Investigation of the behavior of biomolecules in the controlled carbon nanospace and application for the bio-nanomaterials
Project/Area Number |
23241039
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Nanomaterials/Nanobioscience
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Research Institution | Tohoku University |
Principal Investigator |
KYOTANI Takashi 東北大学, 多元物質科学研究所, 教授 (90153238)
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Co-Investigator(Kenkyū-buntansha) |
HOSHIKAWA Yasuto 東北大学, 多元物質科学研究所, 助教 (90527839)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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Keywords | ナノ材料 / ナノチューブ・フラーレン / ナノバイオ / 炭素 / 薬物輸送 / 酵素電極 / ナノカーボン / ナノ空間 / DNA / バイオマテリアル |
Outline of Final Research Achievements |
The unique behavior of the biomolecules in the carbon nanospace was investigated, and the application for the bio-nanomaterials was attempted. Carbon nano-test-tubes (CNTTs) were obtained from the carbon-coated aluminum anodic oxidized (CAAO) film which has uniform and tubular nanochannels by the removal of the alumina template. Nucleotide molecules were highly concentrated into the inner nanospace of the CNTTs, and the nucleotide could be released. The observed properties are useful as a nanostorage medium for application of the gene delivery. Fibrillation of the amyloid β peptides (Aβ) which is a cause of Alzheimer disease was inhibited by adding the CNTTs. Redox enzymes immobilized into the carbon nanospace of the CAAO film react with fructose or oxygen and the electrons were directly transported in the CAAO nanochannels. It could be used as an enzymatic electrode. We indeed confirmed that a bio-fuel cell fabricated from the electrodes can work very well.
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Report
(5 results)
Research Products
(43 results)
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[Presentation] 精製ラッカーゼを担持した炭素被覆アルミニウム陽極酸化皮膜による酵素電極の作製と評価2014
Author(s)
多和田華子, Alberto Castro-Muniz, 込山 拓, 中山 航, 干川康人, 京谷 隆, 山根祥平, 野崎功一, 天野良彦, 伊藤徹二
Organizer
第14回多元物質科学研究所研究発表会
Place of Presentation
日本,仙台
Year and Date
2014-12-05
Related Report
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[Presentation] 黒鉛及び高温処理炭素のエッジ面の分析に基づく構造解析とその応用2014
Author(s)
石井孝文, 柏原 進, 大谷尚史, 小林俊介, 干川康人, 西原洋知, 京谷 隆, 鏑木 裕, 吉田明, 菱山幸宥, 神成尚克, 尾崎純一, 高井和之, 榎 敏明, 岡 秀亮
Organizer
平成26年度化学系学協会東北大会
Place of Presentation
日本,米沢
Year and Date
2014-09-20 – 2014-09-21
Related Report
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[Presentation] 温処理炭素のエッジ面の分析とそれによる炭素構造の解析2014
Author(s)
石井孝文, 柏原 進, 大谷尚史, 小林俊介, 干川康人, 西原洋知, 京谷 隆, 鏑木 裕, 吉田 明, 菱山幸宥, 神成尚克, 尾崎純一, 高井和之, 榎敏明
Organizer
第52回炭素材料夏季セミナー
Place of Presentation
日本,仙台
Year and Date
2014-08-25 – 2014-08-26
Related Report
Invited
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