Research Project
Grant-in-Aid for Scientific Research (A)
We have studied on the role of HB-EGF in cancer cell proliferation and malignancy. In 2011, we have studied the role of HB-EGF expressing at tumor stroma in uterine cervical cancer. We have shown that HB-EGF expressed in stroma and PDGF expressed in cancer cells contribute to the reciprocal interaction of cancer cells with cancer-associated fibroblasts and promote cancer cell proliferation in a paracrine manner, providing an insight for the novel combinatorial therapy. In 2012-2013, we have studied on the molecular mechanism of HB-EGF-inducing growth inhibition. In cardiac valve, HB-EGF inhibits the proliferation of mesenchymal cells. The study indicated that HB-EGF is expressed in cardiac epithelial cells and secreted toward the mesenchymal cells in developing heart valve tissue, where HB-EGF inhibits mesenchymal cell proliferation. P38 MAPK and JNK are involved in this process. Further study may provide a new paradigm for cancer therapy.
All 2013 2012 2011 Other
All Journal Article (11 results) (of which Peer Reviewed: 11 results, Open Access: 2 results) Presentation (6 results) (of which Invited: 2 results) Remarks (1 results)
Worm
Volume: 2 Issue: 2 Pages: 23415-23416
10.4161/worm.23415
J Biol Chem.
Volume: 288 Issue: 36 Pages: 26323-26334
10.1074/jbc.m112.439380
Biochem Biophys Res Commun.
Volume: 437 Issue: 2 Pages: 185-191
10.1016/j.bbrc.2013.05.097
J. Control. Release
Volume: 160 Issue: 2 Pages: 274-280
10.1016/j.jconrel.2011.10.010
FEBS Lett 2012
Volume: 586(6) Issue: 6 Pages: 740-6
10.1016/j.febslet.2012.01.031
Hepatol Res
Volume: 43 Issue: 4 Pages: 384-393
10.1111/j.1872-034x.2012.01074.x
10031194550
PLoS Genet.
Volume: 8 Issue: 9 Pages: e1002957-e1002957
10.1371/journal.pgen.1002957
Am J Transl Res.
Volume: 4 Pages: 415-421
Clinical Cancer Res.
Volume: 17 Pages: 6733-6741
Cancer Res.
Volume: 71 Pages: 6633-6664
Cancer Sci.
Volume: 102 Pages: 111-116
http://cell-biology.biken.osaka-u.ac.jp/MekadaLabHP/Home.html