Research on neural basis for deliberate decision

• Project/Area Number: 23243077
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: Tamagawa University
• Principal Investigator: SAKAGAMI Masamichi 玉川大学, 脳科学研究所, 教授 (10225782)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Tetsuya 玉川大学, 脳科学研究所, 准教授 (30384720)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000); Fiscal Year 2013: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2012: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2011: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
• Keywords: ドーパミンニューロン / 認知的不協和 / モデルベースvs.モデルフリー / コスト-ベネフィット / 意思決定 / 前頭前野 / モデルベース / 思考 / 目標指向性

Research Abstract

Have made research on inference function in monkey brains by using our originally developed inference tasks (Pan et al., 2008) for study of basic process of thinking. As the result, 1) in single unit recording, neurons in lateral prefrontal cortex showed activity of transitive inference function, while basal ganglia (striatum) showed no such activities, 2) it was suggested that transitive inference function in lateral prefrontal cortex was closely related to categorical process (Pan & Sakagami, 2012), and 3) it was found by local field potential analysis with simultaneous multi-electrode recording that information transmission from the lateral prefrontal cortex to the striatum played an important role in performing the task appropriately.

Research Products

• [Journal Article] Reward inference by primate prefrontal and striatal neurons (2014)
  • Author(s): Pan X, Fan H, Sawa K, Tsuda I, Tsukada M, Sakagami M
  • Journal Title: J. Neurosci Volume: 34 Pages: 1380-1396
  • Peer Reviewed
• [Journal Article] 前頭前野におけるカテゴリー形成 (2014)
  • Author(s): 小口峰樹、田中慎吾、Xiaochuan Pan、坂上雅道
  • Journal Title: 月刊 臨床神経科学 Volume: 32 Pages: 62-66
• [Journal Article] Reward inference by primate prefrontal and striatal neurons (2014)
  • Author(s): Pan X, Fan H, Sawa K, Tsuda I, Tsukada M, Sakagami M
  • Journal Title: The Journal of neuroscience: the official journal of the Society for Neuroscience Volume: 34 Pages: 1380-1396
  • Peer Reviewed
• [Journal Article] 前頭前野におけるカテゴリー形成 (2014)
  • Author(s): 小口 峰樹、田中 慎吾、Xiaochuan Pan、坂上 雅道
  • Journal Title: 月刊 臨床神経科学 Volume: 32 Pages: 62-66
• [Journal Article] Estimating causal interaction between prefrontal cortex and striatum by transfer entropy (2013)
  • Author(s): Ma C, Pan X, Wang R, Sakagami M
  • Journal Title: Cognitive neurodynamics Volume: 7 Pages: 253-261
  • Peer Reviewed
• [Journal Article] Reward prediction error signal enhanced by striatum-amygdala interaction explains the acceleration of probabilistic reward learning by emotion (2013)
  • Author(s): Watanabe N, Sakagami M, Haruno M
  • Journal Title: J. Neurosci Volume: 33 Pages: 4487-4493
  • Peer Reviewed
• [Journal Article] 予測と意思決定の神経科学 意思決定にかかわる二つの神経回路 (2013)
  • Author(s): 坂上雅道
  • Journal Title: 生体の科学 Volume: 64 Pages: 301-306
• [Journal Article] Changing the mind? Not really -- activity and connectivity in the caudate correlates with changes of choice (2013)
  • Author(s): Ito T, Wu DA, Marutani T, Yamamoto M, Suzuki H, Shimojo S, Matsuda T
  • Journal Title: Soc Cogn Affect Neurosci Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] リアルタイムfMRIによるニューロフィードバックの基礎とその応用 (2013)
  • Author(s): 土師知己、松田哲也
  • Journal Title: 精神科 Volume: 22 Pages: 375-381
• [Journal Article] Reward prediction error signal enhanced by striatum-amygdala interaction explains the acceleration of probabilistic reward learning by emotion (2013)
  • Author(s): Watanabe N, Sakagami M, Haruno M
  • Journal Title: The Journal of neuroscience: the official journal of the Society for Neuroscience Volume: 33 Pages: 4487-4493
  • Peer Reviewed
• [Journal Article] 予測と意思決定の神経科学 意思決定にかかわる二つの神経回路 (2013)
  • Author(s): 坂上 雅道
  • Journal Title: 生体の科学 Volume: 64 Pages: 301-306
• [Journal Article] Reward prediction error signal enhanced by striatum-amygdala interaction explains the acceleration of probabilistic reward learning by emotion (2013)
  • Author(s): Watanabe N.
  • Journal Title: J Neurosci. Volume: 33(10) Issue: 10 Pages: 4487-4493
  • DOI: 10.1523/jneurosci.3400-12.2013
  • Peer Reviewed
• [Journal Article] Category representation and generalization in the prefrontal cortex (2012)
  • Author(s): Pan X
  • Journal Title: Eur J Neurosci Volume: 35 Pages: 1083-1091
  • Peer Reviewed
• [Journal Article] Performance Dip in Motor Response Induced by Task-Irrelevant Weaker Coherent Visual Motion Signals (2012)
  • Author(s): Yotsumoto Y
  • Journal Title: Cereb Cortex Volume: 22 Pages: 1887-1893
  • Peer Reviewed
• [Journal Article] 線条体と前頭前野における価値の表象 (2012)
  • Author(s): 坂上雅道
  • Journal Title: Brain Nerve Volume: 64 Pages: 891-901
• [Journal Article] Neural circuits in the brain that are activated when mitigating criminalsentences (2012)
  • Author(s): Yamada M, Camerer CF, Fujie S, Kato M, Matsuda T, Takano H, Ito H, Suhara T, Takahashi H
  • Journal Title: Nature Communications Volume: 3 Pages: 759-759
  • Peer Reviewed
• [Journal Article] Category representation and generalization in the prefrontal cortex. (2012)
  • Author(s): Pan, X., & Sakagami, M.
  • Journal Title: European Journal of Neuroscience Volume: 35(7) Issue: 7 Pages: 1083-1091
  • DOI: 10.1111/j.1460-9568.2011.07981.x
  • Peer Reviewed
• [Journal Article] Stimulus-dependent adjustment of reward-prediction error in the midbrain (2011)
  • Author(s): Takemura H, Samejima K, Vogels R, Sakagami M & Okuda J
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Physical Intuitions about Support Relations in Monkeys (Macaca Fuscata) (2011)
  • Author(s): Murai C, Tanaka M & Sakagami M
  • Journal Title: Developmental Psychobiology Volume: 53 Pages: 732-737
  • Peer Reviewed
• [Journal Article] Combinational Fusion Analysis in Brain Informatics : Gender Variation in Facial Attractiveness Judgment (2011)
  • Author(s): Hsu DF, ItoT, Schweikert C, Matsuda T, Shimojo S
  • Journal Title: Brain Informatics Lecture Note in Computer Science Pages: 2-20
  • Peer Reviewed
• [Journal Article] Performance Dip in Motor Response Induced by Task-Irrelevant Weaker Coherent Visual Motion Signals (2011)
  • Author(s): Yotsumoto, Y.
  • Journal Title: Cereb Cortex Volume: 22(8) Issue: 8 Pages: 1887-1893
  • DOI: 10.1093/cercor/bhr270
  • Peer Reviewed
• [Journal Article] Stimulus-dependent adjustment of reward prediction error in the midbrain (2011)
  • Author(s): Takemura, H., Samejima, K., Vogels, R., Sakagami, M., Okuda, J.
  • Journal Title: PLoS ONE Volume: 6(12) Issue: 12 Pages: e28337-e28337
  • DOI: 10.1371/journal.pone.0028337
  • Peer Reviewed
• [Journal Article] Physical Intuitions about Support Relations in Monkeys (Macaca fuscata) and Apes (Pan troglodytes) (2011)
  • Author(s): Murai, C.
  • Journal Title: Journal of Comparative Psychology Volume: 125(2) Issue: 2 Pages: 216-226
  • DOI: 10.1037/a0022099
  • Peer Reviewed
• [Journal Article] Long-term visual recognition of familiar persons, peers, and places by young monkeys (Macaca fuscata) (2011)
  • Author(s): Murai, C., Tanaka, M., Tomonaga, M., Sakagami, M.
  • Journal Title: Developmental Psychobiology online Volume: 53 Issue: 7 Pages: 732-737
  • DOI: 10.1002/dev.20548
  • Peer Reviewed
• [Presentation] The Enhancement of the reward value by the cost paid for the reward (2014)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: Symposium on Human Cognitive Neuroscience : Neural Dynamics of Internal Switching
  • Place of Presentation: 九州大学(福岡県福岡市)
  • Year and Date: 2014-01-23
• [Presentation] Reward inference by prefrontal and striatal neurons (2014)
  • Author(s): 坂上雅道
  • Organizer: Symposium on Human Cognitive Neuroscience : Neural Dynamics of Internal Switching
  • Place of Presentation: 九州大学(福岡県福岡市)
  • Year and Date: 2014-01-23
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward (2014)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学(鹿児島県鹿児島市)
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward（ポスター発表） (2014)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: 第９１回日本生理学会大会
  • Place of Presentation: 鹿児島大学（鹿児島県鹿児島市）
• [Presentation] 幸せの相対性理論 (2014)
  • Author(s): 坂上 雅道
  • Organizer: シンポジウム「論理と感性の新たな学際研究に向けて」
  • Place of Presentation: 慶應義塾大学論理と感性のグローバルリサーチセンター（東京都港区）
  • Invited
• [Presentation] Reward inference by prefrontal and striatal neurons (2014)
  • Author(s): Masamichi Sakagami
  • Organizer: Symposium on Human Cognitive Neuroscience:Neural Dynamics of Internal Switching
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Invited
• [Presentation] The enhancement of the reward value by the cost paid for the reward (2014)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: Symposium on Human Cognitive Neuroscience:Neural Dynamics of Internal Switching
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Invited
• [Presentation] The effect of cost on the reward prediction error signal in the midbrain dopamine neuron (2013)
  • Author(s): Masamichi Sakagami
  • Organizer: Reward and Decision-making on Risk and Aversion
  • Place of Presentation: Hawaii(USA)
  • Year and Date: 2013-03-07
• [Presentation] Reward inference by prefrontal and striatal neurons in primate (2013)
  • Author(s): Masamichi Sakagami
  • Organizer: 人間とどうぶつの「意思決定・論理・認知」を探る-神経科学から哲学まで-国際・学際シンポジウムDecision Making, Logic and Cognition
  • Place of Presentation: 慶應義塾大学(東京都)
  • Year and Date: 2013-02-27
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward (2013)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: Society for Neuroscience 43^<rd> Annual Meeting 2013
  • Place of Presentation: San Diego Convention Center (USA)
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward (2013)
  • Author(s): Masamichi Sakagami
  • Organizer: Mini-Symposium on Neural Mechaisms of Value and Decision-Making
  • Place of Presentation: Caltech (USA)
• [Presentation] Monkey lateral prefrontal cortical neurons represent functional category of visual stimuli (2013)
  • Author(s): Hongwei Fan, Xiaochuan Pan, M. Sakagami
  • Organizer: Int'l symposium on Prediction and Decision Making
  • Place of Presentation: 京都大学(京都府京都市)
• [Presentation] The effect of cost on the reward preciction error signal in midbrain dopamine neurons (2013)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
• [Presentation] 科学技術の将来ビジョンについて (2013)
  • Author(s): 松田哲也
  • Organizer: 第90回日本生理学会大会学術・研究委員会企画フォーラム
  • Place of Presentation: 東京
• [Presentation] 幸せの相対性理論―ドーパミンニューロンと価値の相対化― (2013)
  • Author(s): 坂上 雅道
  • Organizer: さきがけ「脳情報の解読と制御」第１１回領域会議
  • Place of Presentation: ホテルピアノ（北海道余市郡）
  • Invited
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward（ポスター発表） (2013)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: Society for Neuroscience 43rd Annual Meeting 2013
  • Place of Presentation: San Diego Convention center (San Diego, CA, USA)
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward (2013)
  • Author(s): Masamichi Sakagami
  • Organizer: Mini-Symposium on Neural Mechanisms of Value and Decision-Making
  • Place of Presentation: Caltech (Los Angeles, CA, USA)
  • Invited
• [Presentation] Monkey lateral prefrontal cortical neurons represent functional category of visual stimuli (poster) (2013)
  • Author(s): Hongwei Fan, Xiaochuan Pan, M. Sakagami
  • Organizer: International symposium on Prediction and Decision Making
  • Place of Presentation: 京都大学（京都府京都市）
• [Presentation] The enhancement of the reward prediction error signal in the midbrain dopamine neuron by the cost paid for the reward (2013)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: International symposium on Prediction and Decision Making
  • Place of Presentation: 京都大学（京都府京都市）
• [Presentation] Reward inference by primate prefrontal and striatal neurons (2013)
  • Author(s): 坂上 雅道
  • Organizer: International symposium on Prediction and Decision Making
  • Place of Presentation: 京都大学（京都府京都市）
  • Invited
• [Presentation] 意思決定に関わる２つの神経回路とその相互作用 (2013)
  • Author(s): 坂上 雅道
  • Organizer: 福島県立医科大学医学部附属生体物質伝達研究所
  • Place of Presentation: 福島県立医科大学（福島県福島市）
• [Presentation] The effect of cost on the reward prediction error signal in midbrain dopamine neurons (poster) (2013)
  • Author(s): Shingo Tanaka, John P O'Doherty and Masamichi Sakagami
  • Organizer: 第３６回日本神経科学大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
• [Presentation] Reward inference by Primate Prefrontal and Striatal Neurons (2012)
  • Author(s): Masamichi Sakagami
  • Organizer: Annual Conference on Neuroeconomics
  • Place of Presentation: Key Biscayne(USA)
  • Year and Date: 2012-09-29
• [Presentation] 予測と創造-モデルベース的意思決定プロセスの基礎- (2012)
  • Author(s): 坂上雅道
  • Organizer: 第76回日本心理学会大会
  • Place of Presentation: 専修大学(神奈川県)
  • Year and Date: 2012-09-13
• [Presentation] Reward inference by primate prefrontal and striatal neurons (2012)
  • Author(s): Masamichi Sakagami
  • Organizer: Dynamics Brain Forum
  • Place of Presentation: Carmona(Spain)
  • Year and Date: 2012-09-04
• [Presentation] 精神疾患における脳機能障害の定量化と脳活動の制御 (2012)
  • Author(s): 松田哲也
  • Organizer: 精神医学セミナー
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2012-06-07
• [Presentation] 意志決定の神経基盤の研究とその展開 (2012)
  • Author(s): 坂上雅道
  • Organizer: 北海道大学GCOE「心の社会性に関する教育研究拠点」総括シンポジウム:心はなぜ、どのように社会的か?-フロンティアとアジェンダ
  • Place of Presentation: 学術総合センター,東京都(招待講演)
  • Year and Date: 2012-03-17
• [Presentation] Multiple neural circuits in value-based decision-making (2012)
  • Author(s): 坂上雅道
  • Organizer: Gaze Bias Learning II-Linking neuroscience, computational modeling, and cognitive development
  • Place of Presentation: 玉川大学(東京都)
  • Year and Date: 2012-03-12
• [Presentation] Multiple neural circuits in value-based decision-making (2012)
  • Author(s): 坂上雅道
  • Organizer: Gaze Bias Learning II-Linking neuroscience, computational modeling, and cognitive development
  • Place of Presentation: 玉川大学,東京都
  • Year and Date: 2012-03-12
• [Presentation] The Shorthanded Brain - Functional connectivity across Anterior Putamen in Top-notch Expertise of Stenography- (2012)
  • Author(s): T. Ito, T. Matsuda, S. Shimojo
  • Organizer: Neuroscience 2012, SfN's 42nd Annual Meeting
  • Place of Presentation: New Orleans (USA)
• [Presentation] 社会的判断におけるモデルベースプロセスとモデルフリープロセス (2011)
  • Author(s): 坂上雅道
  • Organizer: 平成23年度生理研研究会社会神経科学研究会「今、社会神経科学研究に求められていること」
  • Place of Presentation: 岡崎コンファレンスセンター,愛知県
  • Year and Date: 2011-10-06
• [Presentation] The Shorthanded Brain ? Functional connectivity across Arterior Putamen in Top-notch Expertise of Stenography- (2011)
  • Author(s): T. Ito, T. Matsuda, S.Shimojo
  • Organizer: 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋
  • Year and Date: 2011-09-17
• [Presentation] 判断にかかわる2つの神経回路 (2011)
  • Author(s): 坂上雅道
  • Organizer: 日本心理学会第75回大会シンポジウム「心の先端研究の現在と未来」
  • Place of Presentation: 日本大学文理学部(東京都)
  • Year and Date: 2011-09-17
• [Presentation] 判断にかかわる2つの神経回路 (2011)
  • Author(s): 坂上雅道
  • Organizer: 日本心理学会第75回大会シンポジウム「心の先端研究の現在と未来」
  • Place of Presentation: 日本大学文理学部,東京都(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] Neural Basis of Changing Face Preference Decision by Gaze Manipulation (2011)
  • Author(s): Takehito Ito, Toshiyuki Marutani, Manami Yamamoto, Hidenori Suzuki, Shinsuke Shimojo, Tetsuya Matsuda
  • Organizer: Neuroscience 2011, SfN's 41st Annual Meeting
  • Place of Presentation: Washington D.C.(USA)
• [Presentation] Neural Basis of Changing Face Preference Decision by Gaze Manipulation (2011)
  • Author(s): Takehito Ito, Toshiyuki Marutani, Manami Yamamoto, Hidenori Suzuki, Shinsuke Shimojo, Tetsuya Matsuda
  • Organizer: HBM 2011, 17th Annual Meeting of the OrganizationonHuman Brain Mapping
  • Place of Presentation: Quebec City.(Canada)
• [Presentation] Reward inference by primate prefrontal and strial neurons
  • Author(s): Masamichi Sakagami
  • Organizer: Dynamic Brain Forum
  • Place of Presentation: Carmona,Spain
  • Invited
• [Presentation] 予測と創造－モデルベース的意思決定プロセスの基礎－
  • Author(s): 坂上雅道
  • Organizer: 第76回日本心理学会大会
  • Place of Presentation: 専修大学生田キャンパス,神奈川県
• [Presentation] Reward Inference by Primate Prefrontal and Striatal Neurons, Annual Conference on Neuroeconomics
  • Author(s): Masamichi Sakagami
  • Organizer: Decision Making and the Brain
  • Place of Presentation: Key Biscayne,Frolida, Miami,USA
  • Invited
• [Presentation] Reward inference by prefontal and striatal neurons in primate
  • Author(s): Masamichi Sakagami
  • Organizer: 人間と動物の「意思決定・論理・認知」を探る-神経科学から哲学まで-国際・学際シンポジウム Decision Making, Logic and Cognition
  • Place of Presentation: 慶應義塾大学 三田キャンパス,東京都
  • Invited
• [Presentation] The effect of cost on the reward prediction error signal in the midbrain dopamine neuron
  • Author(s): Masamichi Sakagami
  • Organizer: Reward and Decision-making on Risk and Aversion
  • Place of Presentation: Hawaii, USA
• [Book] 社会脳シリーズ5報酬を期待する脳ニューロエコノミクスの新展開 (2014)
  • Author(s): 苧阪直行(編)、坂上雅道(4章執筆)
  • Total Pages: 158
  • Publisher: 新曜社
• [Book] 社会脳シリーズ5 報酬を期待する脳 ニューロエコノミクスの新展開 (2014)
  • Author(s): 苧阪 直行（編）、坂上 雅道（４章執筆）
  • Total Pages: 158
  • Publisher: 新曜社
• [Book] 最新心理学事典 (2013)
  • Author(s): 藤永保(監修)、坂上雅道(部分執筆)
  • Total Pages: 870
  • Publisher: 平凡社 (部分執筆)
• [Book] 最新心理学事典 (2013)
  • Author(s): 藤永 保（監修）、坂上 雅道（部分執筆）
  • Total Pages: 870
  • Publisher: 平凡社
• [Book] APA心理学大辞典 APA Dictionary of Psychology (2013)
  • Author(s): G.R.ファンデンボス（監修）、坂上 雅道（部分訳）
  • Total Pages: 1041
  • Publisher: 培風館