 / 増殖抑制 / EGF受容体 / 心臓弁 / EGFリセプター / ＨＢ-ＥＧＦ / ＥＧＦ受容体 |
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| Outline of Final Research Achievements |
We have studied on the role of HB-EGF in cancer cell proliferation and malignancy. In 2011, we have studied the role of HB-EGF expressing at tumor stroma in uterine cervical cancer. We have shown that HB-EGF expressed in stroma and PDGF expressed in cancer cells contribute to the reciprocal interaction of cancer cells with cancer-associated fibroblasts and promote cancer cell proliferation in a paracrine manner, providing an insight for the novel combinatorial therapy. In 2012-2013, we have studied on the molecular mechanism of HB-EGF-inducing growth inhibition. In cardiac valve, HB-EGF inhibits the proliferation of mesenchymal cells. The study indicated that HB-EGF is expressed in cardiac epithelial cells and secreted toward the mesenchymal cells in developing heart valve tissue, where HB-EGF inhibits mesenchymal cell proliferation. P38 MAPK and JNK are involved in this process. Further study may provide a new paradigm for cancer therapy.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.2013
Author(s)
Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
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Journal Title
Biochem Biophys Res Commun.
Volume: 437
Issue: 2
Pages: 185-191
DOI
Related Report
Peer Reviewed
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[Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.2012
Author(s)
Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M., Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T.
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Journal Title
Hepatol Res
Volume: 43
Issue: 4
Pages: 384-393
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.2012
Author(s)
Moribe, H., Konakawa, R., Yoneda, T., Koga, D., Ushiki, T., Nakamura K. and Mekada, E.
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Journal Title
PLoS Genet.
Volume: 8
Issue: 9
Pages: e1002957-e1002957
DOI
Related Report
Peer Reviewed
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