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Direct effect of radiation and chemicals on human tissues and its mechanism

Research Project

Project/Area Number 23241023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research Institution独立行政法人医薬基盤研究所

Principal Investigator

NOMURA Taisei  独立行政法人医薬基盤研究所, 難病・疾患資源研究部, プロジェクトリーダー (90089871)

Co-Investigator(Kenkyū-buntansha) RYO Haruko  独立行政法人医薬基盤研究所, 難病・疾患資源研究部, サブプロジェクトリーダー (90301267)
TODO Takeshi  大阪大学, 医学(系)研究科(研究院), 教授 (90163948)
MURAKAMI Masao  神戸大学, 医学(系)研究科(研究院), 教授 (50210018)
FUJIKAWA Kazuo  近畿大学, 理工学部, 教授 (90247958)
Co-Investigator(Renkei-kenkyūsha) YOSHIDOME Katsuhide  独立行政法人医薬基盤研究所, 客員研究員 (80598813)
NAKAJIMA Hiroo  大阪大学, 医学(系)研究科(研究院), 助教 (20237275)
AKAGI Takashi  神戸大学, 医学(系)研究科(研究院), 研究員 (50500005)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2013: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2011: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Keywords放射線、粒子線、X線 / 化学物質 / ヒト臓器・組織 / Super-SCID / 環境有害物質 / 人体影響 / メカニズム / 感受性 / 放射線、粒子線、X線 / 放射線、X線、粒子線
Outline of Final Research Achievements

Direct effects of radiation and chemicals on cancer and normal tissues were detected using our super-SCID mouse system which maintains human organs/tissues for long period. Dose dependent suppressive effects of X/gamma-rays, neutron, proton, helium and carbon ions on cancer growth were compared, yielding relative biological effectiveness (RBE). RBE was C>>He>X in lung cancer, C>He=X in prostate cancer, C>X in pancreatic cancer, and C>P≧X in all the three cancer tissues. RBE of carbon ion for changes in gene expression was 4.6 in the normal lung tissues, the value being similar to the RBE (approx. 5) of suppressive effects in the lung cancer tissues. RBE of carbon ion for changes of gene expression was also similar to that of neutron (4.2) in the normal thyroid tissues, but affected gene groups were different. Very small doses of TCDD to the transplanted thyroid tissues suppressed thyroid hormone secretion.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (112 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (44 results) (of which Peer Reviewed: 38 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (63 results) (of which Invited: 22 results) Book (5 results)

  • [Journal Article] Histological Evaluation of Human Benign Prostatic Hyperplasia Treated by Dutasteride: A Study by Xenograft Model with Improved Severe Combined Immunodeficient (Super-SCID) Mice.2015

    • Author(s)
      Akira Tsujimura, Shinichiro Fukuhara, Tetsuji Soda, Kentaro Takezawa, Hiroshi Kiuchi, Tetsuya Takao, Yasushi Miyagawa, Norio Nonomura, Shigeki Adachi, Yoriko Tokita, Taisei Nomura.
    • Journal Title

      Urology

      Volume: 85 Issue: 1 Pages: 274.e1-274.e8

    • DOI

      10.1016/j.urology.2014.09.024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of lactobacilli containing glycolipids with the α-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice.2015

    • Author(s)
      Iwamori M, Tanaka K, Adachi S, Aoki D, Nomura T.
    • Journal Title

      J Biochem

      Volume: pii Issue: 1 Pages: 73-82

    • DOI

      10.1093/jb/mvv021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトがん組織等移植SCIDマウスを用いた重粒子線治療の有効性・安全性の研究2015

    • Author(s)
      野村大成、足立成基、梁 治子、坂巻 靖、鳥 正幸、吉留克英、野々村祝夫、古澤佳也、鵜澤玲子
    • Journal Title

      平成26年度放射線医学総合研究所 重粒子線がん治療装置等共同利用研究報告書

      Volume: 26 Pages: 56-58

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2015

    • Author(s)
      Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
    • Journal Title

      PLoS Genetics

      Volume: 11 Issue: 4 Pages: 1-14

    • DOI

      10.1371/journal.pgen.1005065

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.2014

    • Author(s)
      Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Taisei Nomura, Hiroshi Takemori, et al.
    • Journal Title

      Genes

      Volume: 5 Issue: 4 Pages: 1095-1114

    • DOI

      10.3390/genes5041095

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53-Dependent suppression of genome instability in germ cells.2014

    • Author(s)
      Otozai S, Ishikawa-Fujiwara T, Oda S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, Todo T.
    • Journal Title

      Mutat Res,

      Volume: 760 Pages: 24-32

    • DOI

      10.1016/j.mrfmmm.2013.12.004

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock.2014

    • Author(s)
      Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34(24) Issue: 24 Pages: 4464-73

    • DOI

      10.1128/mcb.00711-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of follicle-stimulating hormone receptor function causes masculinization and sippression of ovarian development in genetically female medaka.2014

    • Author(s)
      Murozumi N, Nakashima R, Hirai T, Kamei Y, Ishikawa-Fujiwara T, Todo T, Kitano T.
    • Journal Title

      Endocrinology

      Volume: 155(8) Issue: 8 Pages: 3136-45

    • DOI

      10.1210/en.2013-2060

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Positive Role for PERIOD in Mammalian Circadian Gene Expression.2014

    • Author(s)
      Akashi M, Okamoto A, Tsuchiya Y, Todo T, Nishida E, Node K.
    • Journal Title

      Cell Rep.

      Volume: 7(4) Issue: 4 Pages: 1056-64

    • DOI

      10.1016/j.celrep.2014.03.072

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human papillomavirus and cystic node metastasis in oropharyyngeal cancer and cancer of unknown primary origin.2014

    • Author(s)
      Yasui T, et al.
    • Journal Title

      PLoS One.

      Volume: 9(4) Issue: 4 Pages: e95364-e95364

    • DOI

      10.1371/journal.pone.0095364

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.2014

    • Author(s)
      Goriki, A., Hatanaka, F., Myung J., Kim, J., Yoritaka, T., Tanoue, S., Abe, T., Kiyonari, H., Fujimoto, K., Kato, Y., Todo, T., Matsubara, A., Forger, D. and Takumi, T.
    • Journal Title

      PLoS Biol.

      Volume: 12 Issue: 4 Pages: e1001839-e1001839

    • DOI

      10.1371/journal.pbio.1001839

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan.2014

    • Author(s)
      Nakajima H, et al.
    • Journal Title

      Health Phys.

      Volume: 106(5) Issue: 5 Pages: 565-570

    • DOI

      10.1097/hp.0000000000000020

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.2014

    • Author(s)
      Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
    • Journal Title

      Cancer Sci.

      Volume: 105(4) Issue: 4 Pages: 409-417

    • DOI

      10.1111/cas.12369

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Cryptochrome/Photolyase Family in aquatic organisms.2014

    • Author(s)
      Oliveri P, et al.
    • Journal Title

      Mar Genomics

      Volume: pii: S1874-7787(14) Pages: 22-1

    • DOI

      10.1016/j.margen.2014.02.001

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in bacterial glycolipids as an index of intestinal lactobacilli and epithelial glycolipids in the digestive tracts of mice after administration of penicillin and streptomycin.2013

    • Author(s)
      Masao Iwamori, et al.
    • Journal Title

      Glycoconj J.

      Volume: 30(9) Issue: 9 Pages: 889-897

    • DOI

      10.1007/s10719-013-9494-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of fucosyl GA1 in the digestive tract of immune-deficient scid, nude and IgR (-/-) mice.2013

    • Author(s)
      Masao Iwamori, et al.
    • Journal Title

      J. Biochem.

      Volume: 154(6) Issue: 6 Pages: 541-549

    • DOI

      10.1093/jb/mvt087

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian and Circalunar Clock Interactions in a Marine Annelid.2013

    • Author(s)
      Zantke J, et al.
    • Journal Title

      Cell Rep.

      Volume: 5(1) Issue: 1 Pages: 99-113

    • DOI

      10.1016/j.celrep.2013.08.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid.2013

    • Author(s)
      Hashimoto K, et al.
    • Journal Title

      Mutagenesis.

      Volume: 28(4) Issue: 4 Pages: 457-464

    • DOI

      10.1093/mutage/get021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013

    • Author(s)
      Kadomatsu T, et al.
    • Journal Title

      PloS One

      Volume: 8(2)

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.2013

    • Author(s)
      Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K.
    • Journal Title

      Mol Biol Cell

      Volume: 24(9) Issue: 9 Pages: 1387-1395

    • DOI

      10.1091/mbc.e12-11-0830

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipidsin symbiotic Lactobacillus, Staphylococcus and Streptococcus species.2012

    • Author(s)
      Masao Iwamori, et al.
    • Journal Title

      Glycoconj J

      Volume: 29 Issue: 4 Pages: 199-209

    • DOI

      10.1007/s10719-012-9393-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 宇宙環境の人体影響評価と防護に関する研究;放射線晩発影響の防護。2012

    • Author(s)
      野村大成、他
    • Journal Title

      Space Util. Res.

      Volume: 28 Pages: 126-129

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 安全の哲学【良心・良識】2012

    • Author(s)
      野村大成
    • Journal Title

      「環」

      Volume: 49 Pages: 175-179

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 孫以降の世代にもガンを起こす。2012

    • Author(s)
      野村大成
    • Journal Title

      食品と暮らしの安全

      Volume: 281 Pages: 7-12

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.2012

    • Author(s)
      Takasu NN, et al.
    • Journal Title

      PLoS One

      Volume: 7(11) Issue: 11 Pages: e48892-e48892

    • DOI

      10.1371/journal.pone.0048892

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes)2012

    • Author(s)
      Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, Todo T, Mitani H
    • Journal Title

      Cell Death Dis

      Volume: 3 Issue: 10 Pages: 1-8

    • DOI

      10.1038/cddis.2012.133

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of urinary bladder ConnexTn43 ana tne circadian clock in coordination of diurnal micturition rhythm2012

    • Author(s)
      Negoro H
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 809-809

    • DOI

      10.1038/ncomms1812

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock2012

    • Author(s)
      Yoshimi Uchida, et.al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 11 Pages: 8318-8326

    • DOI

      10.1074/jbc.m111.308908

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis.2012

    • Author(s)
      Terashima K
    • Journal Title

      Radiother Oncol.

      Volume: 103(1) Issue: 1 Pages: 25-31

    • DOI

      10.1016/j.radonc.2011.12.029

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case Of Actute Exacerbation of ldiopathic Pulmonary Fibrosis After Proton Beam Therapy for Non-small Cell Lung Cancer2012

    • Author(s)
      Nagano T, et al.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42 Issue: 10 Pages: 965-969

    • DOI

      10.1093/jjco/hys115

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 粒子線がん治療の現状と将来 -急速に普及も患者の高額負担が課題-2012

    • Author(s)
      村上昌雄
    • Journal Title

      エネルギーレビュー

      Volume: 32 Pages: 15-18

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 粒子線治療に伴う難治性皮膚潰瘍の検討2012

    • Author(s)
      芝岡美枝,  他
    • Journal Title

      形成外科

      Volume: 55 Pages: 527-537

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ゲムシタビン併用陽子線治療を行い3年以上の生存が得られている局所進行切除不能膵癌の1例2012

    • Author(s)
      松本逸平,  他
    • Journal Title

      膵・胆道癌FRONTIER

      Volume: 2 Pages: 46-47

    • Related Report
      2012 Annual Research Report
  • [Journal Article] CRABP1-reduced expression is associated with poorer prognosis in serous and clear cell ovarian adenocarcinoma2012

    • Author(s)
      Miyake T, Ueda Y, Matsuzaki S, Miyatake T, Yoshino K, Fujita M, Nomura T, Enomoto T,Kimura T
    • Journal Title

      Cancer Res Clin Oncol

      Volume: 137 Issue: 4 Pages: 715-722

    • DOI

      10.1007/s00432-010-0930-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrating Complimentary and Alternative Medicinein Formof Active Hexose Co-Related Compound (AHCC) in the Management of Head & Neck Cancer Patient2012

    • Author(s)
      D.K.Parida, et al
    • Journal Title

      Int.J.Clinical Medicine

      Volume: 2 Issue: 05 Pages: 588-592

    • DOI

      10.4236/ijcm.2011.25097

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 宇宙環境の人体影響評価と防護に関する研究;放射線晩発影響の防護2012

    • Author(s)
      野村大成, 他
    • Journal Title

      Space Util.Res.

      Volume: 28(3月、印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of novel glycolipid antigens with an β-galactose epitope in lactobacilli detected with rabbit anti-Lactobacillus antisera and occurrence of antibodies against them in human sera2011

    • Author(s)
      Masao Iwamori, et al
    • Journal Title

      J.Biochem.

      Volume: 150 Issue: 5 Pages: 515-523

    • DOI

      10.1093/jb/mvr091

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus2011

    • Author(s)
      Komatsu S., et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 46(7) Issue: 7 Pages: 913-920

    • DOI

      10.1007/s00535-011-0398-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for survival and local recurrence after particle radiotherapy for single small hepatocellular carcinoma2011

    • Author(s)
      Komatsu S., et al
    • Journal Title

      Br.J.Surg.

      Volume: 98(4) Issue: 4 Pages: 558-564

    • DOI

      10.1002/bjs.7397

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma2011

    • Author(s)
      Komatsu S., et al
    • Journal Title

      Cancer

      Volume: 117(21) Issue: 21 Pages: 4890-4904

    • DOI

      10.1002/cncr.26134

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-institutional Phase II study of proton beam therapy for organ-confined prostate cancer focusing on the incidence of laterectal toxicities2011

    • Author(s)
      Nihei K., et al
    • Journal Title

      Int.J.Radiat.Oncol.Biol.Phys.

      Volume: 81 Issue: 2 Pages: 390-396

    • DOI

      10.1016/j.ijrobp.2010.05.027

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka2011

    • Author(s)
      Masuyama H, Yamada M, Kamei Y, Fujiwara-Ishikawa T, Todo T, Nagahama Y, Matsuda M
    • Journal Title

      Chromosome Res

      Volume: 20(1) Issue: 1 Pages: 163-76

    • DOI

      10.1007/s10577-011-9264-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase2011

    • Author(s)
      Zhang Y, et al
    • Journal Title

      Biochemistry

      Volume: 50 Issue: 18 Pages: 3591-3598

    • DOI

      10.1021/bi1019397

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and easy method forthe qualitative detection of intracellular deposition of inhaled nanoparticles2011

    • Author(s)
      Nakajima H, Ozaki K, Hongyo T, Narama I, Todo T
    • Journal Title

      Nanomedicine

      Volume: 7 Issue: 6 Pages: 881-888

    • DOI

      10.1016/j.nano.2011.02.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Establishment of Prostate Cancer and Benign Prostatic Hyperplasia PDX (Patient-Derived Xenograft) in Super-SCID Mice2015

    • Author(s)
      Taisei Nomura
    • Organizer
      International Conference on Prostate Cancer
    • Place of Presentation
      Hyatt Regency, Orlando, Florida, USA
    • Year and Date
      2015-06-22 – 2015-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of mutagenesis in Medaka fish2015

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Eri Shiraishi, Takeshi Todo.
    • Organizer
      International Symposium on Genome Science 2015
    • Place of Presentation
      一橋講堂、東京
    • Year and Date
      2015-01-20 – 2015-01-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transgenerational Health Effects of Radiation in Mice and Humans.2014

    • Author(s)
      Nomura, T.
    • Organizer
      XIII Annual Congress “New Technologies in Pediatria and Children’s Surgery” Symposium on "Mechanism of Radiation-induced Health State in the Next Generations after radiation exposure"
    • Place of Presentation
      Hotel "Cosmos", Moscow, Russia
    • Year and Date
      2014-10-21 – 2014-10-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] TALENs によるメダカにおける TLS ポリメラーゼ遺伝子群変異体の網羅的作製2014

    • Author(s)
      藤川 芳宏、藤原(石川)智子、佐久間哲史、山本 卓、藤堂 剛
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター、鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] CRISPR/Cas9システムによるメダカ光回復酵素遺伝子変異体の樹立2014

    • Author(s)
      藤原(石川) 智子、藤川芳宏、藤堂 剛
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター、鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] メダカ生殖細胞における放射線誘発遺伝的不安定性の解析2014

    • Author(s)
      藤原(石川) 智子、音在信治、尾田正二、三谷啓志、猪原秀典、藤堂 剛
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター、鹿児島市
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional conversion of (6-4) photolyase and CPD photolyase2014

    • Author(s)
      Daichi Yamada, Junpei Yamamoto, Tomoko Ishikawa, Tomohiro Suzuki, I M. Mahaputra Wijaya, Tatsuya Iwata, Elizabeth D. Getzoff, Takeshi Todo, Shigenori Iwai and Hideki Kandori.
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 変異導入による(6-4)光回復酵素からCPD光回復酵素への機能転換2014

    • Author(s)
      山田 大智、山元淳平、I. M. Mahaputra Wijaya、岩田達也、鈴木智大、石川智子、Elizabeth D. Getzoff、藤堂 剛、岩井 成憲、神取 秀樹
    • Organizer
      第24回日本光生物学協会年会
    • Place of Presentation
      大阪市立大学学術情報総合センター、大阪市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム編集技術:CRISPR/Cas9システムによるメダカ光回復酵素遺伝子変異体の樹立2014

    • Author(s)
      藤原(石川) 智子、藤川芳宏、藤堂 剛
    • Organizer
      第24回日本光生物学協会年会
    • Place of Presentation
      大阪市立大学学術情報総合センター、大阪市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] TALENsを利用した遺伝子破壊によるメダカの損傷乗り越えDNA合成ポリメラーゼ遺伝子変異体の作成2014

    • Author(s)
      藤川 芳宏、藤原(石川)智子、佐久間哲史、山本 卓、藤堂 剛
    • Organizer
      第24回日本光生物学協会年会
    • Place of Presentation
      大阪市立大学学術情報総合センター、大阪市
    • Year and Date
      2014-08-22 – 2014-08-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Suppression of Mouse and Human Cancer by AHCC.2014

    • Author(s)
      Taisei Nomura, Shigeki Adachi, Haruko Ryo, Eiko Hatanaka, Momoyo Kaji, Koujun Yasuda.
    • Organizer
      22nd ICNIM 2014
    • Place of Presentation
      Hotel Royton Sapporo, Sapporo
    • Year and Date
      2014-07-27 – 2014-07-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CRISPR/Cas9システムによるメダカ光回復酵素遺伝子変異体の樹立2014

    • Author(s)
      藤原(石川) 智子、藤川芳宏、 藤堂 剛
    • Organizer
      第36回光医学光生物学会
    • Place of Presentation
      大阪大学医学部学友会館、吹田市、大阪
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射線照射後の体細胞アポトーシス誘発および細胞周期停止におよぼす2014

    • Author(s)
      杉本奈央、桑原由樹、尾崎依里奈、藤川和男
    • Organizer
      第38回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      近畿大学11月ホール、東大阪市
    • Year and Date
      2014-06-26 – 2014-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳酸菌の腸内共生と免疫の役割2014

    • Author(s)
      岩森正男、足立成基、野村大成、田中京子、青木大輔
    • Organizer
      第56回日本脂質生化学会「ライフサイエンスにおける脂質生化学研究」
    • Place of Presentation
      近畿大学東大阪キャンパス、東大阪市
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「放射線毒性学における課題」、放射線及び化学物質の継世代影響2013

    • Author(s)
      野村大成
    • Organizer
      第40回日本毒性学会学術年会シンポジウム
    • Place of Presentation
      幕張メッセ国際会議場、千葉市、千葉県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Inhibitory effects of Tadalafil on prostate cell growth; a study using human benign prostatic hyperplasia xenografts in super-SCID mice2013

    • Author(s)
      Hiroshi Kiuchi, et al.
    • Organizer
      14th Asian Pacific Society for Sexual Medicine
    • Place of Presentation
      Ishikawa Ingakudo、Kanazawa、石川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of AHCC on Tumor Growth and Development2013

    • Author(s)
      T. Nomura, et al.
    • Organizer
      21st ICNIM
    • Place of Presentation
      ホテルロイトン、札幌市、北海道
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Inhibitory effects of Tadalafil on prostate cell growth; a study using a novel human benign prostatic hyperplasia xenografts in super-SCID mice2013

    • Author(s)
      Hiroshi Kiuchi, et al.
    • Organizer
      43rd ICS 2013
    • Place of Presentation
      CCIB Centre Convencions International de Barcerona, Barcerona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Direct effects of radiation and chemicals on human2013

    • Author(s)
      Nomura T.
    • Organizer
      11th Int. Conference on Environmental Mutagens
    • Place of Presentation
      国際会議場、Cataratas do Iguassu, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Transgenerational Health Effects of Radiation in Mice and Humans2013

    • Author(s)
      Taisei Nomura
    • Organizer
      XII Inovation Technologies in Pediatrics and Children's Surgery, Symposium “the Health State of 1st and 2nd offspring of Radiaton . Exposed Peson”
    • Place of Presentation
      コスモスホテル、Moscow, Russia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Targeted Inactivation of DNA photolyase family genes using CRISPR system2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, et al.
    • Organizer
      The 6th Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Novotel Sydney Central, Sydney, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DNA-photolyase and Cryptochrome2013

    • Author(s)
      Takeshi Todo
    • Organizer
      The 1st Awaji International Workshop on Electron Spin Science & Technology
    • Place of Presentation
      淡路夢舞台国際会議場、淡路市、兵庫県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Atm遺伝子ヘテロマウスの放射線応答に関する研究2013

    • Author(s)
      杉本奈央、他
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      江陽グランドホテル、仙台市、宮城県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線に対する胎児マウスの突然変異応答2013

    • Author(s)
      川﨑祐也、他
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      江陽グランドホテル、仙台市、宮城県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線に対する胎児と成体マウスの突然変異応答の比較2013

    • Author(s)
      尾崎依里奈、他
    • Organizer
      日本環境変異原学会第42回大会
    • Place of Presentation
      岡山コンベンションセンター、岡山市、岡山県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 宇宙環境の人体影響評価と防護に関する研究2013

    • Author(s)
      野村大成
    • Organizer
      第28回宇宙利用シンポジュウム
    • Place of Presentation
      日本学術会議、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 核分裂中性子に対するマウス胎児体細胞の突然変異応答2013

    • Author(s)
      川﨑祐也, 他
    • Organizer
      日本原子力学会2013年春の年会
    • Place of Presentation
      近畿大学東大阪キャンパス(東大阪市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prevention of Cancer and Radiation Induced Disorders by Active Hexose Correlated Compound, AHCC in Mice and Humans2012

    • Author(s)
      Taisei Nomura, et al.
    • Organizer
      20th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Hotel Royton Sapporo
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Direct effect of radiation on human tissues maintained in super SCID mice2012

    • Author(s)
      Taisei Nomura
    • Organizer
      2012 International Conference on Radiation Biology
    • Place of Presentation
      ACTREC, Tata Memorial Centre, Navi Mumbai, India
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] デュタステリドのヒト前立腺への影響-スーパーSCIDマウスへの移植モデルを用いた組織学検討2012

    • Author(s)
      辻村 晃、 他
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「放射線規制値の科学的根拠」とくに線量率軽減係数について2012

    • Author(s)
      野村大成
    • Organizer
      第 55回日本放射線影響学会特別シンポジウム
    • Place of Presentation
      東北大学, 仙台
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 消化管、皮膚および口腔共生細菌脂質の特異的分子種構成と糖脂質の抗原性2012

    • Author(s)
      岩森正男、 他
    • Organizer
      第54回日本脂質生化学会講演要旨集42-45
    • Place of Presentation
      九州大学医学部百年講堂、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 免疫不全マウス消化管におけるフコシルGA1の発現増加 Enhanced expression of fucosyl GA1 in the digestive tract of immune-deficient mice2012

    • Author(s)
      岩森正男、 他
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場 マリンメッセ福岡、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線被ばくの不安に対するカウンセリングツールの開発2012

    • Author(s)
      大石祥子、 他
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 速中性子およびX線照射を受けたメダカの腎臓細胞における小核誘発に関する研究2012

    • Author(s)
      高井明徳、 他
    • Organizer
      日本環境変異原学会第41回大会
    • Place of Presentation
      グランシップ(静岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Efficacy and safety of particle radiotherapy as a first treatment for fresh cases of hepatocellular carcinoma2011

    • Author(s)
      Terashima K., et al
    • Organizer
      International Liver Cancer Assosiation
    • Place of Presentation
      香港
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Particle radiotherapy for patients with metastatic bone tumor2011

    • Author(s)
      Murakami M., et al
    • Organizer
      The 44th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      京都
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Particle Therapy for Histologically Unproven Lung Nodules Highly Suggestive of Stage I Lung Cancer on Radiologic Examination2011

    • Author(s)
      Fujii O., et al
    • Organizer
      14th WCLC
    • Place of Presentation
      オランダ
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 放射線の遺伝的影響と胎児影響2011

    • Author(s)
      藤川和男
    • Organizer
      第37回臨床細胞分子遺伝研究会
    • Place of Presentation
      兵庫医科大学
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proton vs.Carbon ; Clinical experiences at the Hyogo Ion Beam Medical Center (HIBMC)2011

    • Author(s)
      Murakami M., et al
    • Organizer
      50th PTCOG
    • Place of Presentation
      Philadelphia USA
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibition of Radiation Induced Late Effects (Congenital Malformations and Leukemia) by Active Hexose Correlated Compound, AHCC in Mice2011

    • Author(s)
      Taisei Nomura, et al
    • Organizer
      19th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fukushima Nuclear Plants Accident : Radiation Effects on Human Health, "Philosophy on Safety and Conscience" in Japan2011

    • Author(s)
      Taisei Nomura
    • Organizer
      19th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] <環境ホルモンから見た放射能汚染> 放射線と化学物質複合曝露

    • Author(s)
      野村大成
    • Organizer
      第26回環境ホルモン学会講演会
    • Place of Presentation
      東京大学山上会館、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 放射線の次世代への影響

    • Author(s)
      野村大成
    • Organizer
      原爆2世問題専門家講演会
    • Place of Presentation
      韓国陜川(ハプチョン赤十字会館、陜川、韓国
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 放射線の継世代影響とは

    • Author(s)
      野村大成
    • Organizer
      シンポジュウム「放射線影響の真実に迫る」
    • Place of Presentation
      東京しごとセンター、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ゴカイ Platynereis dumerii 由来Cryptochrome-DASHにおける2つの発色団の結合特性

    • Author(s)
      直原 一徳、 他
    • Organizer
      第17回日本光生物学協会年会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 人工ヌクレアーゼを利用した遺伝子改変によるメダカの損傷応答遺伝子変異体の作製

    • Author(s)
      藤川 芳宏、 他
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] メダカTILLINGライブラリーにおける変異体の網羅的スクリーニング

    • Author(s)
      藤原(石川)智子、 他
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 体細胞モザイク作成により体組織レベルでの遺伝子機能解析計確立

    • Author(s)
      藤堂 剛、 他
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] High throughput screening of induced mutations in Medaka TILLING library by Next Generation Sequencer

    • Author(s)
      Tomoko Ishikawa-Fujiawara, et al.
    • Organizer
      18th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] ATF6 plays an essential role in induction of ER chaperones required for notochord formation

    • Author(s)
      Tokiro Ishikawa, et al.
    • Organizer
      18th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] BBF2H7 is required for the correct formation of vertebral bodies and cartilage in medaka

    • Author(s)
      Takuya Toyama, et al.
    • Organizer
      18th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Annual Research Report
  • [Presentation] 人工ヌクレアーゼによるゼブラフィッシュ培養細胞の遺伝子変異細胞の作製

    • Author(s)
      藤川 芳宏、 他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 体幹部定位放射線治療の現状と未来 4.体幹部領域における粒子線治療

    • Author(s)
      村上昌雄
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 荷電粒子線治療の現況と将来展望 (前編:総論、頭頸部腫瘍、肺癌、食道癌)

    • Author(s)
      村上昌雄
    • Organizer
      STR Medical Conference
    • Place of Presentation
      郡山市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 荷電粒子線治療の現況と将来展望 後編:肝胆膵領域腫瘍、前立腺癌、骨軟部腫瘍、その他の疾患、粒子線治療の問題点・課題・展望)

    • Author(s)
      村上昌雄
    • Organizer
      STR Medical Conference
    • Place of Presentation
      郡山市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 粒子線(陽子線・炭素イオン線)治療について

    • Author(s)
      村上昌雄
    • Organizer
      第7回PET・核医学看護研究会セミナー
    • Place of Presentation
      大阪市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Particle radiotherapy for patient with hepatocellular carcinoma

    • Author(s)
      Murakami M
    • Organizer
      CAARI2012
    • Place of Presentation
      フォートワース 米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] Borderline resectable膵癌の治療方針

    • Author(s)
      村上昌雄
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 粒子線治療の現状と皮膚科領域における取り組み

    • Author(s)
      村上昌雄
    • Organizer
      第64回日本皮膚学会西部支部学術大会
    • Place of Presentation
      広島市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 同じ線量分割で照射した陽子線と炭素イオン線治療の治療成績の比較

    • Author(s)
      村上昌雄, 他
    • Organizer
      日本放射線腫瘍学会第25回学術大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 体幹部腫瘍に対する粒子線(陽子線・炭素イオン線)治療

    • Author(s)
      村上昌雄
    • Organizer
      NPO日中協力機構医療技術シンポジウム
    • Place of Presentation
      中国 北京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 粒子線単独治療の時代から粒子線を含む集学的治療法への変容

    • Author(s)
      村上昌雄
    • Organizer
      平成24年度 第3回(通算第406回)放射線治療談話会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] がんの予防シリーズ④ [人の放射線発がんの予防]2013

    • Author(s)
      野村大成
    • Total Pages
      20
    • Publisher
      安田記念医学財団
    • Related Report
      2013 Annual Research Report
  • [Book] がんの予防シリーズ④ [人の放射線発がんの予防]2013

    • Author(s)
      野村大成
    • Total Pages
      20
    • Publisher
      安田記念医学財団
    • Related Report
      2012 Annual Research Report
  • [Book] 「3.11と私」2012

    • Author(s)
      野村大成
    • Total Pages
      5
    • Publisher
      藤原書店
    • Related Report
      2012 Annual Research Report
  • [Book] 放射線医学 放射線腫瘍学、粒子線治療(陽子線,炭素線)2012

    • Author(s)
      村上昌雄
    • Total Pages
      11
    • Publisher
      金芳堂
    • Related Report
      2012 Annual Research Report
  • [Book] 臨床放射線腫瘍学 最新知見に基づいた放射線治療の実践、肝細胞がん2012

    • Author(s)
      寺嶋千貴, 他
    • Total Pages
      16
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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